Abstract:
PURPOSE:Fecal incontinence (FI) is a debilitating condition that can be socially and personally incapacitating. A broad range of treatment options, often stepwise, are available, depending on severity. This prospective study reports a large single-centered series of patients who have benefited of temperature-controlled radio frequency (Secca) energy delivered to the anal canal. MATERIAL AND METHODS:This investigation was a single-center, nonrandomized, prospective, clinical study of a single patient group with each serving as the control. All patients had experienced FI for at least 3 months and had attempted, but were not satisfied, with the results of medical and/or surgical therapies. The study aims to evaluate changes in FI symptom scores and quality of life between the baseline and follow-up intervals. RESULTS:Between March 2005 and March 2006, 15 Secca procedures were performed. All 15 patients were alive and in contact with the investigational site at time of 12 months. There were no long term complications. The mean Wexner score improved from 14.07 (+/-4.5) at baseline to 12.33 (+/-4.6) at 1 year (p=0.02). The mean fecal incontinence quality of life of life score was only improved in the depression subscore. There were no changes in endoanal ultrasound and anorectal manometry. CONCLUSION:This prospective trial confirmed the safety of the Secca procedure. Although we demonstrated a significant improvement in the Wexner Score, these clinical results have to be mitigated because most patients remained in the moderate incontinences category as defined by the scoring system and did not improved their quality of life excepted in the depression subscore.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Lefebure B,Tuech JJ,Bridoux V,Gallas S,Leroi AM,Denis P,Michot Fdoi
10.1007/s00384-008-0514-0subject
Has Abstractpub_date
2008-10-01 00:00:00pages
993-7issue
10eissn
0179-1958issn
1432-1262journal_volume
23pub_type
临床试验,杂志文章abstract::Division of the inferior mesenteric artery flush with the aorta (high tie) allows a tension-free anastomosis in distal colorectal resections but may also diminish the blood supply. Tissue oxygen tension was measured proximal to the resection margin before and after either low or high division of the inferior mesenteri...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/BF00337583
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Inpatients developing upper gastrointestinal (GI) haemorrhage are at increased risk of death. This study was performed to elucidate differences in inpatients and outpatients. PATIENTS/METHODS:Three hundred and sixty-two patients who needed esophagogastroduodenoscopy for upper GI bleeding were ident...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-004-0642-0
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:The functional outcome and quality of life after sphincter-saving operations for ulcerative colitis have not been previously assessed in Indian patients whose dietary habits and socio-cultural practices differ considerably from those in western countries. PATIENTS AND METHODS:Between 1996 and 2002, we perfo...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-010-0974-x
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Gastrointestinal cancers belong to the most important causes of cancer death in the Western world. Because cure can be achieved only by complete surgical removal of the tumor, and most patients have metastasis at the time point of diagnosis, the majority of patients receive chemotherapy. DISCUSSION:Indicati...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
doi:10.1007/s00384-003-0496-x
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:The aim of the study was to determine the spatiotemporal expression of Wnt5a during hindgut and anorectum development in human embryos and to explore the possible role of Wnt5a during the morphogenesis of the human hindgut and anorectum. MATERIALS AND METHODS:The embryos (n = 107) were sectioned serially and s...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-011-1191-y
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:Kras mutations are negative predictors of anti-EGFR therapy, occurring in 40% of colorectal carcinomas (CRCs). Point substitutions in codon 12 or 13 are the most frequent mutations in Kras, but multiple mutations (MMs) in other codons can also develop. Few data exist on MMs with regard to their frequency and th...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
doi:10.1007/s00384-011-1238-0
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:Stage II colon cancer (CC) represents a challenging scenario for the choice of adjuvant chemotherapy; here, histologic factors need to be weighed up to establish the risk of recurrence. Tumor budding (TB) has recently been indicated as a confident predictor of clinical outcome in CC. Likewise, the presence of p...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-019-03279-1
更新日期:2019-05-01 00:00:00
abstract:UNLABELLED:Patients with rectal cancer may develop local recurrence despite cancer resection plus treatment with high dose radiation therapy. In this report, symptomatic patients received benefit from repeat resection. The morbidity and mortality can be maintained at an acceptable level with meticulous dissections and ...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s003840050049
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The aim of this study was to determine the detection rate of polyps using zoom chromoendoscopy (ZE) compared with standard video colonoscopy. PATIENTS AND METHODS:End-to-end colonoscopies were performed in 50 patients by two different endoscopists blinded for each other's results. Lesions detected ...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-005-0052-y
更新日期:2006-09-01 00:00:00
abstract:AIM:This study aims to evaluate the prognostic value of CD45RO(+) tumor-infiltrating lymphocytes (TILs) in locally advanced rectal cancer treated with 30 Gy/10 fraction (10 f) neoadjuvant radiotherapy. METHODS:This retrospective study involved 185 patients with locally advanced rectal cancer who underwent 30 Gy/10 f n...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-015-2226-6
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Use of biosutures in animal models of colonic anastomoses is associated with decreased adhesions without affecting anastomotic strength. This study aimed to evaluate the effect of biosutures on colonic anastomoses kept free of adhesions by peritoneal instillation of icodextrin 4%. METHODS:Three types of coloni...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-010-0952-3
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to prospectively compare rectal resection (RR) with colonic resection on sexual, urinary and bowel function and quality of life in both short-term and long-term. METHODS:Eighty-three patients who underwent RR were compared to 53 patients who underwent a colonic resection leaving t...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-011-1288-3
更新日期:2011-12-01 00:00:00
abstract::Continence following the gracilis stimulated neosphincter reconstruction after total rectal excision is inferior to that obtained in the presence of an intact anal canal. We describe a modification of the alpha loop in which the tendon is brought through the belly of the gracilis muscle. The results in three patients ...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/BF00292246
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Dextran sulfate sodium (DSS) induced colitis exhibits a predominantly NF-kappaB dependent proinflammatory cytokine profile and shares similarities with human inflammatory bowel disease (IBD). Lamina propria macrophages of IBD patients display elevated levels of NF-kappaB p65. Knowing the role of NF-...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-001-0366-3
更新日期:2002-07-01 00:00:00
abstract:INTRODUCTION:A multidisciplinary tertiary service for adolescents with inflammatory bowel disease (IBD) was commenced in April 2008, aiming to provide specialist treatment for adolescent patients and bridge the gap between existing paediatric and adult surgical services. A single laparoscopic colorectal surgeon who nor...
journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
doi:10.1007/s00384-010-1058-7
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:The objective of the study is to assess the efficacy of vital bulbocavernosus graft transposition in the treatment of rectovaginal fistula. MATERIALS AND METHODS:From March 2003 to October 2007, nine consecutive patients diagnosed with rectovaginal fistula were refereed to our institute. All patients were tr...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-009-0720-4
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:Whether malignant colorectal obstruction (MCO) after one-stage curative surgery without preoperative decompression has a poor prognosis remains unclear. We assessed long-term outcomes of one-stage surgery without preoperative decompression for stage II/III MCO. METHODS:We retrospectively enrolled patients with...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-019-03413-z
更新日期:2019-11-01 00:00:00
abstract:AIMS:This study assesses the value of endorectal ultrasound (ERUS)-directed biopsy in detecting local recurrence of rectal cancer. METHODS:We reviewed the records of patients undergoing ERUS by a single surgeon for surveillance after treatment of rectal adenocarcinoma. Lesions suggestive of local recurrence underwent ...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-005-0785-7
更新日期:2006-04-01 00:00:00
abstract:AIM:The aim of this experimental study was to investigate the effect of intraperitoneal administration of oxaliplatin on the healing of colonic anastomoses when injected immediately after colon resection. MATERIALS AND METHODS:Thirty male Wistar rats were used. During the operation, the rats were randomized to two gro...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-008-0538-5
更新日期:2008-12-01 00:00:00
abstract::We assessed the reliability of anorectal angle (ARA) measurement as an index of fecal incontinence. The "posterior" ARA was measured at rest, squeezing, and straining in 69 continent and 82 incontinent subjects all complaining of various evacuation dysfunctions. The two groups were homogeneous with regard to sex distr...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s003840050198
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:The main operative method in familial adenomatous polyposis (FAP) patients is restorative proctocolectomy with "J"-shaped pouch and temporary loop ileostomy. The aim of the study was the analysis of the frequency of the dysplasia and inflammation in the intestinal pouch and prognosis of the clinical course in F...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-011-1241-5
更新日期:2011-09-01 00:00:00
abstract::The biomechanical properties and intestinal wall composition of left colon were studied in 4-month-old, 14-month-old, and 27-month-old male rats. The hydroxyproline content and hydroxyproline concentration in old rats were increased by 36% and 26%, respectively, compared with young rats and by 20% and 17%, respectivel...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/BF00341292
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Collagenous colitis is a chronic inflammatory bowel disease of unknown origin. In some cases of collagenous colitis, histomorphological features are comparable to other inflammatory bowel diseases. AIM:To assess functional NOD2/CARD15 polymorphisms for the susceptibility to collagenous colitis in a case-con...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-006-0158-x
更新日期:2007-04-01 00:00:00
abstract:PURPOSE:Surgical site infections (SSI) cause excess morbidity and mortality in modern surgery. Several different approaches to reduce the incidence of SSI have been investigated with variable results. METHOD:This is to our knowledge the first systematic randomized evaluation in patients undergoing laparotomy in viscer...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00384-010-0884-y
更新日期:2010-05-01 00:00:00
abstract::The aim of this study was to develop a method by which rectal and colonic activity could be examined during defaecation under physiological conditions, in order to evaluate whether the colon plays a role in defaecation. Subjects presented to the Nuclear Medicine department on the day following ingestion of oral In-111...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/BF00341204
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:As angiogenesis is one of the key steps in tumor growth, invasion, and metastasis, antiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. We investigated the cytotoxic, anti-adhesive, and anti-invasive effects of angiostatin in vitro and on intraperitoneal tumor growth in a ...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-005-0040-2
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide and the fourth leading cause of cancer-related deaths. This article reviews the epidemiology, risk factors, pathogenesis, and prognosis of CRC with special emphasis on advances in the management of CRC over the past decade. METHOD...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
doi:10.1007/s00384-014-1928-5
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:Although the effectiveness of antiemetic therapy for colorectal cancer chemotherapy has improved with further drug development, some patients still suffer from chemotherapy-induced nausea and vomiting (CINV) even with only 5-hydroxytryptamine-3 receptor antagonist and dexamethasone. The present study investigat...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-020-03731-7
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:The aim was to evaluate erectile and urinary function of male patients with rectal cancer treated by neoadjuvant (NA) chemoradiotherapy (CRT) or NA chemotherapy only. METHODS:In this prospective randomized trial (ClinicalTrials.gov NCT01211210; "FOWARC"), we included 102 men who received NA therapy for stage...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00384-016-2605-7
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:The hypothesis in this study was that anaemia prior to surgery and perioperative red blood cell transfusion increases the risk for recurrence and overall mortality in patients with stages I-III colorectal cancer after abdominal resection with curative intent. METHODS:This is a Swedish single centre retrospecti...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-016-2678-3
更新日期:2017-02-01 00:00:00