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A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly.

Abstract：

:RNA flow between organisms has been documented within and among different kingdoms of life. Recently, we demonstrated horizontal RNA transfer between honeybees involving secretion and ingestion of worker and royal jellies. However, how the jelly facilitates transfer of RNA is still unknown. Here, we show that worker and royal jellies harbor robust RNA-binding activity. We report that a highly abundant jelly component, major royal jelly protein 3 (MRJP-3), acts as an extracellular non-sequence-specific RNA-aggregating factor. Multivalent RNA binding stimulates higher-order assembly of MRJP-3 into extracellular ribonucleoprotein granules that protect RNA from degradation and enhance RNA bioavailability. These findings reveal that honeybees have evolved a secreted dietary RNA-binding factor to concentrate, stabilize, and share RNA among individuals. Our work identifies high-order ribonucleoprotein assemblies with functions outside cells and organisms.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Maori E,Navarro IC,Boncristiani H,Seilly DJ,Rudolph KLM,Sapetschnig A,Lin CC,Ladbury JE,Evans JD,Heeney JL,Miska EA

doi

10.1016/j.molcel.2019.03.010

subject

Has Abstract

pub_date

2019-05-02 00:00:00

pages

598-608.e6

issue

3

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(19)30184-4

journal_volume

74

pub_type

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