Abstract：
BACKGROUND:Extramammary Paget's disease (EMPD) most commonly occurs in the perineal and genital areas of elderly people. The current treatment of choice is adequate surgical excision. MATERIALS AND METHODS:Between 1990 and 2007, 28 patients (27 men and one woman) with EMPD were treated at Asan Medical Center, Seoul, Korea, by wide local excision (WLE) with a 2- to 3-cm normal skin margin. "Carcinoma in situ" (CIS) was defined as confinement of Paget cells to the epithelium, whereas "invasive carcinoma" was defined as infiltration of Paget cells into more than dermal connective tissue. RESULTS:Of the 28 lesions, 21 (75%) were located in the penoscrotal area. Six (21.4%) patients had associated gastrointestinal neoplasms, three with associated gastrointestinal malignancies and four with synchronous colorectal adenomas, including one with both. Surgical procedures included WLE with primary repair in 13 patients (46.4%), WLE with skin graft in 12 (42.9%), WLE with skin graft and Gracilis muscle transposition in two (7.1%), and combined abdominoperineal resection and distal gastrectomy in one (3.6%). Four patients (14.3%) also underwent inguinal lymph node dissection, with three found to have lymph node metastases. Of 11 patients with invasive carcinoma, three (27.3%) had lymph node metastases, compared with none of 17 patients with CIS. Patients with lymph node metastases showed a significantly lower disease-specific survival rate (P = 0.008). Patients with invasive carcinoma tended to have a lower disease-specific survival rate (P = 0.087). CONCLUSIONS:EMPD in Korea showed an absolute male predominance and an association with gastrointestinal neoplasms. Lymph node metastasis significantly affected, and depth of invasion tended to affect, disease-specific survival rate.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Yoon SN,Park IJ,Kim HC,Yu CS,Lee MW,Koh JK,Kim JW,Park YS,Kim JCdoi
10.1007/s00384-008-0499-8subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1125-30issue
11eissn
0179-1958issn
1432-1262journal_volume
23pub_type
杂志文章abstract：BACKGROUND AND AIMS:We previously reported that the sole clinicopathological parameters of carcinomas diagnosed in a single institution in 1975 differed from those in patients diagnosed in 1995. The findings might be compatible with the loss of importance of the microsatellite instability of the carcinogenic pathway. ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-001-0373-4
更新日期：2002-05-01 00:00:00
abstract：INTRODUCTION:The ileal pouch-anal anastomosis (IPAA) has become a standard procedure for patients with ulcerative colitis requiring surgical intervention. The technique has greatly improved and, since 1990, all patients at Huddinge University Hospital have been operated on with the double stapled technique. Pelvic seps...
journal_title：International journal of colorectal disease
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abstract：PURPOSE:The aim of this pilot study was to compare the performance and safety of the newly developed sodium phosphate (NaP) tablet (with and without laxatives) and polyethylene glycol (PEG), as bowel-cleansing regimens prior to colonoscopy. METHODS:A total of 35 patients were randomized to one of the following three g...
journal_title：International journal of colorectal disease
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更新日期：2009-09-01 00:00:00
abstract：:This study evaluates anorectal function after combined tele- and brachytherapy for anal cancer using manometric measurements and a standardized questionnaire. Eight patients received 44 +/- 3 Gy external beam radiation followed by 20 +/- 4 Gy interstitial brachytherapy with iridium-192. Patients were examined 43 month...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
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abstract：BACKGROUND:Laparoscopic resection for the cure of rectal cancer is still a matter of debate. Laparoscopic approach is more complex and with a long learning curve, which may results in an increase in morbidity and mortality. This study aimed to retrospectively analyze the impact of laparoscopic resection for rectal canc...
journal_title：International journal of colorectal disease
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abstract：PURPOSE:With emphasis of surgical management, the lymph node (LN) status has been advocated to predict prognosis in colon cancer with distant metastatic. Therefore, we tend to compare the prognostic performance of American Joint Committee on Cancer (AJCC) N-staging relative to lymph node ratio (LNR), log odds of metast...
journal_title：International journal of colorectal disease
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journal_title：International journal of colorectal disease
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pub_type： 杂志文章,meta分析,评审
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journal_title：International journal of colorectal disease
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doi：10.1007/s00384-006-0193-7
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journal_title：International journal of colorectal disease
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更新日期：2013-01-01 00:00:00
abstract：PURPOSE:This study aims to evaluate pubovisceral muscle and anal sphincter defects in women with previous vaginal delivery and fecal incontinence and to correlate the findings with the severity of symptoms using the combined anorectal and endovaginal 3D ultrasonography with a new ultrasound scoring system. METHODS:Con...
journal_title：International journal of colorectal disease
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更新日期：2017-04-01 00:00:00
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doi：10.1007/s00384-009-0653-y
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:A cohort study was carried out to analyse quality indicators in the diagnosis and treatment of rectal carcinoma. METHODS:A total of 2,470 patients with rectal carcinoma treated between 1985 and 2007 at the Department of Surgery, University of Erlangen, were analysed and compared within four time intervals. RE...
journal_title：International journal of colorectal disease
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更新日期：2009-08-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,多中心研究
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abstract：:With the introduction of total mesorectal excision (TME) for treatment of rectal cancer, the prognosis of patients with rectal cancer is improved. With this better prognosis, there is a growing awareness about the quality of life of patients after rectal carcinoma. Laparoscopic total mesorectal excision (LTME) for rec...
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journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
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更新日期：2012-10-01 00:00:00
abstract：:The significance of inflammation of the mucosa of the ileal reservoir after restorative proctocolectomy is not known although in some cases it appears to be associated with symptoms when the condition has been referred to as pouchitis. This investigation has aimed to determined the prevalence of inflammation, to defin...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF01648445
更新日期：1986-07-01 00:00:00
abstract：BACKGROUND:Colorectal high-grade intraepithelial neoplasia is defined as a high-grade neoplastic lesion with no invasion of submucosa. Because pathological evaluation has inevitable sampling errors, invasive cancer may be underdiagnosed as high-grade intraepithelial neoplasia by regarding submucosa invasion as an indis...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
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更新日期：2007-11-01 00:00:00
abstract：PURPOSE:Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) compared with other wound therapy techniques. However, the method has occasionally been associated with increased development of intestinal fistulae. The present study measures microvascular blood flow in the...
journal_title：International journal of colorectal disease
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