Abstract：
BACKGROUND:The clinicopathological roles and relationships of hTERT, p21 and p53 proteins have not been studied in depth in colorectal cancer. The aim of the present study is to investigate the clinicopathological roles of expression of hTERT protein expression and its relationship with the expression of p21 and p53 proteins in a large cohort of patients with colorectal adenocarcinoma. MATERIALS AND METHODS:Expressions of hTERT, p21 and p53 proteins were investigated in 188 patients with colorectal adenocarcinomas by immunohistochemistry. The findings were correlated with the clinicopathological features and survival data of colorectal adenocarcinomas. RESULTS:hTERT, p53 and p21 proteins were detected in 63%, 100% and 62% of the patients with colorectal carcinoma. High level of hTERT protein expression was noted in patients with metastases (p = 0.038) and in patients with rectal cancer (p = 0.046). Loss or low level of p21 protein was often noted in non-mucinous colorectal adenocarcinoma when compared with mucinous adenocarcinoma (p = 0.001). Furthermore, p53 expression was more frequently noted in non-mucinous adenocarcinoma (p = 0.001). The level of expression of p21 protein was positively correlated with expression of level of hTERT protein (p = 0.00001). The survival of the patients was related to staging (p = 0.001) and p53 protein expression (p = 0.038) of the tumours. CONCLUSIONS:hTERT protein expression is an indicator of the biological aggressiveness of the cancer. The level of expression of the protein was also related to the distal location and level of p21 expression of the tumours.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Lam AK,Ong K,Ho YHdoi
10.1007/s00384-008-0455-7subject
Has Abstractpub_date
2008-06-01 00:00:00pages
587-94issue
6eissn
0179-1958issn
1432-1262journal_volume
23pub_type
杂志文章abstract：BACKGROUND:ERAS implementation improved outcomes in patients undergoing colorectal surgery. The process of incorporating this pathway in clinical practice may be challenging. This observational study investigated the impact of systematic ERAS implementation on surgical outcomes in patients undergoing colorectal resecti...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,多中心研究
doi：10.1007/s00384-019-03496-8
更新日期：2020-03-01 00:00:00
abstract：:A retrospective study of 87 patients, subjected to colostomy closure between 1976 and 1987, was conducted in order to evaluate the role of 8 potential risk factors on morbidity and mortality. Possible risk factors were age greater than 65 years, presence of hypoalbuminaemia (less than 3.0 gr%), anaemia (Hb less than 1...
journal_title：International journal of colorectal disease
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更新日期：1990-05-01 00:00:00
abstract：PURPOSE:There are no published data or guidelines on whether the same anti-tumor-necrosis factor (TNF) agents used preoperatively or different anti-TNF agents are preferable to treat postoperative recurrence. Our aim was to compare the efficacy of the consistent vs. switched anti-TNF approaches in patients with recurre...
journal_title：International journal of colorectal disease
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更新日期：2016-11-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2002-01-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2013-11-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2017-05-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
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更新日期：2011-10-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-007-0275-1
更新日期：2007-09-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
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journal_title：International journal of colorectal disease
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更新日期：2006-09-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2015-07-01 00:00:00
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journal_title：International journal of colorectal disease
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journal_title：International journal of colorectal disease
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journal_title：International journal of colorectal disease
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更新日期：2013-07-01 00:00:00
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journal_title：International journal of colorectal disease
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pub_type： 杂志文章,meta分析
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更新日期：2016-05-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
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journal_title：International journal of colorectal disease
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更新日期：2010-04-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：1998-01-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2005-11-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
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更新日期：2016-07-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2008-07-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：1990-08-01 00:00:00
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更新日期：2021-01-01 00:00:00
