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The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

Abstract：

:Structures of intact receptors with single-pass transmembrane domains are essential to understand how extracellular and cytoplasmic domains regulate association and signaling through transmembrane domains. A chemical and computational method to determine structures of the membrane regions of such receptors on the cell surface is developed here and validated with glycophorin A. An integrin heterodimer structure reveals association over most of the lengths of the alpha and beta transmembrane domains and shows that the principles governing association of hetero and homo transmembrane dimers differ. A turn at the Gly of the juxtamembrane GFFKR motif caps the alpha TM helix and brings the two Phe of GFFKR into the alpha/beta interface. A juxtamembrane Lys residue in beta also has an important role in the interface. The structure shows how transmembrane association/dissociation regulates integrin signaling. A joint ectodomain and membrane structure shows that substantial flexibility between the extracellular and TM domains is compatible with TM signaling.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Zhu J,Luo BH,Barth P,Schonbrun J,Baker D,Springer TA

doi

10.1016/j.molcel.2009.02.022

subject

Has Abstract

pub_date

2009-04-24 00:00:00

pages

234-49

issue

2

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(09)00138-5

journal_volume

34

pub_type

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