(E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa.


BACKGROUND:Nicotine is of therapeutic value in ulcerative colitis, but its administration is connected with adverse events. Nicotine derivatives are currently being tested to maintain the therapeutic effects and minimize adverse events. TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to determine the effectiveness of TC-2403-12 in the inhibition of TNF- and lipopolysaccharide (LPS)-induced cell activation. METHODS:Colonic epithelial cells (CEC), monocytes (MM6), granulocytes, and the intestinal epithelial cell line HT-29 were stimulated with TNF and LPS and treated with TC-2403-12. IL-8 secretion in the cell supernatants and NF-kappaB activation were determined by ELISA. Apoptosis was quantified by flow cytometry. RESULTS:In MM6 cells, IL-8 secretion was significantly decreased to 30% of control after TC-2403-12 treatment, with best results after pretreatment for 24 h. This decrease in cell activation was not due to apoptosis and was not mediated by inhibition of NF-kappaB activation. IL-8 production in neutrophils and primary CEC also tended to be decreased after TC-2403-12 treatment. TC-2403-12 had no influence on IL-8 secretion of HT-29 cells. CONCLUSION:TC-2403-12 effectively inhibited TNF- and LPS-induced IL-8 production in different cell types. No toxic effects occurred at the concentrations used. Preincubation of cells with TC-2403-12 showed the best effects.


Int J Colorectal Dis


Spoettl T,Paetzel C,Herfarth H,Bencherif M,Schoelmerich J,Greinwald R,Gatto GJ,Rogler G




Has Abstract


2007-03-01 00:00:00












  • Ambulatory versus conventional laparoscopic appendectomy: a systematic review and meta-analysis.

    abstract:PURPOSE:Ambulatory laparoscopic appendectomy has gained popularity due to the improved understanding of patient selection criteria, the application of enhanced recovery pathways, and the potential for improving healthcare resource utilization. The aim of the review was to compare the morbidity and readmission rates bet...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析


    authors: Trejo-Avila M,Cárdenas-Lailson E,Valenzuela-Salazar C,Herrera-Esquivel J,Moreno-Portillo M

    更新日期:2019-08-01 00:00:00

  • Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different.

    abstract:BACKGROUND AND AIMS:We previously reported that the sole clinicopathological parameters of carcinomas diagnosed in a single institution in 1975 differed from those in patients diagnosed in 1995. The findings might be compatible with the loss of importance of the microsatellite instability of the carcinogenic pathway. ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Rudzki Z,Zazula M,Okoń K,Stachura J

    更新日期:2002-05-01 00:00:00

  • Association between serum bilirubin and mucosal healing among Japanese patients with ulcerative colitis: a cross-sectional study.

    abstract:PURPOSE:Bilirubin is known to have antioxidant effects. Several pieces of evidence regarding association between serum bilirubin and UC exist. Three studies found that serum bilirubin was inversely associated with severity of ulcerative colitis (UC), but no evidence regarding an association between serum bilirubin and ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Shiraishi K,Furukawa S,Yagi S,Hanayama M,Mori K,Ninomiya T,Suzuki S,Ohashi K,Murakami H,Takeshita E,Ikeda Y,Hiasa Y

    更新日期:2021-02-01 00:00:00

  • Treating symptomatic adhesions to the sigmoid colon: colectomy improves quality of life.

    abstract:INTRODUCTION:When severe chronic pelvic pain, constipation, and bloating are due to dense pelvic adhesions fixing the sigmoid loops, patients may be offered the option of sigmoid colectomy. This study examines the effectiveness of colectomy in the treatment of such patients. METHODS:Patients were identified from a sur...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Jarrar A,Church J

    更新日期:2013-10-01 00:00:00

  • Comparable outcomes of the consistent use versus switched use of anti- tumor necrosis factor agents in postoperative recurrent Crohn's disease following ileocolonic resection.

    abstract:PURPOSE:There are no published data or guidelines on whether the same anti-tumor-necrosis factor (TNF) agents used preoperatively or different anti-TNF agents are preferable to treat postoperative recurrence. Our aim was to compare the efficacy of the consistent vs. switched anti-TNF approaches in patients with recurre...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Li Y,Stocchi L,Rui Y,Remzi FH,Shen B

    更新日期:2016-11-01 00:00:00

  • Intensive surveillance following curative treatment of colorectal cancer allows effective treatment of recurrence even if limited to 4 years.

    abstract:BACKGROUND:Current evidence suggests a survival benefit to post-operative surveillance following curative colorectal cancer resection; however, there is still no consensus on the optimal duration and form. OBJECTIVES:The objective is to prospectively audit outcomes of an intensive colorectal cancer follow-up scheme fo...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Adams K,Higgins L,Beazley S,Papagrigoriadis S

    更新日期:2015-12-01 00:00:00

  • Characteristic findings on defecography according to reconstruction method and defecatory disorder following sphincter-saving surgery for rectal cancer.

    abstract:BACKGROUND AND AIMS:This study used postoperative defecography to characterize morphological features of defecatory disorders in patients following rectal resection. We also evaluated differences in dynamic defecatory condition depending on reconstruction methods for sphincter-saving surgery. MATERIALS AND METHODS:Sub...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Morihiro M,Koda K,Seike K,Miyauchi H,Miyazaki M

    更新日期:2008-09-01 00:00:00

  • Total caseload of a colorectal surgical unit: baseline measurement and identification of areas for efficiency gains.

    abstract:PURPOSE:Resource limitations are a concern in most modern public hospital systems. The aim of this study is to prospectively quantify the total caseload of a tertiary colorectal surgery unit to identify areas of redundancy. METHODS:Data was collected prospectively at all points of clinical care (outpatient clinic, inp...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Sammour T,Macleod A,Chittleborough TJ,Chandra R,Shedda SM,Hastie IA,Jones IT,Hayes IP

    更新日期:2016-06-01 00:00:00

  • A systematic review and meta-analysis of adjuvant chemotherapy after neoadjuvant treatment and surgery for rectal cancer.

    abstract:BACKGROUND:Current guidelines support the use of adjuvant chemotherapy (CT) following neoadjuvant chemoradiotherapy (CTRT) and surgery to treat rectal cancer, although clinical trials have provided little evidence that it is effective. We performed a systematic review of published studies to assess whether adjuvant CT ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审


    authors: Petrelli F,Coinu A,Lonati V,Barni S

    更新日期:2015-04-01 00:00:00

  • Conversion during laparoscopic colorectal resections: a complication or a drawback? A systematic review and meta-analysis of short-term outcomes.

    abstract:PURPOSE:Several studies compared the outcomes of laparoscopically completed colorectal resections (LCR) to those requiring conversion to open surgery (COS). However, a comparative analysis between COS patients and patients undergoing planned open surgery (POS) would be useful to clarify if the conversion can be conside...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审


    authors: Giglio MC,Celentano V,Tarquini R,Luglio G,De Palma GD,Bucci L

    更新日期:2015-11-01 00:00:00

  • Anastomotic leak risk in complete responders to neoadjuvant therapy for rectal cancer: a systematic review.

    abstract:PURPOSE:The oncological benefits of achieving a complete pathological response following neoadjuvant chemoradiotherapy for rectal cancer are well defined. How a pathological response affects anastomotic healing or leak rates is not clear. The aim of this systematic review was to compare anastomotic leak rates among pat...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审


    authors: Zaborowski AM,Stakelum A,Winter DC

    更新日期:2021-01-11 00:00:00

  • The Two-Week Referral System for colorectal cancer--not fit for purpose.

    abstract:PURPOSE:The UK government target expects all suspected colorectal cancer (CRC) patients to be seen within the Two-Week Referral (TWR) system made by general practitioners. These guidelines originally derived from only level 5 evidence. However, this has significant impact on the workload for colorectal surgeons. The ai...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Padwick RT,Bajwa AA,Shaw A,Leung E,Francombe J,Stellakis ML

    更新日期:2013-11-01 00:00:00

  • Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports.

    abstract:PURPOSE:Kras mutations are negative predictors of anti-EGFR therapy, occurring in 40% of colorectal carcinomas (CRCs). Point substitutions in codon 12 or 13 are the most frequent mutations in Kras, but multiple mutations (MMs) in other codons can also develop. Few data exist on MMs with regard to their frequency and th...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审


    authors: Macedo MP,Andrade Lde B,Coudry R,Crespo R,Gomes M,Lisboa BC,Aguiar S Jr,Soares FA,Carraro DM,Cunha IW

    更新日期:2011-10-01 00:00:00

  • Rescue therapy with tacrolimus in a patient with toxic megacolon.

    abstract:BACKGROUND:Toxic megacolon is a life-threatening complication most commonly observed in patients with ulcerative colitis or Crohn's disease that is characterized by total or segmental nonobstructive colonic dilatation of at least 6 cm on plain abdominal films associated with systemic toxicity. CASE REPORT:We report an...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Pascu M,Müller AR,Wiedenmann B,Dignass AU

    更新日期:2003-05-01 00:00:00

  • Metastatic lymph node ratio is a more precise predictor of prognosis than number of lymph node metastases in stage III colon cancer.

    abstract:OBJECTIVE:The objective of this study is to assess the value of metastatic lymph node ratio (LNR) in predicting disease-free survival (DFS) in patients with stage III adenocarcinoma of the colon. MATERIALS AND METHODS:From 1995 to 2003 inclusively, a total of 624 patients featuring stage III adenocarcinoma of the colo...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Chin CC,Wang JY,Yeh CY,Kuo YH,Huang WS,Yeh CH

    更新日期:2009-11-01 00:00:00

  • A high lymph node yield in colon cancer is associated with age, tumour stage, tumour sub-site and priority of surgery. Results from a prospective national cohort study.

    abstract:AIM:To determine the relation between patient-related and histopathological factors, as well as the influence of national programs for diagnosing and treatment of colon cancer and a lymph node yield (LNY) ≥ 12. METHOD:An analysis was carried out of the LNY in a nationwide Danish cohort treated by curative resection of...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Lykke J,Jess P,Roikjær O,Danish Colorectal Cancer Group.

    更新日期:2016-07-01 00:00:00

  • Pelvic abscess associated with anastomotic leak in patients with ileal pouch-anal anastomosis (IPAA): transanastomotic or CT-guided drainage?

    abstract:AIM:Evidence is lacking whether an abscess associated with anastomotic leak after an ileal pouch-anal anastomosis (IPAA) should be drained by transanal or CT-guided drainage. Therefore, the aim of this study was to compare outcomes after the two techniques for drainage. METHOD:Patients who underwent IPAA (1984-2009) a...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章


    authors: Kirat HT,Remzi FH,Shen B,Kiran RP

    更新日期:2011-11-01 00:00:00

  • Temperature-controlled radio frequency energy delivery (Secca procedure) for the treatment of fecal incontinence: results of a prospective study.

    abstract:PURPOSE:Fecal incontinence (FI) is a debilitating condition that can be socially and personally incapacitating. A broad range of treatment options, often stepwise, are available, depending on severity. This prospective study reports a large single-centered series of patients who have benefited of temperature-controlled...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章


    authors: Lefebure B,Tuech JJ,Bridoux V,Gallas S,Leroi AM,Denis P,Michot F

    更新日期:2008-10-01 00:00:00

  • Short-term outcomes of laparoscopic surgery for colorectal cancer in the elderly versus non-elderly: a systematic review and meta-analysis.

    abstract:PURPOSE:Laparoscopic surgery for colorectal cancer has spread globally. The usefulness of laparoscopic surgery for elderly patients was initially indicated by comparison with open surgery. However, whether the procedure is safe for elderly as well as non-elderly patients with colorectal cancer remains unclear. METHODS...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析


    authors: Hoshino N,Fukui Y,Hida K,Sakai Y

    更新日期:2019-03-01 00:00:00

  • Total abdominal colectomy vs. restorative total proctocolectomy as the initial approach to medically refractory ulcerative colitis.

    abstract:PURPOSE:There is scant data assessing the consequences of staging restorative proctocolectomy for ulcerative colitis. The aim of the study is to compare outcomes of initial vs. staged restorative proctocolectomy. METHODS:Patients completing restorative proctocolectomy, including ileostomy reversal, during 2006-2012 we...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Gu J,Stocchi L,Ashburn J,Remzi FH

    更新日期:2017-08-01 00:00:00

  • To drain or not to drain in colorectal anastomosis: a meta-analysis.

    abstract:BACKGROUND:Currently, many surgeons place a prophylactic drain in the abdominal or pelvic cavity after colorectal anastomosis as a conventional treatment. However, some trials have demonstrated that this procedure may not be beneficial to the patients. OBJECTIVE:To determine whether prophylactic placement of a drain i...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析


    authors: Zhang HY,Zhao CL,Xie J,Ye YW,Sun JF,Ding ZH,Xu HN,Ding L

    更新日期:2016-05-01 00:00:00

  • An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir.

    abstract::The significance of inflammation of the mucosa of the ileal reservoir after restorative proctocolectomy is not known although in some cases it appears to be associated with symptoms when the condition has been referred to as pouchitis. This investigation has aimed to determined the prevalence of inflammation, to defin...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Moskowitz RL,Shepherd NA,Nicholls RJ

    更新日期:1986-07-01 00:00:00

  • Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells.

    abstract::The mechanisms of the antineoplastic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) still are unknown, but the induction of apoptosis is one of the possible mechanisms. We attempted to demonstrate the role of mitogen-activated protein (MAP) kinases, generally considered to be important mediators of proliferat...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Kim TI,Jin SH,Kim WH,Kang EH,Choi KY,Kim HJ,Shin SK,Kang JK

    更新日期:2001-06-01 00:00:00

  • Synergistical toll-like receptors activated dendritic cells induce antitumor effects against carcinoembryonic antigen-expressing colon cancer.

    abstract:PURPOSE:Dendritic cell (DC)-based cancer vaccine represents a promising immunotherapy against cancer. There has been recent evidence which have suggested that toll-like receptor (TLR) ligands may be critical for DC preparation; this was usually omitted in the past. Our study is designed to investigate if the vaccinatio...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Hong X,Dong T,Hu J,Yi T,Li W,Zhang Z,Lin S,Niu W

    更新日期:2013-01-01 00:00:00

  • Little consensus in either definition or diagnosis of a lower gastro-intestinal anastomotic leak amongst colorectal surgeons.

    abstract:PURPOSE:The purposes of this study were to assess the working definition of a colorectal anastomotic leak among colorectal surgeons and to survey the current approach to investigation and management of a patient with a suspected anastomotic leak. METHODS:Online survey consisting of nine questions regarding the definit...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Adams K,Papagrigoriadis S

    更新日期:2013-07-01 00:00:00

  • Association between increased tumor necrosis factor alpha levels and acquired activated protein C resistance in patients with metastatic colorectal cancer.

    abstract:PURPOSE:The purpose of this study was to investigate the possible association between tumor necrosis factor-α (TNF-α) levels and defects in the activated protein C (APC) system as a determinant of venous thromboembolism (VTE) in metastatic colorectal cancer patients (mCRC) undergoing chemotherapy. METHODS:TNF-α levels...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Ferroni P,Riondino S,Portarena I,Formica V,La Farina F,Martini F,Massimiani G,Palmirotta R,Guadagni F,Roselli M

    更新日期:2012-12-01 00:00:00

  • Effects of the angiogenesis inhibitor angiostatin on the growth of CC531 colon carcinoma cells in vitro and in a laparoscopic animal model of peritoneal carcinomatosis.

    abstract:BACKGROUND:As angiogenesis is one of the key steps in tumor growth, invasion, and metastasis, antiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. We investigated the cytotoxic, anti-adhesive, and anti-invasive effects of angiostatin in vitro and on intraperitoneal tumor growth in a ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Nestler G,Schulz HU,Tautenhahn J,Kuhn R,Krüger S,Lippert H,Pross M

    更新日期:2006-05-01 00:00:00

  • Time-saving polyp detection in colon capsule endoscopy: evaluation of a novel software algorithm.

    abstract:BACKGROUND:Colon capsule endoscopy (CCE) is a reliable method to detect colonic polyps in the well-prepared colon. As CCE evaluation can be time consuming, a new software algorithm might aid in reducing evaluation time. OBJECTIVES:The aim of the study was to evaluate whether it is feasible to reliably detect colon pol...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Hausmann J,Linke JP,Albert JG,Masseli J,Tal A,Kubesch A,Filmann N,Philipper M,Farnbacher M

    更新日期:2019-11-01 00:00:00

  • A comparison of abdominal surgical outcomes between African-American and Caucasian Crohn's patients.

    abstract:BACKGROUND AND OBJECTIVE:Whether race affects the natural history of Crohn's disease is a matter of debate. The aim of the current study was to evaluate the differences in surgical outcomes between African-American (AA) and Caucasian (C) Crohn's patients undergoing surgery at a tertiary care referral center. METHODS:W...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章


    authors: Griglione N,Yarandi S,Srinivasan J,Ahearn T,Dhere T

    更新日期:2014-08-01 00:00:00

  • Meta-analysis: sacral nerve stimulation versus conservative therapy in the treatment of faecal incontinence.

    abstract:AIM:Sacral nerve stimulation (SNS) has recently been used in the management of faecal incontinence (FI). This study compared SNS to conservative management with regards to functional and quality of life outcomes. METHODS:Meta-analysis of studies published between 1995 and 2008 on SNS for FI was performed. Outcomes eva...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析


    authors: Tan E,Ngo NT,Darzi A,Shenouda M,Tekkis PP

    更新日期:2011-03-01 00:00:00