Abstract：
PURPOSE:There is strong evidence supporting the importance of the volume-outcome relationship with respect to lung and pancreatic cancers. This relationship for rectal cancer surgery however remains unclear. We review the currently available literature to assess the evidence base for volume outcome in relation to rectal cancer surgery. METHODS:We analysed the Medline "PubMed" online database using the keyword search parameters of "rectal cancer", "hospital volume or caseload", "surgeon volume or caseload", "outcomes", "mortality", "approach", "local recurrence" and "morbidity" for the time period 1997-2009. Five hundred twenty-six generic articles were identified. Articles that were not specific for, or separately identified, rectal cancer surgery in their individual analysis were excluded. Eighteen articles remained for review. We assessed short-term morbidity and long-term outcomes such as sphincter preservation, mortality and local recurrence rates. RESULTS:Considerable variance was noted in the definition of high volume and low volume. Postoperative length of stay was lower and sphincter-preserving surgery was more commonly performed in high-volume hospitals and by high-volume surgeons. Surgeon specialisation was an important factor influencing sphincter preservation, survival and local recurrence rates. Volume was found to have no negative relationship with mortality and a positive one with local recurrence. Interestingly, there was no association found between hospital or surgeon caseload and postoperative morbidity. CONCLUSION:There is a paucity of evidence in the literature regarding the volume-outcome relationship with regard to rectal cancer surgery. High-volume institutions yielded shorter lengths of stay. However, the key finding was that high-volume surgeons that specialised in colorectal surgery yielded objectively improved outcomes for patients with rectal cancer.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Nugent E,Neary Pdoi
10.1007/s00384-010-1019-1subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1389-96issue
12eissn
0179-1958issn
1432-1262journal_volume
25pub_type
杂志文章,评审abstract：PURPOSE:The main operative method in familial adenomatous polyposis (FAP) patients is restorative proctocolectomy with "J"-shaped pouch and temporary loop ileostomy. The aim of the study was the analysis of the frequency of the dysplasia and inflammation in the intestinal pouch and prognosis of the clinical course in F...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-011-1241-5
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Nicotine is of therapeutic value in ulcerative colitis, but its administration is connected with adverse events. Nicotine derivatives are currently being tested to maintain the therapeutic effects and minimize adverse events. TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to dete...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-006-0135-4
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND AND AIM:Sessile serrated adenoma/polyps (SSAPs) are suspected to have a high malignant potential, although few reports have evaluated the incidence of carcinomas derived from SSAPs using the new classification for serrated polyps (SPs). The aim of study was to compare the frequency of cancer coexisting with ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2416-2
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND AND AIMS:As integral membrane proteins, claudins form tight junctions together with occludin. Several claudins were shown to be up-regulated in various cancer types. We performed an expression analysis of genes encoding tight junction proteins to display differential gene expression on RNA and protein level ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-006-0197-3
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:To evaluate the value of positron emission tomography using fluorodeoxyglucose and computer tomography scan (FDG-PET/CT) for prediction of histopathological response of preoperative radiochemotherapy (RCTX) in patients with rectal carcinoma. METHODS:Thirty patients with uT3 rectal carcinoma were examined by...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
doi：10.1007/s00384-008-0616-8
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:Tumor grade is a traditional prognostic parameter in colorectal cancer. Remarkably, however, there is still no generally accepted consensus how to perform tumor grading. In this study, we systematically compared the prognostic value of traditional grading based upon histological features, that is, gland formati...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2495-0
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:TNF blockers are approved for intravenous or subcutaneous systemic therapy of many chronic inflammatory diseases. As it is not possible to achieve a sufficient local clinical improvement through systemic therapy in every patient, diverse approaches of topical therapy using TNF blockers have been investigated in...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-017-2860-2
更新日期：2017-09-01 00:00:00
abstract：:Between 1979 and 1989, 169 patients had a curative operation for right sided colonic cancer. A retrospective analysis of the incidence and degree of lymph node metastasis was performed in all and survival rate was determined in 144 patients who could be followed over a period of 5 years or more. In all patients, disse...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840050104
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:Secondary non-response to infliximab (IFX) in patients with Crohn's disease (CD) is so common that prediction of non-response is required to adopt the optimal therapy for an individual patient. METHODS:The clinical model was constructed in a training cohort. Clinical features, serological parameters, and genet...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03679-8
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND AND AIM:Concurrent definitive treatment of underlying fistulas from infected anal glands at the time when the anorectal abscesses are drained is controversial as this is associated with a higher incidence of faecal incontinence, failure and recurrence. This meta-analysis was conducted to determine the merits...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00384-005-0060-y
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:To analyze the results of abdominoperineal excisions (APE) for locally advanced rectal cancer at our institution before and after the adoption of extralevator abdominoperineal excision (ELAPE) with a special reference to long-term survival. METHODS:A retrospective cohort study conducted in a tertiary referral ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-2977-y
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Extramammary Paget's disease (EMPD) most commonly occurs in the perineal and genital areas of elderly people. The current treatment of choice is adequate surgical excision. MATERIALS AND METHODS:Between 1990 and 2007, 28 patients (27 men and one woman) with EMPD were treated at Asan Medical Center, Seoul, K...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-008-0499-8
更新日期：2008-11-01 00:00:00
abstract：PURPOSE:We evaluated the current practice of ultra-low anterior resection (uLAR) in patients with lower rectal cancer and compared uLARs using mostly transabdominal approach with or without intersphincteric resection (ISR). METHODS:A total of 624 consecutive lower rectal cancer patients undergoing curative uLAR were p...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2303-x
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Genetic variability in obesity-related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease. MATERIALS AND METHODS:A total of 102 patients (aged 68 +/- 10.2 years, 79 men and 23 women) and 101 age-matched (68.1 +/- 5.4 years old) ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-008-0553-6
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:This study was designed to examine the impact of an omentoplasty and its quality on pelviperineal morbidity after abdominoperineal resection (APR) for rectal cancer. METHODS:This was a retrospective single-centre study of consecutive patients undergoing APR for primary or recurrent rectal cancer between 2000 a...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-019-03412-0
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:The prevalence of colorectal cancer in the elderly is increasing and, therefore, surgical interventions with a risk of potential complications are more frequently performed. This study investigated the role of low skeletal muscle mass (sarcopenia), muscle quality, and the sarcopenic obesity as prognostic fac...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2538-1
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:Several studies demonstrate an increased prevalence and concordance of inflammatory bowel disease among the relatives of patients. Other studies suggest that genetic influence is over-estimated. The aims of this study are to evaluate the phenotypic expression and the treatment requirements in familial inflammat...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-017-2791-y
更新日期：2017-08-01 00:00:00
abstract：:Familial adenomatous polyposis (FAP), is a genetic premalignant condition which, if untreated, will ultimately manifest with the development of colorectal carcinoma. It is a disease of young adulthood. Rectal and colonic polyps are seldom seen before 10 years of age. Screening of clinically asymptomatic relatives thus...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00341240
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Neoadjuvant chemoradiation (nCRT) followed by curative surgery has gained acceptance as the therapy of choice in locally advanced rectal cancer. This prospective study evaluates the effect of nCRT on postoperative anorectal function and continence. PATIENTS AND METHODS:Group A consisted of 12 patie...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
doi：10.1007/s00384-007-0322-y
更新日期：2007-11-01 00:00:00
abstract：PURPOSE:Although small rectal carcinoid tumors can be treated using local excision, complete resection can be difficult because tumors are located in the submucosal layer. We evaluate the factors associated with pathologically complete local resection of rectal carcinoid tumors. METHODS:Data were analyzed of 161 patie...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-012-1538-z
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Prior international datasets have demonstrated equivocal results in the rate of surgical procedures for the treatment of Crohn's disease (CD) following the introduction of biologic medications. The first biologic medication licensed for use in the Republic of Ireland (ROI) was infliximab in 1999. The curre...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1698-5
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:This study aims to evaluate pubovisceral muscle and anal sphincter defects in women with previous vaginal delivery and fecal incontinence and to correlate the findings with the severity of symptoms using the combined anorectal and endovaginal 3D ultrasonography with a new ultrasound scoring system. METHODS:Con...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2750-z
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The clinicopathological roles and relationships of hTERT, p21 and p53 proteins have not been studied in depth in colorectal cancer. The aim of the present study is to investigate the clinicopathological roles of expression of hTERT protein expression and its relationship with the expression of p21 and p53 pr...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-008-0455-7
更新日期：2008-06-01 00:00:00
abstract：:Colonoscopy is the established method of surveillance of subjects at high risk of developing colorectal neoplasia. Its role in the surveillance of a population at moderate risk is less clear, however, as the procedure is expensive, time consuming and occasionally hazardous. The aim of this study was to estimate by cas...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840100316
更新日期：2001-09-01 00:00:00
abstract：INTRODUCTION:Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this debilitating state has not been established. Chronic pain is one of the most important factors decreasing the quality of life in IBD course. Concurrently, management of pa...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s00384-018-3218-0
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The functional outcome and quality of life after sphincter-saving operations for ulcerative colitis have not been previously assessed in Indian patients whose dietary habits and socio-cultural practices differ considerably from those in western countries. PATIENTS AND METHODS:Between 1996 and 2002, we perfo...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-010-0974-x
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:Surgical consultation is recommended for all patients with fulminant Clostridioides difficile infection (CDI). If surgery is required, total abdominal colectomy (TAC) is most commonly performed. However, diverting loop ileostomy and colonic lavage have been recently developed as a potential colon-sparing approa...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析
doi：10.1007/s00384-019-03447-3
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:The aim of this study is to evaluate the influence of germline vascular endothelial growth factor (VEGF) gene polymorphisms (VGPs) on the efficacy of the anti-VEGF antibody bevacizumab (Bev) in metastatic colorectal cancer (MCRC) patients. METHODS:Forty MCRC patients eligible for a first-line therapy were enro...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-010-1108-1
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:Sound speed correction (SSC) is a non-invasive modality that quantifies the hardness of neoplasms. The aim of our study was to evaluate the usefulness of SSC for the diagnostic accuracy of colorectal neoplasms and to differentiate the depth of invasion. METHODS:Forty colorectal neoplasms, contributed by 40 pat...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03790-w
更新日期：2020-10-28 00:00:00
abstract：PURPOSE:Resource limitations are a concern in most modern public hospital systems. The aim of this study is to prospectively quantify the total caseload of a tertiary colorectal surgery unit to identify areas of redundancy. METHODS:Data was collected prospectively at all points of clinical care (outpatient clinic, inp...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2556-z
更新日期：2016-06-01 00:00:00
