Focus on current and future management possibilities in inflammatory bowel disease-related chronic pain.


INTRODUCTION:Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this debilitating state has not been established. Chronic pain is one of the most important factors decreasing the quality of life in IBD course. Concurrently, management of pain is the most challenging issue encountered by clinicians in IBD treatment. AREAS COVERED:This review focuses on pathophysiology of inflammatory bowel disease-caused visceral pain and explores currently available approaches to its management. We also covered recent pharmacological developments in the field. CONCLUSIONS:Pain-related disability has major effects on quality of life and on functional and social outcomes in IBD patients. Currently, there is no one standardized method of managing chronic visceral pain in IBD. Therefore, future development, focusing primarily on alleviating the pain, but also on reducing inflammation, is essential.


Int J Colorectal Dis


Zielińska A,Sałaga M,Włodarczyk M,Fichna J




Has Abstract


2019-02-01 00:00:00














  • Metastatic lymph node ratio is a more precise predictor of prognosis than number of lymph node metastases in stage III colon cancer.

    abstract:OBJECTIVE:The objective of this study is to assess the value of metastatic lymph node ratio (LNR) in predicting disease-free survival (DFS) in patients with stage III adenocarcinoma of the colon. MATERIALS AND METHODS:From 1995 to 2003 inclusively, a total of 624 patients featuring stage III adenocarcinoma of the colo...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Chin CC,Wang JY,Yeh CY,Kuo YH,Huang WS,Yeh CH

    更新日期:2009-11-01 00:00:00

  • Meta-analysis and trial sequential analysis of robotic versus laparoscopic total mesorectal excision in management of rectal cancer.

    abstract:BACKGROUND:We aimed to evaluate comparative outcomes of robotic and laparoscopic total mesorectal excision (TME) in patients with rectal cancer. METHODS:We systematically searched electronic data sources with application of combination of free text and controlled vocabulary search adapted to thesaurus headings, search...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审


    authors: Eltair M,Hajibandeh S,Hajibandeh S,Nuno A,Abdullah KH,Alkaili-Alyamani A,Aslam MI,Sinha A,Agarwal T

    更新日期:2020-08-01 00:00:00

  • Topic infliximab injection for refractory rectal stenosis in Crohn's disease: long-term follow-up in two patients.

    abstract:PURPOSE:TNF blockers are approved for intravenous or subcutaneous systemic therapy of many chronic inflammatory diseases. As it is not possible to achieve a sufficient local clinical improvement through systemic therapy in every patient, diverse approaches of topical therapy using TNF blockers have been investigated in...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Teich N,Wallstabe I,Schiefke I

    更新日期:2017-09-01 00:00:00

  • Rectal endosonography for the visualisation of the anastomosis after anterior resection and its relevance to local recurrence.

    abstract::Rectal endosonography can be used to detect and localise recurrent rectal carcinoma. Distal and proximal to a rectal anastomosis the separate layers of the bowel wall as seen by rectal endosonography are well defined but at the precise level of the anastomosis separation of the layers is lost and they appear to merge....

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Charnley RM,Heywood MF,Hardcastle JD

    更新日期:1990-08-01 00:00:00

  • The Two-Week Referral System for colorectal cancer--not fit for purpose.

    abstract:PURPOSE:The UK government target expects all suspected colorectal cancer (CRC) patients to be seen within the Two-Week Referral (TWR) system made by general practitioners. These guidelines originally derived from only level 5 evidence. However, this has significant impact on the workload for colorectal surgeons. The ai...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Padwick RT,Bajwa AA,Shaw A,Leung E,Francombe J,Stellakis ML

    更新日期:2013-11-01 00:00:00

  • The effect of a diverting stoma on morbidity and risk of permanent stoma following anastomotic leakage after low anterior resection for rectal cancer: a nationwide cohort study.

    abstract:BACKGROUND:Diverting stomata (DS) have been shown to mitigate the clinical impact of anastomotic leakage (AL) but not without complications, and their routine use remains a matter of international debate. The objective of this study was to examine the association between stomata and the clinical consequences of AL. ME...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Schlesinger NH,Smith H

    更新日期:2020-10-01 00:00:00

  • The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT.

    abstract:BACKGROUND:To evaluate the value of positron emission tomography using fluorodeoxyglucose and computer tomography scan (FDG-PET/CT) for prediction of histopathological response of preoperative radiochemotherapy (RCTX) in patients with rectal carcinoma. METHODS:Thirty patients with uT3 rectal carcinoma were examined by...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章


    authors: Rosenberg R,Herrmann K,Gertler R,Künzli B,Essler M,Lordick F,Becker K,Schuster T,Geinitz H,Maak M,Schwaiger M,Siewert JR,Krause B

    更新日期:2009-02-01 00:00:00

  • Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells.

    abstract:BACKGROUND AND AIMS:Photodynamic therapy (PDT) is a new treatment modality for early esophageal neoplasia. With two absorption maxima in the visible light range (550 and 588 nm) hypericin is a very promising photosensitizer for PDT with incoherent light sources. We studied the effects of photosensitizing hypericin in b...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Höpfner M,Maaser K,Theiss A,Lenz M,Sutter AP,Kashtan H,von Lampe B,Riecken EO,Zeitz M,Scherübl H

    更新日期:2003-05-01 00:00:00

  • Placement of SurgiWrap® adhesion barrier film around the protective loop stoma after laparoscopic colorectal cancer surgery may reduce the peristomal adhesion severity and facilitate the closure.

    abstract:PURPOSE:A temporary loop stoma is often created after laparoscopic colorectal cancer surgery. Peristomal adhesions may make stoma closure into a complicated operation. We demonstrated how to place the SurgiWrap® adhesion barrier film and evaluated the peristomal adhesion severity and feasibility of stoma closure. METH...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Hsu CW,Chang MC,Wang JH,Wu CC,Chen YH

    更新日期:2019-03-01 00:00:00

  • Ultrasonic endoluminal examination in the follow-up of colorectal cancer. Initial experience and results.

    abstract::We have been using endoluminal ultrasonography since 1988 as part of the follow-up procedure after colorectal surgery. A total of 106 patients with anterior resection of the rectum or the sigmoid colon were involved in 1988. The follow-up period for these patients ranged from 1 to 56 months after surgery (23.1 +/- 15....

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Dresing K,Stock W

    更新日期:1990-12-01 00:00:00

  • Inclusion of cytological features in tumor grading improves prognostic stratification of patients with colorectal cancer.

    abstract:PURPOSE:Tumor grade is a traditional prognostic parameter in colorectal cancer. Remarkably, however, there is still no generally accepted consensus how to perform tumor grading. In this study, we systematically compared the prognostic value of traditional grading based upon histological features, that is, gland formati...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Resch A,Harbaum L,Pollheimer MJ,Kornprat P,Lindtner RA,Langner C

    更新日期:2016-03-01 00:00:00

  • Role of 0.4% glyceryl trinitrate ointment after haemorrhoidectomy: results of a prospective randomised study.

    abstract:INTRODUCTION:Conventional haemorrhoidectomy (CH) is well known to cause significant post-operative pain and delayed return to daily activities. Both surgical wounds and sphincterial apparatus spasms are likely responsible for the pain. In this study, we evaluated the role of glyceryl trinitrate ointment (GTN) in reduci...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,随机对照试验


    authors: Franceschilli L,D'Ugo S,de Luca E,Cadeddu F,Milito G,di Lorenzo N,Gaspari AL,Sileri P

    更新日期:2013-03-01 00:00:00

  • Characteristic findings on defecography according to reconstruction method and defecatory disorder following sphincter-saving surgery for rectal cancer.

    abstract:BACKGROUND AND AIMS:This study used postoperative defecography to characterize morphological features of defecatory disorders in patients following rectal resection. We also evaluated differences in dynamic defecatory condition depending on reconstruction methods for sphincter-saving surgery. MATERIALS AND METHODS:Sub...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Morihiro M,Koda K,Seike K,Miyauchi H,Miyazaki M

    更新日期:2008-09-01 00:00:00

  • Intensive surveillance following curative treatment of colorectal cancer allows effective treatment of recurrence even if limited to 4 years.

    abstract:BACKGROUND:Current evidence suggests a survival benefit to post-operative surveillance following curative colorectal cancer resection; however, there is still no consensus on the optimal duration and form. OBJECTIVES:The objective is to prospectively audit outcomes of an intensive colorectal cancer follow-up scheme fo...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Adams K,Higgins L,Beazley S,Papagrigoriadis S

    更新日期:2015-12-01 00:00:00

  • Malignant recurrence and distal metastasis after complete local resection of colorectal "high-grade intraepithelial neoplasia": incidence and risk factors.

    abstract:BACKGROUND:Colorectal high-grade intraepithelial neoplasia is defined as a high-grade neoplastic lesion with no invasion of submucosa. Because pathological evaluation has inevitable sampling errors, invasive cancer may be underdiagnosed as high-grade intraepithelial neoplasia by regarding submucosa invasion as an indis...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Wei XB,Xin L,Hao J

    更新日期:2014-12-01 00:00:00

  • Risk of lymph node metastasis after endoscopic treatment for rectal NETs 10 mm or less.

    abstract:PURPOSE:For rectal neuroendocrine tumors (NETs) ≤ 10 mm, endoscopic resection is a standard treatment. However, there is no consensus whether additional surgery should be performed for patients at risk of lymph node metastasis (LNM) after endoscopic resection. The purpose of this study was to analyze the results of end...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Inada Y,Yoshida N,Fukumoto K,Hirose R,Inoue K,Dohi O,Murakami T,Ogiso K,Tomie A,Kugai M,Yoriki H,Inagaki Y,Hasegawa D,Okuda K,Okuda T,Morinaga Y,Kishimoto M,Itoh Y

    更新日期:2021-01-02 00:00:00

  • Abdominal rectopexy for complete rectal prolapse: preliminary results of a new technique.

    abstract:PURPOSE:Although the technique for the surgical repair of rectal prolapse has advanced over the years, no ideal procedure has been found. We aim to test a new surgical procedure for abdominal rectopexy that uses the greater omentum to support the rectum below the rectopexy, to reconstruct the anorectal angle and dispen...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Di Giorgio A,Biacchi D,Sibio S,Accarpio F,Sinibaldi G,Petrella L,Cappiello FR,Sammartino P

    更新日期:2005-03-01 00:00:00

  • External coating of colonic anastomoses: a systematic review.

    abstract:PURPOSE:Colon anastomotic leakage remains both a frequent and serious complication in gastrointestinal surgery. External coating of colonic anastomoses has been proposed as a means to lower the rate of this complication. The aim of this review was to evaluate existing studies on external coating of colonic anastomoses....

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审


    authors: Pommergaard HC,Achiam MP,Rosenberg J

    更新日期:2012-10-01 00:00:00

  • Endorectal ultrasound-directed biopsy: a useful technique to detect local recurrence of rectal cancer.

    abstract:AIMS:This study assesses the value of endorectal ultrasound (ERUS)-directed biopsy in detecting local recurrence of rectal cancer. METHODS:We reviewed the records of patients undergoing ERUS by a single surgeon for surveillance after treatment of rectal adenocarcinoma. Lesions suggestive of local recurrence underwent ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Morken JJ,Baxter NN,Madoff RD,Finne CO 3rd

    更新日期:2006-04-01 00:00:00

  • Development of a clinical model to predict secondary non-response of infliximab treatment in Crohn's disease.

    abstract:PURPOSE:Secondary non-response to infliximab (IFX) in patients with Crohn's disease (CD) is so common that prediction of non-response is required to adopt the optimal therapy for an individual patient. METHODS:The clinical model was constructed in a training cohort. Clinical features, serological parameters, and genet...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Xu L,Shen J,Zheng Q

    更新日期:2020-11-01 00:00:00

  • Effect of neoadjuvant chemoradiation on postoperative fecal continence and anal sphincter function in rectal cancer patients.

    abstract:BACKGROUND AND AIMS:Neoadjuvant chemoradiation (nCRT) followed by curative surgery has gained acceptance as the therapy of choice in locally advanced rectal cancer. This prospective study evaluates the effect of nCRT on postoperative anorectal function and continence. PATIENTS AND METHODS:Group A consisted of 12 patie...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章


    authors: Pietsch AP,Fietkau R,Klautke G,Foitzik T,Klar E

    更新日期:2007-11-01 00:00:00

  • Stapled hemorrhoidopexy: functional results, recurrence rate, and prognostic factors in a single center analysis.

    abstract:PURPOSE:Since its introduction, stapled hemorrhoidopexy (SHP), the so-called Longo procedure, became a widely accepted treatment option for prolapsing hemorrhoids. Nevertheless, from the early years, concerns grew about the early functional results and potential recurrences. In order to evaluate of SHP with special res...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Voigtsberger A,Popovicova L,Bauer G,Werner K,Weitschat-Benser T,Petersen S

    更新日期:2016-01-01 00:00:00

  • Effect of faecal occult blood testing on colorectal cancer mortality in the surveillance of subjects at moderate risk of colorectal neoplasia: a case-control study.

    abstract::Colonoscopy is the established method of surveillance of subjects at high risk of developing colorectal neoplasia. Its role in the surveillance of a population at moderate risk is less clear, however, as the procedure is expensive, time consuming and occasionally hazardous. The aim of this study was to estimate by cas...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Lamah M,Norris J,Caffarey SM,Broughton M,Marks CG

    更新日期:2001-09-01 00:00:00

  • Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different.

    abstract:BACKGROUND AND AIMS:We previously reported that the sole clinicopathological parameters of carcinomas diagnosed in a single institution in 1975 differed from those in patients diagnosed in 1995. The findings might be compatible with the loss of importance of the microsatellite instability of the carcinogenic pathway. ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Rudzki Z,Zazula M,Okoń K,Stachura J

    更新日期:2002-05-01 00:00:00

  • Clinical results after restorative proctocolectomy without diverting ileostomy for ulcerative colitis.

    abstract:BACKGROUND AND AIMS:This study evaluated the postoperative complications and clinical results of restorative proctocolectomy without diverting ileostomy for ulcerative colitis. PATIENTS AND METHODS:One hundred selected patients had a hand-sewn ileal J-pouch anal anastomosis with mucosectomy using an ultrasonically act...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Ikeuchi H,Shoji Y,Kusunoki M,Yanagi H,Noda M,Yamamura T

    更新日期:2004-05-01 00:00:00

  • Mesenteric fibromatosis.

    abstract::Mesenteric fibromatosis is a rare, locally invasive, non-metastasizing type of intra-abdominal fibromatoses with a very high rate of recurrence. Because of rarity, these tumors pose a diagnostic and therapeutic challenge. These tumors may remain asymptomatic, but commonly present as a painless mass. There are no clear...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审


    authors: Chaudhary P

    更新日期:2014-12-01 00:00:00

  • Analysis of rectal dynamic and static compliances in patients with irritable bowel syndrome.

    abstract:AIMS:Our aim was to investigate whether the dynamic and static compliances differ between patients with irritable bowel syndrome (IBS) and normal subjects. MATERIALS AND METHODS:Fifty-five IBS patients (age range 20-65 years, mean age 39.0 years, 28 women and 27 men; 36 diarrhea-predominant IBS (IBS-D) patients and 19...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Park JH,Baek YH,Park DI,Kim HJ,Cho YK,Sohn CI,Jeon WK,Kim BI,Rhee PL

    更新日期:2008-07-01 00:00:00

  • Faecal occult blood screening of first degree relatives of patients with colorectal cancer.

    abstract::A full first-degree family history was taken from 161 patients with colorectal cancer (Group 1) and from a group of 203 subjects previously investigated and found to have no colorectal neoplasia (Group 2). Twenty-six (16%) of patients in Group 1 compared with 23 (11%) in Group 2 had at least 1 first-degree relative wi...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Armitage NC,Farrands PA,Mangham CM,Hardcastle JD

    更新日期:1986-10-01 00:00:00

  • Nodal staging in rectal cancer: why is restaging after chemoradiation more accurate than primary nodal staging?

    abstract:PURPOSE:This study aims to explore the influence of chemoradiation treatment (CRT) on rectal cancer nodes and to generate hypotheses why nodal restaging post-CRT is more accurate than at primary staging. METHODS:Thirty-nine patients with locally advanced rectal cancer underwent MRI pre- and post-CRT. All visible mesor...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Heijnen LA,Maas M,Beets-Tan RG,Berkhof M,Lambregts DM,Nelemans PJ,Riedl R,Beets GL

    更新日期:2016-06-01 00:00:00

  • The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells.

    abstract:INTRODUCTION:Matrix metalloproteinases (MMPs) have repeatedly been shown to play a very active role in extracellular matrix degradation associated with tumor invasion and metastasis. Tissue inhibitors of MMPs (TIMPs) are well-known for their ability to inhibit MMP activity thereby inhibiting malignant progression. Inos...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Kapral M,Wawszczyk J,Jurzak M,Hollek A,Węglarz L

    更新日期:2012-11-01 00:00:00