Newer antiphospholipid antibodies predict adverse outcomes in patients with acute coronary syndrome.

Abstract:

:Antiphospholipid antibodies (aPLs) have been implicated in atherogenesis. We studied 344 patients with acute coronary syndromes; approximately 40% were aPL+ in 1 or more tests and 60% aPL-. In 215 patients, coronary artery disease (CAD) was angiographically documented, with 43.7% positive for aPL vs 34.9% of patients without CAD positive for aPLs. Anti-beta(2)-glycoprotein I (beta2GPI; 54%) and anti-oxidized low-density lipoprotein (oxLDL)/beta2GPI (48%) were most frequent, accounting for 87% of all aPL+ CAD cases. aPLs correlated with severity of CAD (P = .012). Adverse events occurred in 16.7% of patients with CAD, more frequently in patients who were aPL+ (P = .0006; relative risk, 2.9; 95% confidence interval, 1.5-5.6). Patients who were aPL+ with severe CAD had more adverse events than patients who were aPL- with severe CAD (P = .005) and aPL+ patients undergoing revascularization procedures (P = .001). Vascular events occurred in 21.7% of aPL+ patients compared with 7.1% of aPL- patients (P = .005). Anti-beta2GPI and anti-oxLDL/beta2GPI were associated with CAD severity and adverse outcomes.

journal_name

Am J Clin Pathol

authors

Greco TP,Conti-Kelly AM,Greco T Jr,Doyle R,Matsuura E,Anthony JR,Lopez LR

doi

10.1309/AJCP2FJUT2YZGITK

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

613-20

issue

4

eissn

0002-9173

issn

1943-7722

pii

132/4/613

journal_volume

132

pub_type

杂志文章
  • Blue nevus of the lymph node capsule. Report of a new case with review of the literature.

    abstract::This article describes the seventh known case of blue nevus of the lymph node capsule and reviews the previously reported cases. The migration arrest hypothesis as an explanation for the occurrence of this lesion is favored rather than the "benign metastasis" hypothesis. The importance of the recognition of this pheno...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.3.367

    authors: Lamovec J

    更新日期:1984-03-01 00:00:00

  • Direct comparison of two mechanized systems for identification of gram-negative bacilli. Autobac ID system versus the auto microbic system (with EBC plus).

    abstract::The Auto Microbic System (AMS) is an almost completely automated system, capable of identifying Enterobacteriaceae after 8 hours, and some glucose nonfermenters after 13 hours of incubation. The Autobac ID system is a mechanized, computer-assisted system capable of identifying Enterobacteriaceae and many nonfermentati...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.4.462

    authors: Barry AL,Gavan TL,Badal RE,Telenson MJ

    更新日期:1982-10-01 00:00:00

  • Detection of influenza A and B viruses with the Sofia analyzer: a novel, rapid immunofluorescence-based in vitro diagnostic device.

    abstract::This report describes the clinical evaluation of a novel fluorescent immunoassay (FIA), Sofia Influenza A+B FIA (Quidel, San Diego, CA), for the rapid detection and differentiation of influenza A and B viruses. A total of 2,047 subjects provided nasal swabs and nasopharyngeal swabs or aspirates. The overall sensitivit...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1309/AJCP7ZTLJCP3LLMA

    authors: Lewandrowski K,Tamerius J,Menegus M,Olivo PD,Lollar R,Lee-Lewandrowski E

    更新日期:2013-05-01 00:00:00

  • Basal cell (monomorphic) and minimally pleomorphic adenomas of the salivary glands. Distinction from the solid (anaplastic) type of adenoid cystic carcinoma in fine-needle aspiration.

    abstract::Cytologic features of the cell-stroma interface are useful in distinguishing between monomorphic adenomas of the basal cell type and adenoid cystic carcinoma. In basal cell adenomas, the collagenous stroma interdigitates with adjacent cells, whereas in adenoid cystic carcinoma, the two are separated by a sharp smooth ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/106.1.35

    authors: Stanley MW,Horwitz CA,Rollins SD,Powers CN,Bardales RH,Korourain S,Stern SJ

    更新日期:1996-07-01 00:00:00

  • Paraffin-resistant antigens detectable by antibodies L26 and polyclonal CD3 predict the B- or T-cell lineage of 95% of diffuse aggressive non-Hodgkin's lymphomas.

    abstract::The reactivity of eight preferential B-cell (L26, 4KB5, and KiB3) and T-cell (polyclonal CD3, Leu22, MT-1, UCHL-1, and OPD4) antibodies which detect paraffin-resistant antigens was examined by a three-step immunoperoxidase technique in 111 formalin-fixed, paraffin-embedded diffuse aggressive non-Hodgkin's lymphomas (N...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.3.284

    authors: Chadburn A,Knowles DM

    更新日期:1994-09-01 00:00:00

  • Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.

    abstract::Micropapillary lung adenocarcinoma (MPA) has been reported as an aggressive variant of adenocarcinoma, frequently manifesting at high stage with a poor prognosis. We analyzed the clinical and molecular profile of 15 primary MPAs for K-ras, EGFR, and BRAF mutations and performed fluorescence in situ hybridization for E...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPBS85VJEOBPDO

    authors: De Oliveira Duarte Achcar R,Nikiforova MN,Yousem SA

    更新日期:2009-05-01 00:00:00

  • Aberrations of chromosomes 9 and 17 in bilharzial bladder cancer as detected by fluorescence in situ hybridization.

    abstract::Fluorescence in situ hybridization (FISH), using repetitive alpha satellite probes to chromosomes 9 and 17, was performed on 27 paraffinembedded bladder specimens from 18 Egyptian patients affected with bilharzial carcinoma. Fluorescence in situ hybridization results in the carcinomas and benign mucosa of patients wit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.2.234

    authors: Ghaleb AH,Pizzolo JG,Melamed MR

    更新日期:1996-08-01 00:00:00

  • Hemolytic disease of the newborn due to anti-C and anti-G masquerading as anti-D.

    abstract::After several transfusions with D-negative blood, an O Rh-negative women was apparently sensitized to the C and D antigens. In her prenatal workup, it became evident that she had in fact not been sensitized to D but to G, which initially appeared as anti-D plus anti-C. This sensitization pattern is an unusual occurren...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.6.769

    authors: Yesus YW,Akhter JE

    更新日期:1985-12-01 00:00:00

  • Prevalence of non-A,non-B hepatitis/hepatitis C virus antibody in human immunoglobulins.

    abstract::Human intravenous immunoglobulins prepared by the cold ethanol fractionation technique of Cohn are considered safe with respect to infectivity. However, there have been several instances of transmission of both hepatitis B and non-A,non-B hepatitis viruses after administration of intravenous immunoglobulins. To determ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.1.108

    authors: Dodd LG,McBride JH,Gitnick GL,Howanitz PJ,Rodgerson DO

    更新日期:1992-01-01 00:00:00

  • MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors.

    abstract:OBJECTIVES:MDM2 gene amplification is associated with well-differentiated (WDL) and dedifferentiated liposarcomas (DDL). Using fluorescent in situ hybridization (FISH), we sought to characterize various patterns of MDM2 amplification among the morphologic spectrum of liposarcoma. METHODS:Forty-six cases of liposarcoma...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPLYU89XHSNHQO

    authors: Ware PL,Snow AN,Gvalani M,Pettenati MJ,Qasem SA

    更新日期:2014-03-01 00:00:00

  • Essential thrombocythemia with acquired von Willebrand's disease.

    abstract::Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.1.102

    authors: Raman BK,Sawdyk M,Saeed SM

    更新日期:1987-07-01 00:00:00

  • Atypical glandular cells of undetermined significance. Diagnostic accuracy and interobserver variability using select cytologic criteria.

    abstract::Histologic follow-up of patients with the Bethesda system cervical-vaginal diagnosis of atypical glandular cells of undetermined significance (AGUS), "favor endocervical origin", or "not otherwise specified" (NOS) shows a high percentage of clinically significant (neoplastic or preneoplastic) lesions. Using the criter...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/107.3.299

    authors: Raab SS,Snider TE,Potts SA,McDaniel HL,Robinson RA,Nelson DL,Sigman JD,Thomas PA

    更新日期:1997-03-01 00:00:00

  • Hematologic and iron-related measurements in rheumatoid arthritis.

    abstract::The hematologic status of 265 patients with rheumatoid arthritis was assessed. In the group as a whole, a mild depression in the hemoglobin concentration and mean cell volume (MCV) was associated with an increase in the red blood cell distribution width (RDW), erythrocyte sedimentation rate (ESR), and platelet count. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.2.196

    authors: Baynes RD,Bothwell TH,Bezwoda WR,Gear AJ,Atkinson P

    更新日期:1987-02-01 00:00:00

  • Spurious elevation of the electronically determined mean corpuscular volume and hematocrit caused by hyperglycemia.

    abstract::Following normalization of blood glucose levels, a marked change in the MCV and in the calculated hematocrit was observed in five patients with transient severe hyperglycemia. The addition of varied concentrations of glucose to blood samples from healthy volunteers and from patients with microcytic, macrocytic, and no...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.5.561

    authors: Holt JT,DeWandler MJ,Arvan DA

    更新日期:1982-05-01 00:00:00

  • Comparison of two methods of mechanical disaggregation of scirrhous breast adenocarcinomas for DNA flow cytometric analysis of whole cells.

    abstract::Mechanical release of single cell suspensions from solid tumors for DNA analysis by flow cytometry has been shown to be optimal for adenocarcinomas in general. In the breast, many adenocarcinomas are fibrotic or scirrhous, creating difficulty in separating the neoplastic cells from the stroma. The authors have conduct...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.1.8

    authors: Torres FX,Mackowiak PG,Brown RD,Linden MD,Zarbo RJ

    更新日期:1995-01-01 00:00:00

  • Acute lymphocytic leukemia manifesting as splenic rupture.

    abstract::Pathologic rupture of the spleen is a rare phenomenon in acute lymphocytic leukemia, and its mechanism is unknown. This complication has been seen almost exclusively in men, and at ages much older than those of the majority of patients who have this leukemia; these unusual features are also unexplained. A case of acut...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.1.118

    authors: Johnson CS,Rosen PJ,Sheehan WW

    更新日期:1979-07-01 00:00:00

  • Mucoid Pseudomonas in cystic fibrosis.

    abstract::Pseudomonas aeruginosa is a frequent and virulent pulmonary pathogen in patients with cystic fibrosis. If colonization is not prevented, P aeruginosa becomes permanently established and nearly always mutates into a mucoid strain. The alginate-containing matrix of the mucoid strain is thought to allow the formation of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/KJRPC7DD5TR9NTDM

    authors: Pritt B,O'Brien L,Winn W

    更新日期:2007-07-01 00:00:00

  • Mastocytosis: an unusual clonal disorder of bone marrow-derived hematopoietic progenitor cells.

    abstract::Mastocytosis, an unusual disorder of bone marrow-derived, clonally transformed hematopoietic progenitor cells, exhibits a broad spectrum of clinical and morphologic features ranging from a self-limiting benign disorder (ie, juvenile cutaneous mastocytosis) to highly aggressive neoplasms like mast cell leukemia. Princi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPPXHMN5CJOXHZ

    authors: Horny HP

    更新日期:2009-09-01 00:00:00

  • Identification of methicillin-resistant staphylococci by multiplex polymerase chain reaction assay.

    abstract::A multiplex polymerase chain reaction (PCR) assay using oligonucleotide primers to detect mecA and 16S ribosomal RNA gene was developed to aid in identification of methicillin-resistant staphylococci. Validation included 99 isolates of staphylococcus grouped into one of five categories: methicillin-susceptible coagula...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/107.3.368

    authors: Salisbury SM,Sabatini LM,Spiegel CA

    更新日期:1997-03-01 00:00:00

  • Serum percent-free PSA does not predict extraprostatic spread of prostate cancer.

    abstract::Percent-free prostate-specific antigen (proportion of free prostate-specific antigen [PSA] to total PSA) has been shown recently in studies on frozen serum samples to be more useful than total PSA alone in distinguishing prostate cancer from benign conditions of the prostate gland. The primary purpose of our study was...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/109.5.533

    authors: Henricks WH,England BG,Giacherio DA,Oesterling JE,Wojno KJ

    更新日期:1998-05-01 00:00:00

  • Influence of blood collection systems on the prothrombin time and international sensitivity index determined with human and rabbit thromboplastin reagents.

    abstract::Three brands of blood collection tubes were studied for their influence on the prothrombin time (PT) and international sensitivity index (ISI) for 5 commercial thromboplastin reagents. With all reagents, PTs were shorter in Vacutainer (Becton Dickinson Vacutainer Systems, Plymouth, England) samples than in S-Monovette...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/NW194EAMD4WMEHJD

    authors: van den Besselaar AM,Hoekstra MM,Witteveen E,Didden JH,van der Meer FJ

    更新日期:2007-05-01 00:00:00

  • Breast carcinoma simulating fibroadenoma or fibrocystic change by fine-needle aspiration. A study of 16 cases.

    abstract::The cytologic features of fine-needle aspiration specimens from 16 breast carcinomas that closely simulated benign lesions were analyzed and compared to smears from fibroadenomas and fibrocystic change. No combination of features was found that accurately separated all benign and malignant cases. Many nuclei with disc...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/98.2.155

    authors: Rogers LA,Lee KR

    更新日期:1992-08-01 00:00:00

  • Sinonasal malignant melanoma. A clinicopathologic and immunohistochemical study of 14 cases.

    abstract::The clinical, light microscopic, and immunohistochemical features of 14 sinonasal malignant melanomas were studied to show their diverse morphologic appearance and distinction from therapeutically more amenable neoplasms that occur in this region. The tumors arose in 6 men and 8 women (median age, 70 years). Eleven pa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/96.6.689

    authors: Franquemont DW,Mills SE

    更新日期:1991-12-01 00:00:00

  • Linking Statistics With Testing Policy to Manage COVID-19 in the Community.

    abstract:OBJECTIVES:To determine the public health surveillance severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing volume needed, both for acute infection and seroprevalence. METHODS:Required testing volumes were developed using standard statistical methods based on test analytical performance, disease preval...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa099

    authors: Hilborne LH,Wagner Z,Cabreros I,Brook RH

    更新日期:2020-07-07 00:00:00

  • Platelet aggregation induced by antilymphocyte serum. 2. Two modes of the aggregation mechanism.

    abstract::The ability to inhibit the release reaction was found to correlate well with the ability to inhibit aggregation in washed human platelets exposed to antilymphocyte serum (ALS). However, the primary mechanism that contributes to ALS-induced aggregation in unwashed platelets appeared to be different from that found in w...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.5.680

    authors: Wang TY,Hussey CV,Hause LL,Fobian JE

    更新日期:1976-05-01 00:00:00

  • Analysis of cyclin D1 expression by quantitative real-time reverse transcription-polymerase chain reaction in the diagnosis of mantle cell lymphoma.

    abstract::Mantle cell lymphoma (MCL) is characterized by typical morphologic features and the CD5+, CD23-immunophenotype. However, some morphologically typical MCLs are CD23+. A t(11;14)(q13;q32) translocation is frequently found in MCL, leading to overexpression of cyclin D1. We studied the expression of cyclin D1 in 50 small ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/R2BC-2H7T-7KB6-0YG8

    authors: Peghini PE,Fehr J

    更新日期:2002-02-01 00:00:00

  • A cytochemical and ultrastructural study of acute myelomonocytic leukemia exhibiting the pseudo-Chediak-Higashi anomaly of leukemia and "splinter-type" Auer rods.

    abstract::An unusual case of acute myelomonocytic leukemia (AMML) in an 81-year-old man is described. Ultrastructural examination revealed the presence of distinct Auer bodies, which commonly are found in acute promyelocytic leukemia (APL). The Auer bodies had a splinterlike appearance with a distinct tubular substructure. The ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.2.216

    authors: Payne CM,Harrow EJ

    更新日期:1983-08-01 00:00:00

  • MUC4 expression increases progressively in pancreatic intraepithelial neoplasia.

    abstract::Pancreatic adenocarcinoma is believed to develop from histologically identifiable intraductal lesions known as pancreatic intraepithelial neoplasias (PanINs) that undergo a series of architectural, cytologic, and genetic changes, a progression model similar to the adenoma-carcinoma sequence in the colon. The apomucin ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/7Y7N-M1WM-R0YK-M2VA

    authors: Swartz MJ,Batra SK,Varshney GC,Hollingsworth MA,Yeo CJ,Cameron JL,Wilentz RE,Hruban RH,Argani P

    更新日期:2002-05-01 00:00:00

  • A cost-effective algorithm for hereditary nonpolyposis colorectal cancer detection.

    abstract::Colorectal cancer with microsatellite instability (MSI) may occur sporadically or be inherited in cases of hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. However, there is no consensus as to which patients must be tested and how to test MSI. In this study, MSI was tested by immunohistochemical analysis an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/B0AF-DT52-ETMK-EJBE

    authors: Bouzourene H,Taminelli L,Chaubert P,Monnerat C,Seelentag W,Sandmeier D,Andrejevic S,Matter M,Bosman F,Benhattar J

    更新日期:2006-06-01 00:00:00

  • The determination of reference values for hematologic parameters using results obtained from patient populations.

    abstract::Reference values for hematologic parameters are determined using data from patient populations of a whole year. As a consequence, the authors are not dependent on a limited selected population and can determine reference values for all age and sex groups. It turns out that from the possible compilation technics the ga...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.2.182

    authors: Swaanenburg JC,Rutten WP,Holdrinet AC,van Strik R

    更新日期:1987-08-01 00:00:00