Abstract:
:It has been known for some time that stimulation of heterotrimeric G protein-coupled receptors can cause cytoskeletal reorganization. A recent report in Developmental Cell demonstrates that the activation of a tyrosine kinase, C-terminal Src kinase, by heterotrimeric G protein subunits provides the trigger for Rho-dependent actin stress fiber formation.
journal_name
Mol Celljournal_title
Molecular cellauthors
Luttrell LMdoi
10.1016/s1097-2765(02)00551-8subject
Has Abstractpub_date
2002-06-01 00:00:00pages
1152-4issue
6eissn
1097-2765issn
1097-4164pii
S1097-2765(02)00551-8journal_volume
9pub_type
杂志文章相关文献
MOLECULAR CELL文献大全abstract::A recent paper by Gallagher et al. (2020) demonstrates that c-di-GMP controls spore formation in Streptomyces venezuelae through sequestering the sporulation sigma factor σWhiG and presents the crystal structure of a ternary complex between c-di-GMP, σWhiG, and its anti-sigma factor, RsiG. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2020.01.018
更新日期:2020-02-06 00:00:00
abstract::The anaphase-promoting complex/cyclosome (APC/C) regulates sister chromatid segregation and the exit from mitosis. Selection of most APC/C substrates is controlled by coactivator subunits (either Cdc20 or Cdh1) that interact with substrate destruction motifs--predominantly the destruction (D) box and KEN box degrons. ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.04.024
更新日期:2013-06-06 00:00:00
abstract::The subclass of cysteine proteases termed lysosomal cathepsins has long been thought to be primarily involved in end-stage protein breakdown within lysosomal compartments. Furthermore, few specific protein substrates for these proteases have been identified. We show here that cathepsin L functions in the regulation of...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(04)00209-6
更新日期:2004-04-23 00:00:00
abstract::Bcr-Abl is a dysregulated tyrosine kinase whose mechanism of activation is unclear. Here, we demonstrate that, like c-Abl, Bcr-Abl is negatively regulated through its SH3 domain. Kinase activity, transformation, and leukemogenesis by Bcr-Abl are greatly impaired by mutations of the Bcr coiled-coil domain that disrupt ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00274-0
更新日期:2003-07-01 00:00:00
abstract::We have used gene competition to distinguish between possible mechanisms of transcriptional activation of the genes of the human beta-globin locus. The insertion of a second beta-globin gene at different points in the locus shows that the more proximal beta gene competes more effectively for activation by the locus co...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)80014-3
更新日期:1997-12-01 00:00:00
abstract::The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their promoter structure, selectivity for either RNA polymerase (Pol) II or III, and because of their unique mechanism of termination that is tightly linked with the pro...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.07.003
更新日期:2013-08-22 00:00:00
abstract::Protein phase separation by low-complexity, intrinsically disordered domains generates membraneless organelles and links to neurodegeneration. Cellular prion protein (PrPC) contains such domains, causes spongiform degeneration, and is a receptor for Alzheimer's amyloid-β oligomers (Aβo). Here, we show that PrPC separa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.10.009
更新日期:2018-11-01 00:00:00
abstract::The proteolytic activation of the membrane-associated transcription factor pro-sigma(K) is controlled by a signal transduction pathway during sporulation in the bacterium Bacillus subtilis. The pro-sigma(K) processing enzyme SpoIVFB, a membrane-embedded metalloprotease, is held inactive by two other integral-membrane ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2006.05.019
更新日期:2006-07-07 00:00:00
abstract::The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas nuclease system is a powerful tool for genome editing, and its simple programmability has enabled high-throughput genetic and epigenetic studies. These high-throughput approaches offer investigators a toolkit for functional interrogation of not...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2017.09.017
更新日期:2017-10-05 00:00:00
abstract::Poly(ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational modification PAR from substrate NAD(+) to regulate multiple cellular processes. DNA breaks sharply elevate PARP-1 catalytic activity to mount a cell survival repair response, whereas persistent PARP-1 hyperactivation during severe genotoxic stress is...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.10.013
更新日期:2015-12-03 00:00:00
abstract::Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-γ (IFNγ) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. The inactivation of STAT1 occurs through tyrosine dephosphorylation by the tyrosine p...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.02.024
更新日期:2013-04-11 00:00:00
abstract::To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.05.028
更新日期:2012-06-08 00:00:00
abstract::ATP is required for nucleation of actin filament branches by Arp2/3 complex, but the influence of ATP binding and hydrolysis are poorly understood. We determined crystal structures of bovine Arp2/3 complex cocrystallized with various bound adenine nucleotides and cations. Nucleotide binding favors closure of the nucle...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.04.017
更新日期:2007-05-11 00:00:00
abstract::RNA editing in the mitochondria of kinetoplastids involves the addition and deletion of uridines at specific sites as directed by guide RNAs (gRNAs). Ample evidence shows that ribonucleoprotein (RNP) complexes carry out this posttranscriptional processing. One component of RNA editing complexes is REAP-1, a protein of...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(01)00231-3
更新日期:2001-04-01 00:00:00
abstract::Folding-defective proteins must be cleared efficiently from the endoplasmic reticulum (ER) to prevent perturbation of the folding environment and to maintain cellular proteostasis. Misfolded proteins engage dislocation machineries (dislocons) built around E3 ubiquitin ligases that promote their transport across the ER...
journal_title:Molecular cell
pub_type: 杂志文章,收录出版
doi:10.1016/j.molcel.2013.10.016
更新日期:2013-12-26 00:00:00
abstract::Transcriptional pausing by RNA polymerase (RNAP) plays an essential role in gene regulation. Pausing is modified by various elongation factors, including prokaryotic NusA, but the mechanisms underlying pausing and NusA function remain unclear. Alternative models for pausing invoke blockade events that precede transloc...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.09.018
更新日期:2011-11-18 00:00:00
abstract::The activity of RING finger ubiquitin ligases (E3) is dependent on their ability to facilitate transfer of ubiquitin from ubiquitin-conjugating enzymes (E2) to substrates. The G2BR domain within the E3 gp78 binds selectively and with high affinity to the E2 Ube2g2. Through structural and functional analyses, we determ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.05.010
更新日期:2009-06-26 00:00:00
abstract::In this issue of Molecular Cell, Roberts-Galbraith and colleagues report that a key cytokinetic regulator in fission yeast, Cdc15, is phosphorylated on numerous sites that collectively, but not individually, control its oligomerization state and its associations with the plasma membrane and interacting proteins. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.06.028
更新日期:2010-07-09 00:00:00
abstract::HAT1 is an essential gene in mammals that acetylates newly synthesized histone H4 and is involved in chromatin assembly and genome maintenance. In this issue of Molecular Cell, Gruber et al. (2019) show that HAT1 binds to and stimulates H4 gene expression in a growth-factor- and glucose-dependent manner. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2019.08.004
更新日期:2019-08-22 00:00:00
abstract::Trans-sialidases (TS) are GPI-anchored surface enzymes expressed in specific developmental stages of trypanosome parasites like Trypanosoma cruzi, the etiologic agent of Chagas disease, and T. brucei, the causative agent of sleeping sickness. TS catalyzes the transfer of sialic acid residues from host to parasite glyc...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(02)00680-9
更新日期:2002-10-01 00:00:00
abstract::The Mre11-Rad50-Xrs2 (MRX) complex is related to SMC complexes that form rings capable of holding two distinct DNA strands together. MRX functions at stalled replication forks and double-strand breaks (DSBs). A mutation in the N-terminal OB fold of the 70 kDa subunit of yeast replication protein A, rfa1-t11, abrogates...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.10.032
更新日期:2016-12-01 00:00:00
abstract::How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains unanswered today. Early biochemical and microscopic studies revealed the existence of chromatin domains and loops as a pervasive feature of interphase chromosomes, but the biological implications of such organizational features were...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2016.05.018
更新日期:2016-06-02 00:00:00
abstract::Metazoan spliceosomes exhibit an elaborate protein composition required for canonical and alternative splicing. Thus, the minimal set of proteins essential for activation and catalysis remains elusive. We therefore purified in vitro assembled, precatalytic spliceosomal complex B, activated B(act), and step 1 complex C...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.09.040
更新日期:2009-11-25 00:00:00
abstract::We have identified human MBT domain-containing protein L3MBTL2 as an integral component of a protein complex that we termed Polycomb repressive complex 1 (PRC1)-like 4 (PRC1L4), given the copresence of PcG proteins RING1, RING2, and PCGF6/MBLR. PRC1L4 also contained E2F6 and CBX3/HP1γ, known to function in transcripti...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.04.004
更新日期:2011-05-20 00:00:00
abstract::Salmonella force their way into nonphagocytic host intestinal cells to initiate infection. Uptake is triggered by delivery into the target cell of bacterial effector proteins that stimulate cytoskeletal rearrangements and membrane ruffling. The Salmonella invasion protein A (SipA) effector is an actin binding protein ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(04)00053-x
更新日期:2004-02-27 00:00:00
abstract::The role of the protein kinase Akt in cell migration is incompletely understood. Here we show that sphingosine-1-phosphate (S1P)-induced endothelial cell migration requires the Akt-mediated phosphorylation of the G protein-coupled receptor (GPCR) EDG-1. Activated Akt binds to EDG-1 and phosphorylates the third intrace...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(01)00324-0
更新日期:2001-09-01 00:00:00
abstract::Serine-arginine (SR) proteins are general splicing factors and can function through binding to exonic splicing enhancers (ESEs). SR proteins and several other mammalian splicing factors contain an arginine-serine-rich (RS) domain required to promote splicing. We have recently found that the ESE bound RS domain functio...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2004.10.021
更新日期:2004-11-05 00:00:00
abstract::Physical and genetic studies verify that the DNA binding domain of protein gpNu1 (which initiates packaging of phage lambda DNA) is a winged helix-turn-helix (w HTH) and that gpNu1 dimers bind sites that are brought close through DNA bending. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/s1097-2765(02)00536-1
更新日期:2002-05-01 00:00:00
abstract::The molecular structures of crossover (CO) and noncrossover (NCO) intermediates were determined by sequencing the products formed when a gapped plasmid was repaired using a diverged chromosomal template. Analyses were done in the absence of mismatch repair (MMR) to allow efficient detection of strand-transfer intermed...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.02.028
更新日期:2010-04-23 00:00:00
abstract::R loop, a transcription intermediate containing RNA:DNA hybrids and displaced single-stranded DNA (ssDNA), has emerged as a major source of genomic instability. RNaseH1, which cleaves the RNA in RNA:DNA hybrids, plays an important role in R loop suppression. Here we show that replication protein A (RPA), an ssDNA-bind...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2017.01.029
更新日期:2017-03-02 00:00:00