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Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association.

Abstract：

:The response to endoplasmic reticulum (ER) stress relies on activation of unfolded protein response (UPR) sensors, and the outcome of the UPR depends on the duration and strength of signal. Here, we demonstrate a mechanism that attenuates the activity of the UPR sensor inositol-requiring enzyme 1α (IRE1α). A resident ER protein disulfide isomerase, PDIA6, limits the duration of IRE1α activity by direct binding to cysteine 148 in the lumenal domain of the sensor, which is oxidized when IRE1 is activated. PDIA6-deficient cells hyperrespond to ER stress with sustained autophosphorylation of IRE1α and splicing of XBP1 mRNA, resulting in exaggerated upregulation of UPR target genes and increased apoptosis. In vivo, PDIA6-deficient C. elegans exhibits constitutive UPR and fails to complete larval development, a program that normally requires the UPR. Thus, PDIA6 activity provides a mechanism that limits UPR signaling and maintains it within a physiologically appropriate range.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Eletto D,Eletto D,Dersh D,Gidalevitz T,Argon Y

doi

10.1016/j.molcel.2014.01.004

subject

Has Abstract

pub_date

2014-02-20 00:00:00

pages

562-576

issue

4

eissn

1097-2765

issn

1097-4164

journal_volume

53

pub_type

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