Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults.

abstract：:Young rats were not able to expel adult N. brasiliensis infections even when the worms were damaged by antibodies and the young rats were given all the cellular components (sensitized lymphocytes and bone marrow cells) shown to be necessary for the expulsion of antibody-damaged worms from adult rats. In contrast, most...

journal_title：Clinical and experimental immunology

authors： Love RJ,Ogilvie BM

更新日期：1975-07-01 00:00:00

abstract：:In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic...

journal_title：Clinical and experimental immunology

authors： Eckhardt J,Döbbeler M,König C,Kuczera K,Kuhnt C,Ostalecki C,Zinser E,Mak TW,Steinkasserer A,Lechmann M

更新日期：2015-07-01 00:00:00

abstract：:Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-alpha), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 i...

journal_title：Clinical and experimental immunology

authors： Jongen-Lavrencic M,Peeters HR,Rozemuller H,Rombouts WJ,Martens AC,Vreugdenhil G,Pillay M,Cox PH,Bijser M,Brutel G,Breedveld FC,Swaak AJ

更新日期：1996-02-01 00:00:00

abstract：:A new antimitochondrial antibody (AMA) against an outer membrane associated antigen on liver mitochondria was detected by ELISA in sera from patients with primary biliary cirrhosis (PBC). This antibody was named anti-M9. There is evidence that it is a partial organ-specific antibody as shown by absorption studies usin...

journal_title：Clinical and experimental immunology

authors： Klein R,Berg PA

更新日期：1988-10-01 00:00:00

abstract：:Measles CF antibodies have been examined in the sera of patients with a variety of clinical disorders associated with the production of autoantibodies. Previous reports of high-titre reactions in DLE and chronic active hepatitis have been confirmed, the titres in the latter disorder being particularly elevated. Mean a...

journal_title：Clinical and experimental immunology

authors： Triger DR,Gamlen TR,Paraskevas E,Lloyd RS,Wright R

更新日期：1976-06-01 00:00:00

abstract：:The most likely source of autoantigens in systemic lupus erythematosus (SLE) is apoptotic material. Because increased levels of circulating apoptotic cells are found in SLE we wanted to investigate the capacity of serum from patients with SLE or other autoimmune or infectious diseases and normal healthy donors (NHD) t...

journal_title：Clinical and experimental immunology

authors： Bengtsson AA,Sturfelt G,Gullstrand B,Truedsson L

更新日期：2004-03-01 00:00:00

abstract：:There are lines of evidence that natural killer (NK) cells are sensitive to physical and psychological stress. Alterations in the immune system including NK cells are known to differ among tissues and organs. The effect of stress on the lung immune system, however, has not been well documented in spite of the fact tha...

journal_title：Clinical and experimental immunology

authors： Kanemi O,Zhang X,Sakamoto Y,Ebina M,Nagatomi R

更新日期：2005-01-01 00:00:00

abstract：:IFN-gamma is known to be a major inhibitor of IgE synthesis in vitro. Recent studies demonstrating reduced production of IFN-gamma in children and adults with atopic dermatitis and elevated serum IgE suggest a similar role for this cytokine in vivo. The reasons for this reduced IFN-gamma production are not known. One ...

journal_title：Clinical and experimental immunology

authors： Tang M,Kemp A

更新日期：1994-01-01 00:00:00

abstract：:The relation between the duration of bacterial infection and circulating immune complexes (CIC) level was evaluated using the C1q binding assay in a group of patients with well defined clinical sepsis. Fifty-four patients with endocarditis and 35 with post-open heart surgery mediastinitis were prospectively studied ov...

journal_title：Clinical and experimental immunology

authors： Pocidalo MA,Gibert C,Verroust P,Geniteau M,Adam C,Madec Y,Gaudebout C,Morel-Maroger L

更新日期：1982-03-01 00:00:00

abstract：:A system has been established to produce in vitro IgG specific for cell wall determinants of S. aureus by human peripheral blood mononuclear cells (PBMC). PBMC of healthy individuals, of patients with S. aureus infections and of patients with other bacterial infections were cultured for 12 days. In the culture superna...

journal_title：Clinical and experimental immunology

authors： Hauser C,Wilhelm JA,Matter L,Schopfer K

更新日期：1984-07-01 00:00:00

abstract：:Human thymic stromal lymphopoietin (TSLP) promotes CD4(+) T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8(+) T-cell proliferation, it is not clear whether TSLP acts directly on CD8(+) T cells. In this study, we show that human CD8(+...

journal_title：Clinical and experimental immunology

authors： Akamatsu T,Watanabe N,Kido M,Saga K,Tanaka J,Kuzushima K,Nishio A,Chiba T

更新日期：2008-10-01 00:00:00

abstract：:The effects of various cytokines on synthesis and microheterogeneity of carbohydrate structure of alpha 1-proteinase inhibitor (PI) and alpha-fetoprotein (AFP) in the human hepatoma cell lines Hep 3B and Hep G2 were studied. In both lines, crude cytokine preparations from LPS-activated human monocytes (CM) and several...

journal_title：Clinical and experimental immunology

authors： Mackiewicz A,Schultz D,Mathison J,Ganapathi M,Kushner I

更新日期：1989-01-01 00:00:00

abstract：:The precise factor responsible for the altered immunological reactivity and diminished inflammatory responses occurring in pregnancy is unknown. Recent observations implicate the pregnancy-associated alpha-2 glycoprotein (PAG). Using rosette assays for the detection of cells carrying Fc receptors and for the demonstra...

journal_title：Clinical and experimental immunology

authors： Persellin RH,Rhodes J

更新日期：1981-11-01 00:00:00

abstract：:Monoclonal antibodies anti-Ly 1, anti-Ly 2 and GK1.5 were applied to determine phenotypes of T cells within granulomas formed as a result of infection of mice with the facultative intracellular bacterium Listeria monocytogenes. Early in granuloma formation, equal numbers of Ly 1+, Ly 2+ and L3T4+ cells were found, T c...

journal_title：Clinical and experimental immunology

authors： Näher H,Sperling U,Takacs L,Hahn H

更新日期：1985-06-01 00:00:00

abstract：:alpha 1-Microglobulin (alpha 1-m) was purified by column chromatography from a supernatant fluid of cultured T and B lymphocytes stimulated with mitogens. This protein had a molecular weight of 33,000 as determined by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, migrated in the alpha 1-region on i...

journal_title：Clinical and experimental immunology

authors： Itoh Y,Kin K,Kasahara T,Sakurabayashi I,Kawai T,Shiori-Nakano K,Takagi K

更新日期：1979-07-01 00:00:00

abstract：:Post-traumatic splenectomy is associated with increased postoperative morbidity and mortality and long-term impairment of humoral and cellular immunity. Alternatives to surgery have been developed to minimize or avoid the immediate and/or long-term complications of splenectomy. Herein we investigated the long-term eff...

journal_title：Clinical and experimental immunology

authors： Theodorou GL,Mouzaki A,Tsiftsis D,Apostolopoulou A,Mougiou A,Theodori E,Vagianos C,Karakantza M

更新日期：2007-12-01 00:00:00

abstract：:The serum levels of TGF-beta1, measured by solid-phase ELISA, were determined to be significantly augmented in patients with both relapsing remitting (RR) and secondary chronic progressive (CP) MS compared with sex- and age-matched healthy controls. Moreover, in RR MS patients, the blood levels of the cytokine were fu...

journal_title：Clinical and experimental immunology

authors： Nicoletti F,Di Marco R,Patti F,Reggio E,Nicoletti A,Zaccone P,Stivala F,Meroni PL,Reggio A

更新日期：1998-07-01 00:00:00

abstract：:We report on the experience of establishing a national network for a quality control programme in evaluating CD4 cell counts in most Italian centres involved in the care of patients with HIV disease. The 68 centres were divided according to their geographical location into eight groups, and twice a year (tests A and B...

journal_title：Clinical and experimental immunology

authors： Pandolfi F,Alario C,Girardi E,Rava L,Ippolito G,Kunkl A,Aiuti F

更新日期：1998-03-01 00:00:00

abstract：:BALB/c mice made tolerant to A/J alloantigens by neonatal injection of (A/J x BALB/c)F1 spleen cells develop a host-versus-graft (HVG) disease due to the activation of donor B cells by a subset of host alloreactive helper T cells. We have investigated the effects of a single neonatal injection of the 145-2C11 anti-mou...

journal_title：Clinical and experimental immunology

authors： Wissing M,Marchant A,Moser M,Flamand V,Leo O,Abramowicz D,Urbain J,Goldman M

更新日期：1991-02-01 00:00:00

abstract：:The sera of seven out of eight patients with Herpes gestationis contained a factor which fixed C3 but not detectable amounts of immunoglobulin (Ig) on the basement membrane zone (BMZ) of normal human skin. Using C2-deficient human serum and C4-deficient guinea-pig serum, fixation was shown to be dependent upon activat...

journal_title：Clinical and experimental immunology

authors： Carruthers JA,Ewins AR

更新日期：1978-01-01 00:00:00

abstract：:We previously demonstrated that high levels of IL-6/sIL-6R complexes are present in sera of patients with systemic juvenile idiopathic arthritis (s-JIA) and that the amount of IL-6 estimated in the IL-6/sIL-6R complexes is markedly higher than that measured by the B9 assay. Here, we show that two additional bioassays,...

journal_title：Clinical and experimental immunology

authors： Pignatti P,Ciapponi L,Galle P,Hansen MB,Massa M,Meazza C,Paonessa G,Novick D,Ciliberto G,Martini A,De Benedetti F

更新日期：2003-02-01 00:00:00

abstract：:The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect...

journal_title：Clinical and experimental immunology

authors： Tecklenborg J,Clayton D,Siebert S,Coley SM

更新日期：2018-05-01 00:00:00

abstract：:Protection against intracellular pathogens such as Mycobacterium leprae is critically dependent on the function of NK cells at early stages of the immune response and on Th1 cells at later stages. In the present report we evaluated the role of IL-18 and IL-13, two cytokines that can influence NK cell activity, in the ...

journal_title：Clinical and experimental immunology

authors： de la Barrera S,Finiasz M,Fink S,Ilarregui J,Aleman M,Olivares L,Franco MC,Pizzariello G,del Carmen Sasiain M

更新日期：2004-01-01 00:00:00

abstract：:Previous studies show that endoplasmic reticulum-associated aminopeptidase (ERAP1/ERAP2) and runt-related transcription factor 3 (RUNX3) gene polymorphisms are associated with AS (ankylosing spondylitis) in European Caucasians. However, contradictory results were reported in different Asian populations. The purpose of...

journal_title：Clinical and experimental immunology

authors： Su W,Du L,Liu S,Deng J,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2018-07-01 00:00:00

abstract：:Recently we reported that monocyte phagocytosis and chemotaxis are impaired in X-linked agammaglobulinaemia (XLA) and common variable immunodeficiency (CVI) patients. Few data exist on the in vivo expression of receptors for the constant region of immunoglobulin (IgG) (Fc gammaR) and complement receptors (CR) in these...

journal_title：Clinical and experimental immunology

authors： Amoras AL,da Silva MT,Zollner RL,Kanegane H,Miyawaki T,Vilela MM

更新日期：2007-12-01 00:00:00

abstract：:The possible role of cytokines in leprosy reactions was investigated by analysing the levels of tumour necrosis factor (TNF) and interleukin-1 (IL-1) in serum samples from 39 leprosy patients, 22 of them presenting either type I (upgrading) or type II (ENL) reactions. Fifty per cent of the patients showed elevated con...

journal_title：Clinical and experimental immunology

authors： Sarno EN,Grau GE,Vieira LM,Nery JA

更新日期：1991-04-01 00:00:00

abstract：:Autoimmune diseases are either tissue-specific like multiple sclerosis (MS) or multisystemic like systemic lupus erythematosus (SLE), although clinically both exhibit common features. To gain insight into the properties of the genes involved in each disease we have investigated the gene expression signature of periphe...

journal_title：Clinical and experimental immunology

authors： Mandel M,Gurevich M,Pauzner R,Kaminski N,Achiron A

更新日期：2004-10-01 00:00:00

abstract：:Human thyroid epithelial cells (thyrocytes) express HLA Class II molecules in autoimmune thyroid diseases (ATD). Normal thyrocytes do not express Class II, but can be induced to do so by culture with interferon-gamma (gamma-IFN). We have examined HLA-D subregion expression in sections and monolayers of thyroid by indi...

journal_title：Clinical and experimental immunology

authors： Todd I,Pujol-Borrell R,Abdul-Karim BA,Hammond LJ,Feldmann M,Bottazzo GF

更新日期：1987-09-01 00:00:00

abstract：:Intestinal T cells have a unique state of activation and differentiation which might specifically affect or be affected by HIV infection. Lymphocyte subsets in the peripheral blood are well characterized, but our knowledge about intestinal lymphocytes in HIV infection is incomplete. We therefore analysed lymphocytes i...

journal_title：Clinical and experimental immunology

authors： Schneider T,Ullrich R,Bergs C,Schmidt W,Riecken EO,Zeitz M

更新日期：1994-03-01 00:00:00

abstract：:A serial prospective study of cell-mediated immunity to rabbit liver-specific lipoprotein (RLSP) has been done in 26 patients with acute viral hepatitis (AH) (18 HBsAg+ and eight HBsAg-) using a lymphocyte transformation test. An increased stimulation index was recorded in 56% of HBsAg+ cases and in 63% of the HBsAg- ...

journal_title：Clinical and experimental immunology

authors： Ortona L,Laghi V,Cauda R,Nervo P

更新日期：1980-12-01 00:00:00