The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence.

abstract：PURPOSE:Serological tumor markers are routinely used to monitor tumor onset and progression. In colorectal carcinoma (CRC), the carcinoembryonic antigen (CEA) is roughly elevated in 50% of patients at initial diagnosis. Soluble ICAM-1 (sICAM-1) is elevated in different cancers. The aim of this study was to evaluate the...

journal_title：International journal of colorectal disease

authors： Schellerer VS,Langheinrich MC,Zver V,Grützmann R,Stürzl M,Gefeller O,Naschberger E,Merkel S

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Although the regional lymph node status is essential for staging of colorectal cancer, the importance of the total number of collected nodes remains controversial. Our aim was to examine the impact of the metastatic lymph node ratio (LNR) on the survival of patients with Dukes C colorectal cancer. METHODS:All ...

journal_title：International journal of colorectal disease

authors： Thomas M,Biswas S,Mohamed F,Chandrakumaran K,Jha M,Wilson R

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Since its introduction, stapled hemorrhoidopexy (SHP), the so-called Longo procedure, became a widely accepted treatment option for prolapsing hemorrhoids. Nevertheless, from the early years, concerns grew about the early functional results and potential recurrences. In order to evaluate of SHP with special res...

journal_title：International journal of colorectal disease

authors： Voigtsberger A,Popovicova L,Bauer G,Werner K,Weitschat-Benser T,Petersen S

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Lynch syndrome (LS) is associated with a high risk of colorectal cancer (CRC). The aim of this study was to assess the cumulative risk for the development of colorectal adenomas or carcinomas in a LS CRC surveillance program and to audit the quality of the endoscopic procedures. METHODS:We evaluated 147 asympt...

journal_title：International journal of colorectal disease

authors： Vale Rodrigues R,Claro I,Lage P,Rosa I,Ferreira S,Pereira da Silva J,Dias Pereira A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:The prevalence of colorectal cancer in the elderly is increasing and, therefore, surgical interventions with a risk of potential complications are more frequently performed. This study investigated the role of low skeletal muscle mass (sarcopenia), muscle quality, and the sarcopenic obesity as prognostic fac...

journal_title：International journal of colorectal disease

authors： Boer BC,de Graaff F,Brusse-Keizer M,Bouman DE,Slump CH,Slee-Valentijn M,Klaase JM

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:In rectal cancer, prediction of tumor response and pathological complete response (pCR) to neoadjuvant treatment could contribute to refine selection of patients who might benefit from a delayed- or no-surgery approach. The aim of this study was to explore the association of clinical and molecular characteri...

journal_title：International journal of colorectal disease

authors： Alwers E,Jansen L,Kather J,Amitay E,Bläker H,Kloor M,Tagscherer KE,Roth W,Herpel E,Chang-Claude J,Brenner H,Hoffmeister M

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Neoadjuvant chemoradiation (nCRT) followed by curative surgery has gained acceptance as the therapy of choice in locally advanced rectal cancer. This prospective study evaluates the effect of nCRT on postoperative anorectal function and continence. PATIENTS AND METHODS:Group A consisted of 12 patie...

journal_title：International journal of colorectal disease

authors： Pietsch AP,Fietkau R,Klautke G,Foitzik T,Klar E

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. METHODS:Microsatellite status was identified by genotyping. ...

journal_title：International journal of colorectal disease

authors： Lin CC,Lai YL,Lin TC,Chen WS,Jiang JK,Yang SH,Wang HS,Lan YT,Liang WY,Hsu HM,Lin JK,Chang SC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Perianal fistulising Crohn's disease (PFCD) affects a third of Crohn's disease patients and represents a disabling phenotype with poor outcome. The anti-tumour necrosis factor alpha (TNF) therapies have been shown to maintain clinical remission in a third of patients after 1 year of treatment. Maintenance th...

journal_title：International journal of colorectal disease

authors： Adegbola SO,Sahnan K,Tozer PJ,Phillips RK,Faiz OD,Warusavitarne J,Hart A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The functional outcome and quality of life after sphincter-saving operations for ulcerative colitis have not been previously assessed in Indian patients whose dietary habits and socio-cultural practices differ considerably from those in western countries. PATIENTS AND METHODS:Between 1996 and 2002, we perfo...

journal_title：International journal of colorectal disease

authors： Somashekar U,Gupta S,Soin A,Nundy S

更新日期：2010-08-01 00:00:00

abstract：AIMS:This study assesses the value of endorectal ultrasound (ERUS)-directed biopsy in detecting local recurrence of rectal cancer. METHODS:We reviewed the records of patients undergoing ERUS by a single surgeon for surveillance after treatment of rectal adenocarcinoma. Lesions suggestive of local recurrence underwent ...

journal_title：International journal of colorectal disease

authors： Morken JJ,Baxter NN,Madoff RD,Finne CO 3rd

更新日期：2006-04-01 00:00:00

abstract：:Epidemiological studies provide strong evidence to confirm the correlation between cigarette smoking and inflammatory bowel diseases. This relationship is proved to be positive in Crohn's disease and negative in ulcerative colitis. What in smoking alters the course of inflammatory bowel diseases is still a mystery. Di...

journal_title：International journal of colorectal disease

authors： El-Tawil AM

更新日期：2010-06-01 00:00:00

abstract：:Intestinal lymphangiectasia is a rare disorder, usually presenting with protein-losing enteropathy leading to oedema and ascites. We describe a case that presented as an acute surgical emergency with pain and a mass in the right iliac fossa, which was successfully treated by resection of the involved segment of ileum....

journal_title：International journal of colorectal disease

authors： Jameson JS,Boyle JR,Jones L,Rees Y,Kelly MJ

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Emergency right hemicolectomy has been associated with dismal outcome. But, data in Asians is lacking as pathologies that require emergency right hemicolectomy may differ from that in the Western population. The aims of our study were to review our institution's experience with emergency right hemicolectom...

journal_title：International journal of colorectal disease

authors： Tan KK,Liu JZ,Yeow Y,Gunasekaran S,Tan JJ

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Conventional haemorrhoidectomy (CH) is well known to cause significant post-operative pain and delayed return to daily activities. Both surgical wounds and sphincterial apparatus spasms are likely responsible for the pain. In this study, we evaluated the role of glyceryl trinitrate ointment (GTN) in reduci...

journal_title：International journal of colorectal disease

authors： Franceschilli L,D'Ugo S,de Luca E,Cadeddu F,Milito G,di Lorenzo N,Gaspari AL,Sileri P

更新日期：2013-03-01 00:00:00

abstract：:With the introduction of total mesorectal excision (TME) for treatment of rectal cancer, the prognosis of patients with rectal cancer is improved. With this better prognosis, there is a growing awareness about the quality of life of patients after rectal carcinoma. Laparoscopic total mesorectal excision (LTME) for rec...

journal_title：International journal of colorectal disease

authors： Breukink SO,Pierie JP,Hoff C,Wiggers T,Meijerink WJ

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Constipation is frequently seen in patients with mental retardation (MR). Its pathophysiology is poorly understood. Measurement of colon transit time (CTT) differentiates between retentive and non-retentive constipation. AIM:To determine total and segmental CTT in MR patients compared to healthy controls....

journal_title：International journal of colorectal disease

authors： Vande Velde S,Van Biervliet S,Van Goethem G,De Looze D,Van Winckel M

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:A cohort study was carried out to analyse quality indicators in the diagnosis and treatment of rectal carcinoma. METHODS:A total of 2,470 patients with rectal carcinoma treated between 1985 and 2007 at the Department of Surgery, University of Erlangen, were analysed and compared within four time intervals. RE...

journal_title：International journal of colorectal disease

authors： Merkel S,Klossek D,Göhl J,Papadopoulos T,Hohenberger W,Hermanek P

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:We evaluated the current practice of ultra-low anterior resection (uLAR) in patients with lower rectal cancer and compared uLARs using mostly transabdominal approach with or without intersphincteric resection (ISR). METHODS:A total of 624 consecutive lower rectal cancer patients undergoing curative uLAR were p...

journal_title：International journal of colorectal disease

authors： Kim JC,Yu CS,Lim SB,Kim CW,Park IJ,Yoon YS

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:The assessment of bowel habit is important in the management of patients with colorectal disease. There is not an ideal and practical bowel habit scoring system. The current scores have been designed only for a subclass of patients having a particular disorder. Furthemore, they are complex and time consuming. W...

journal_title：International journal of colorectal disease

authors： Zinicola R,Cracco N,Totaro A,Dalla Valle R,Pedrazzi G

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:The ileal pouch-anal anastomosis (IPAA) has become a standard procedure for patients with ulcerative colitis requiring surgical intervention. The technique has greatly improved and, since 1990, all patients at Huddinge University Hospital have been operated on with the double stapled technique. Pelvic seps...

journal_title：International journal of colorectal disease

authors： Hallberg H,Ståhlberg D,Akerlund JE

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:Some recent studies have suggested that fluorescence angiography with indocyanine green (ICG) might be useful for preventing anastomotic leakage (AL) after laparoscopic colorectal surgery. However, its efficacy has not been proven. We evaluated whether intraoperative ICG fluorescence angiography could decrease ...

journal_title：International journal of colorectal disease

authors： Ishii M,Hamabe A,Okita K,Nishidate T,Okuya K,Usui A,Akizuki E,Satoyoshi T,Takemasa I

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Laparoscopic rectal surgery in obese patients is technically challenging. The technological advantages of robotic instruments can help overcome some of those challenges, but whether this translates to superior short-term outcomes is largely unknown. The aim of this study is to compare the short-term surgical ou...

journal_title：International journal of colorectal disease

authors： Panteleimonitis S,Pickering O,Abbas H,Harper M,Kandala N,Figueiredo N,Qureshi T,Parvaiz A

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this debilitating state has not been established. Chronic pain is one of the most important factors decreasing the quality of life in IBD course. Concurrently, management of pa...

journal_title：International journal of colorectal disease

authors： Zielińska A,Sałaga M,Włodarczyk M,Fichna J

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Adenocarcinoma of an ileostomy is rare with less than 50 reported cases in the literature. Ileostomy adenocarcinoma in Crohn's disease is even more rare, with only 4 reported cases. We present a case of ileostomy adenocarcinoma with lymph node metastasis occurring 51 years after proctocolectomy and Brooke ileos...

journal_title：International journal of colorectal disease

authors： Yousaf A,Beatty C,Zinn Z,Cassim R,Gayam S

更新日期：2020-05-01 00:00:00

abstract：:We assessed the reliability of anorectal angle (ARA) measurement as an index of fecal incontinence. The "posterior" ARA was measured at rest, squeezing, and straining in 69 continent and 82 incontinent subjects all complaining of various evacuation dysfunctions. The two groups were homogeneous with regard to sex distr...

journal_title：International journal of colorectal disease

authors： Piloni V,Fioravanti P,Spazzafumo L,Rossi B

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:Although some studies have reported differences in clinicopathological features between left- and right-sided advanced colorectal cancer (CRC), there are few reports regarding early-stage disease. In this study, we aimed to compare the clinicopathological features of left- and right-sided T1 CRC. METHODS:Subje...

journal_title：International journal of colorectal disease

authors： Mochizuki K,Kudo SE,Ichimasa K,Kouyama Y,Matsudaira S,Takashina Y,Maeda Y,Ishigaki T,Nakamura H,Toyoshima N,Mori Y,Misawa M,Ogata N,Kudo T,Hayashi T,Wakamura K,Sawada N,Ishida F,Miyachi H

更新日期：2020-10-01 00:00:00

abstract：:Little is known about the local influence of pneumoperitoneum on components of the peritoneal immune defense mechanisms. We investigated CD25, CD4, CD8 expression and CD4/CD8 ratio of systemic and peritoneal T lymphocytes in a rat model. Fifty male Sprague Dawley rats underwent laparotomy, CO2 pneumoperitoneum, helium...

journal_title：International journal of colorectal disease

authors： Gutt CN,Hollander D,Brier CH,Kim ZG,Lorenz M

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:Our study is the first meta-analysis to compare total mesorectal excision (TME) plus lateral lymph node dissection (LLND) with TME on rectal cancer patients regarding outcomes including overall survival, disease-free survival, local recurrence, complications, urinary dysfunction, and sexual dysfunction. METH...

journal_title：International journal of colorectal disease

authors： Wang X,Qiu A,Liu X,Shi Y

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Published multigene classifiers suggesting outcome prediction for patients with stage UICC II colon cancer have not been translated into a clinical application so far. Therefore, we aimed at validating own and published gene expression signatures employing methods which enable their reconstruction in routine di...

journal_title：International journal of colorectal disease

authors： Gröne J,Lenze D,Jurinovic V,Hummel M,Seidel H,Leder G,Beckmann G,Sommer A,Grützmann R,Pilarsky C,Mansmann U,Buhr HJ,Stein H,Hummel M

更新日期：2011-07-01 00:00:00