Abstract：
:How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains unanswered today. Early biochemical and microscopic studies revealed the existence of chromatin domains and loops as a pervasive feature of interphase chromosomes, but the biological implications of such organizational features were obscure. Genome-wide analysis of pair-wise chromatin interactions using chromatin conformation capture (3C)-based techniques has shed new light on the organization of chromosomes in interphase nuclei. Particularly, the finding of cell-type invariant, evolutionarily conserved topologically associating domains (TADs) in a broad spectrum of cell types has provided a new molecular framework for the study of animal development and human diseases. Here, we review recent progress in characterization of such chromatin domains and delineation of mechanisms of their formation in animal cells.
journal_name
Mol Celljournal_title
Molecular cellauthors
Dixon JR,Gorkin DU,Ren Bdoi
10.1016/j.molcel.2016.05.018subject
Has Abstractpub_date
2016-06-02 00:00:00pages
668-80issue
5eissn
1097-2765issn
1097-4164pii
S1097-2765(16)30181-2journal_volume
62pub_type
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