Abstract：
:A combined manometric and radioisotope study is described which was designed to investigate the motility characteristics of induced defaecation in the colon, rectum and anal canal, in patients with severe constipation. Five women with severe idiopathic constipation, aged 30-45 years, were studied. A multiple channel water-perfused manometric tube was placed colonoscopically into either the whole colon or left colon to monitor pressure activity. In two whole-colon studies, 5.5 MBq 111In DTPA and later 9 MBq 99mTc DTPA were instilled into the colon to monitor the transit of colonic contents in response to two separate stimuli. Motor activity was initiated on both occasions by intraluminal instillation of 5.5 mg bisacodyl. In the whole-colonic studies a right colonic stimulus initiated multiple high-pressure peristaltic waves which traversed the entire length of the colon. The bowel was then refractory to a second stimulus at the splenic flexure. In the five left colonic studies, a stimulus at the splenic flexure produced high-pressure peristaltic waves which proceeded distally, and which included a rise in rectal pressure. The anal canal relaxed simultaneously with the onset of peristalsis high in the left colon, and remained relaxed until the pressure wave reached the anus and bowel content had been expelled. In both types of study high-pressure waves corresponded to the effective transport of radioisotope. The constipated patients showed a coordinated motor response to the stimulus.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Kamm MA,van der Sijp JR,Lennard-Jones JEdoi
10.1007/BF00341220subject
Has Abstractpub_date
1992-12-01 00:00:00pages
197-201issue
4eissn
0179-1958issn
1432-1262journal_volume
7pub_type
杂志文章abstract：BACKGROUND:Up to 25% of colorectal cancers present with bowel obstruction. Metal stents (MS) can provide a bridge to surgery by relieving obstruction and allowing the subject's condition to improve pre-operatively. METHODS:Hospital Episode Statistics (HES) is a database of all NHS funded secondary care episodes in Eng...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-019-03302-5
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:ERAS implementation improved outcomes in patients undergoing colorectal surgery. The process of incorporating this pathway in clinical practice may be challenging. This observational study investigated the impact of systematic ERAS implementation on surgical outcomes in patients undergoing colorectal resecti...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,多中心研究
doi：10.1007/s00384-019-03496-8
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE/BACKGROUND:Signals for the expression of the peptide growth factors epidermal growth factor and transforming growth factor-alpha (TGFalpha) in the gastrointestinal mucosa are largely unknown. We have shown earlier that extrinsic afferents in the gastrointestinal tract induce TGFalpha expression in colonic muc...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
abstract：PURPOSE:Published multigene classifiers suggesting outcome prediction for patients with stage UICC II colon cancer have not been translated into a clinical application so far. Therefore, we aimed at validating own and published gene expression signatures employing methods which enable their reconstruction in routine di...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-011-1176-x
更新日期：2011-07-01 00:00:00
abstract：:Desmoids are of major concern in patients with familial adenomatous polyposis (FAP) besides the cancer risk. We estimated the risk for desmoid tumours and the results of their treatment in the Finnish Polyposis Registry. The analysis included 202 FAP patients, of whom 169 had undergone colectomy. Desmoids were observe...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
abstract：BACKGROUND/AIMS:Laterally spreading tumors (LSTs) are being increasingly reported nowadays. The aims of this study were to analyze the clinicopathologic characteristics and to identify the risk factors of malignancy in patients with LSTs by morphological subclassification. PATIENTS AND METHODS:The authors retrospectiv...
journal_title：International journal of colorectal disease
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更新日期：2013-12-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2017-02-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Patients with Lynch syndrome (LS) are at an increased risk of developing gastric cancer. In 2010, a guideline that recommended to screen all patients for Helicobacter pylori was implemented in the Netherlands. H. pylori is an important risk factor in the development of gastric cancer in the general populatio...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2002-07-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2260-4
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVES:To compare purse-string skin closure (PSC) and linear skin closure (LSC) techniques in patients undergoing stoma closure METHODS: We conducted a systematic review of literature and meta-analysis of outcomes according to PRISMA statement standards to compare PSC and LSC techniques in stoma closure. Trial sequ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析,评审
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更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:In rectal cancer, prediction of tumor response and pathological complete response (pCR) to neoadjuvant treatment could contribute to refine selection of patients who might benefit from a delayed- or no-surgery approach. The aim of this study was to explore the association of clinical and molecular characteri...
journal_title：International journal of colorectal disease
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更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The functional outcome and quality of life after sphincter-saving operations for ulcerative colitis have not been previously assessed in Indian patients whose dietary habits and socio-cultural practices differ considerably from those in western countries. PATIENTS AND METHODS:Between 1996 and 2002, we perfo...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-010-0974-x
更新日期：2010-08-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2009-10-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2017-08-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00337583
更新日期：1995-01-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2008-06-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2011-09-01 00:00:00
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更新日期：2009-11-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
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更新日期：2010-07-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2002-03-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析,评审
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更新日期：2015-04-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析
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更新日期：2020-01-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2017-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Pancreatic stellate cells (PSCs) play a key role in the development of pancreatic fibrosis. The molecular mechanisms underlying their activation in response to profibrogenic mediators, however, are largely unknown. Extending previous studies on the transcriptional regulation of PSC activation, we ha...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-003-0565-1
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:To clarify the risk factors of lateral pelvic lymph node (LPLN) metastasis of rectal cancer, we examined associations between LPLN status and clinicopathological factors including LPLN status diagnosed by computed tomography (CT). METHODS:We reviewed a total of 210 patients with advanced rectal cancer, of w...
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更新日期：2009-09-01 00:00:00
