The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes.

Abstract:

:cDNAs of Anopheles gambiae Defensin 2 (AgDef2), Defensin 3 (AgDef3) and Defensin 4 (AgDef4), identified in the genome sequence, have been characterized and their expression profiles investigated. In contrast to both typical defensins and insect antimicrobial peptides generally, the newly identified defensins were not upregulated with acute-phase kinetics following immune challenge in insects or cell culture. However, mRNA abundance of AgDef2, AgDef3 and AgDef4 increased significantly during the larval stages. Promoter analysis of all three genes failed to identify putative immune response elements previously identified in other mosquito defensin genes. As previous studies failed to identify these larval-specific defensins, it seems likely that further antimicrobial peptide genes with nontypical expression profiles will be identified as more genome sequences become available.

journal_name

Insect Mol Biol

journal_title

Insect molecular biology

authors

Meredith JM,Hurd H,Lehane MJ,Eggleston P

doi

10.1111/j.1365-2583.2008.00786.x

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

103-12

issue

2

eissn

0962-1075

issn

1365-2583

pii

IMB786

journal_volume

17

pub_type

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