Abstract:
PURPOSE:The main operative method in familial adenomatous polyposis (FAP) patients is restorative proctocolectomy with "J"-shaped pouch and temporary loop ileostomy. The aim of the study was the analysis of the frequency of the dysplasia and inflammation in the intestinal pouch and prognosis of the clinical course in FAP patients after restorative proctocolectomy. METHODS:A group of 165 FAP patients (86 females and 79 males, mean age 22.49 ± 12) subjected to a restorative proctocolectomy in the years 1985-2009 was analyzed. Clinical data coming from follow-up observation in the period of 2004-2009 were evaluated. In all patients, clinical examination and endoscopy with polypectomy and/or biopsy of pouch mucosa were done. RESULTS:The mean time of pouchitis occurrence after an ileal pouch-anal anastomosis was 6 months. Mean time for low-grade dysplasia was 14 months. The time difference of low-grade dysplasia after the above procedure as compared to pouchitis alone was substantial. Mean time for high-grade dysplasia was 16 months and for neoplasia even 19 months. It was estimated that early pouchitis happening within the first year after surgery occurs in 5% of patients, low-grade dysplasia 4 years later in 7% of cases, high-grade dysplasia 7 years later in around 10% of patients and neoplasia 14 years after surgery in 15% of cases. CONCLUSIONS:In conclusion, the Polyposis Registry encompassing whole country is the best way of controlling FAP patients. The regular lifelong endoscopic monitoring gives the opportunity of the early detection of the dysplasia and can protect against neoplasia.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Banasiewicz T,Marciniak R,Kaczmarek E,Krokowicz P,Paszkowski J,Lozynska-Nelke A,Gronek P,Plawski A,Drews Mdoi
10.1007/s00384-011-1241-5subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1197-203issue
9eissn
0179-1958issn
1432-1262journal_volume
26pub_type
杂志文章abstract:BACKGROUND AND AIMS:Rectovaginal fistulas in patients with Crohn's disease are difficult to resolve, and surgical failure is very frequent. Recent studies have shown that adult stem cells extracted from certain tissues, such as adipose tissue, can develop into different tissues, such as muscle. PATIENT AND METHODS:We ...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-003-0490-3
更新日期:2003-09-01 00:00:00
abstract::Polyps in the stomach and duodenum are frequently found in familial adenomatous polyposis. Cancer arising from some of these polyps may be an important cause of death in patients who have had large bowel resections. This study aims to determine the nature and distribution of foregut polyps in Chinese patients. Twenty-...
journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
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更新日期:2008-10-01 00:00:00
abstract:PURPOSE:Bile acid malabsorption (BAM) is a common cause of diarrhoea in Crohn's disease (CD) patients with ileal resection. BAM is usually diagnosed by selenium-labelled homotaurocholic acid test (75SeHCAT) but its availability is limited. Consequently, a large proportion of patients either remain undiagnosed or subjec...
journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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更新日期:2008-04-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2013-10-01 00:00:00
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更新日期:2019-05-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:International journal of colorectal disease
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pub_type: 临床试验,杂志文章
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更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-11-01 00:00:00