Abstract：
:Faithful propagation of specific chromatin states requires re-establishment of epigenetic marks after every cell division. How the original epigenetic signature is inherited after disruption during DNA replication is still poorly understood. Here, we show that the poly(ADP-ribose)-polymerase-1 (PARP1/ARTD1) is implicated in the maintenance of silent rDNA chromatin during cell division. We demonstrate that PARP1 associates with TIP5, a subunit of the NoRC complex, via the noncoding pRNA and binds to silent rRNA genes after their replication in mid-late S phase. PARP1 represses rRNA transcription and is implicated in the formation of silent rDNA chromatin. Silent rDNA chromatin is a specific substrate for ADP-ribosylation and the enzymatic activity of PARP1 is necessary to establish rDNA silencing. The data unravel a function of PARP1 and ADP-ribosylation that serves to allow for the inheritance of silent chromatin structures, shedding light on how epigenetic marks are transmitted during each cell cycle.
journal_name
Mol Celljournal_title
Molecular cellauthors
Guetg C,Scheifele F,Rosenthal F,Hottiger MO,Santoro Rdoi
10.1016/j.molcel.2012.01.024subject
Has Abstractpub_date
2012-03-30 00:00:00pages
790-800issue
6eissn
1097-2765issn
1097-4164pii
S1097-2765(12)00112-8journal_volume
45pub_type
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