Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy.

Abstract:

BACKGROUND:The purpose of this study was to identify clinical and pathological parameters to improve prediction of disease-free survival (DFS) and overall survival (OS) in patients treated with neoadjuvant chemoradiotherapy for rectal cancer. METHODS:Between July 1995 and May 2007, 148 patients with primary rectal adenocarcinoma received neoadjuvant chemoradiotherapy followed by mesorectal excision. Preoperative treatment included various protocols, UFT and leucovorin (28%) and oxaliplatin-based chemotherapy (72%). Clinical and pathological variables were evaluated in relation to patient outcomes. RESULTS:Thirteen percent of patients achieved a complete pathologic response. No response or minimal response as defined by Dworak (Tumor Regression Grade 0/1) was observed in 30 patients (20%). At a median follow-up of 37 months, the 3-year DFS and OS were 64% and 83%, respectively. Pre-treatment serum carcinoembryonic antigen (CEA) level

journal_name

Int J Colorectal Dis

authors

Moreno García V,Cejas P,Blanco Codesido M,Feliu Batlle J,de Castro Carpeño J,Belda-Iniesta C,Barriuso J,Sánchez JJ,Larrauri J,González-Barón M,Casado E

doi

10.1007/s00384-009-0682-6

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

741-8

issue

7

eissn

0179-1958

issn

1432-1262

journal_volume

24

pub_type

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