Abstract:
:c-Jun, a major transcription factor in the activating protein 1 (AP-1) family of regulatory proteins, is activated by many physiologic and pathologic stimuli. However, whether c-jun is regulated by epigenetic modification of chromatin structure is not clear. We showed here that c-jun was transcriptionally repressed in response to osmotic stress via a truncated HDAC3 generated by caspase-7-dependent cleavage at aspartic acid 391. The activation of caspase-7, which is independent of cytochrome c release and activation of caspase-9 and caspase-12, depends on activation of caspase-8, which in turn requires MEK2 activity and secretion of FAS ligand. The cell apoptosis induced by the truncated HDAC3 or enhanced by c-Jun deficiency during osmotic stress was suppressed by exogenous expression of c-Jun, indicating that the downregulation of c-Jun by HDAC3-dependent transcriptional repression plays a role in regulating cell survival and apoptosis.
journal_name
Mol Celljournal_title
Molecular cellauthors
Xia Y,Wang J,Liu TJ,Yung WK,Hunter T,Lu Zdoi
10.1016/j.molcel.2007.01.005subject
Has Abstractpub_date
2007-01-26 00:00:00pages
219-32issue
2eissn
1097-2765issn
1097-4164pii
S1097-2765(07)00009-3journal_volume
25pub_type
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