Abstract:
:A birth-and-death evolutionary model for odorant receptor gene repertoires presumes the creation of repertoires with the capacity for high-level diversity and rapid ligand specificity change. This changes the recognised odour space, directly affecting fitness-related behaviours and ultimately affecting adaptation to new environments and resources. The proximate molecular mechanisms underlying the tuning of odorant receptor repertoires, and thus peripheral olfaction, are unclear. In the present study, we report a concrete example of this model of odorant receptor evolution leading to rapid changes in receptor tuning that leave the peripheral neuronal circuitry intact. We identified a conserved odorant receptor gene in mosquitoes, Or8, which in Culex quinquefasciatus underwent a duplication and inversion event. The paralogues differ in only minor structural changes manifesting at the C-terminus. We assessed the specificity of the paralogous odorant receptors and receptor neurones. We found that the functional tuning of the receptor was indeed reflected in minor differences in amino acid structure. Specifically, we found that enantiomeric specificity of these mosquito Or8 paralogues relies on eight C-terminal amino acids encoded in the final exon of the gene; thus, the birth of a paralogous odorant receptor can change the tuning of the peripheral olfactory system.
journal_name
Insect Mol Bioljournal_title
Insect molecular biologyauthors
Hill SR,Majeed S,Ignell Rdoi
10.1111/imb.12176subject
Has Abstractpub_date
2015-08-01 00:00:00pages
491-501issue
4eissn
0962-1075issn
1365-2583journal_volume
24pub_type
杂志文章abstract::The fall armyworm, Spodoptera frugiperda, consists of two host strains (rice and corn) that differ in developmental, physiological and behavioural characteristics. However, because the strains are morphologically indistinguishable the investigation of strain-specific behaviour, particularly in the wild, is very diffic...
journal_title:Insect molecular biology
pub_type: 杂志文章
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journal_title:Insect molecular biology
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journal_title:Insect molecular biology
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journal_title:Insect molecular biology
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journal_title:Insect molecular biology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Insect molecular biology
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journal_title:Insect molecular biology
pub_type: 杂志文章
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journal_title:Insect molecular biology
pub_type: 杂志文章
doi:10.1111/imb.12117
更新日期:2014-12-01 00:00:00
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journal_title:Insect molecular biology
pub_type: 杂志文章,评审
doi:10.1111/imb.12282
更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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更新日期:2016-04-01 00:00:00
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journal_title:Insect molecular biology
pub_type: 杂志文章
doi:10.1111/imb.12096
更新日期:2014-08-01 00:00:00
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journal_title:Insect molecular biology
pub_type: 杂志文章
doi:10.1111/imb.12181
更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Insect molecular biology
pub_type: 杂志文章
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journal_title:Insect molecular biology
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journal_title:Insect molecular biology
pub_type: 杂志文章
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