Abstract：
BACKGROUND AND AIMS:We previously reported that the sole clinicopathological parameters of carcinomas diagnosed in a single institution in 1975 differed from those in patients diagnosed in 1995. The findings might be compatible with the loss of importance of the microsatellite instability of the carcinogenic pathway. MATERIALS AND METHODS:We examined the microsatellite status and selected immunomarkers (Ki-67, p53, BAX) in the archival material from 1975 (n=76) and 1995 (n=105). RESULTS AND CONCLUSION:The distribution of tumors showing no microsatellite instability, low microsatellite instability, and high microsatellite instability in the 2-yearly cohorts was similar (1975: 55.6%, 22.2%, 22.2%; 1995: 60.2%, 20.4%, 19.4%, respectively). The percentage of carcinomas showing microsatellite instability at the APC locus differed significantly (1975: 37.5%; 1995: 21.4%). The typical clinicopathological parameters of carcinomas exhibiting high microsatellite instability were largely shared by the carcinomas demonstrating instability at the APC locus. The carcinomas resected in 1995 more frequently demonstrated high expression of an antiapoptotic protein BAX and a different distribution of their Ki-67 proliferation fraction. The evolution of colorectal carcinoma in Poland also involves qualitative changes, including its genetic background.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Rudzki Z,Zazula M,Okoń K,Stachura Jdoi
10.1007/s00384-001-0373-4subject
Has Abstractpub_date
2002-05-01 00:00:00pages
161-70issue
3eissn
0179-1958issn
1432-1262journal_volume
17pub_type
杂志文章abstract：BACKGROUND:Diverting stomata (DS) have been shown to mitigate the clinical impact of anastomotic leakage (AL) but not without complications, and their routine use remains a matter of international debate. The objective of this study was to examine the association between stomata and the clinical consequences of AL. ME...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03625-8
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Surgical consultation is recommended for all patients with fulminant Clostridioides difficile infection (CDI). If surgery is required, total abdominal colectomy (TAC) is most commonly performed. However, diverting loop ileostomy and colonic lavage have been recently developed as a potential colon-sparing approa...
journal_title：International journal of colorectal disease
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abstract：PURPOSE:The appendix can be a rare cause for chronic right lower quadrant abdominal pain (RLQAP), even though no objective disorder can be determined to the appendix. This condition can be described as chronic appendicitis or (neurogenic) appendicopathy. After careful selection, elective appendectomy is performed in ou...
journal_title：International journal of colorectal disease
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更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Computed tomography (CT) with intravenous contrast is the gold standard for diagnosing diverticulitis. Published results concerning follow-up colonoscopy after an episode of acute diverticulitis to rule out cancer are conflicting. This study aimed to evaluate the risk of underlying colonic malignancy in pati...
journal_title：International journal of colorectal disease
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abstract：BACKGROUND AND AIMS:We evaluated the incidence of dysplasia in the mucosectomy area using resected specimens to determine preoperative risk factors for the occurrence of dysplasia in this area. PATIENTS AND METHODS:We prospectively studied a consecutive series of 137 patients, each of whom underwent a restorative proc...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-006-0178-6
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND AND AIMS:The phenomenon of prostaglandin dependent adaptive cytoprotection has been well established in the stomach and duodenum but not in the colon. This study investigated whether it also occurs in the colon. METHODS:Fisher rats received intracolonic administration (0.5 ml) of saline or acetic acid at lo...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840100332
更新日期：2001-11-01 00:00:00
abstract：:Colorectal surgery is still associated with a significant morbidity and mortality rate, mostly related to suture failure. We have carried out a randomized experimental study in dogs on colonic anastomoses exposed to a number of anastomotic risk situations. A total of 42 dogs was used. They were divided into three stud...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：1992-02-01 00:00:00
abstract：PURPOSE:Several studies compared the outcomes of laparoscopically completed colorectal resections (LCR) to those requiring conversion to open surgery (COS). However, a comparative analysis between COS patients and patients undergoing planned open surgery (POS) would be useful to clarify if the conversion can be conside...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00384-015-2324-5
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this debilitating state has not been established. Chronic pain is one of the most important factors decreasing the quality of life in IBD course. Concurrently, management of pa...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
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abstract：BACKGROUND:There is no general consensus regarding the ideal timing of surgery in patients with refractory ulcerative colitis (UC). Decision-making and timing of restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is influenced by treating physicians and patients themselves. The aim of this study was t...
journal_title：International journal of colorectal disease
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abstract：BACKGROUND:Diverticular disease is a common, chronic inflammatory disease of the bowel. This study investigates the differences in body composition between patients with diverticular disease and those without. METHODS:Appropriate patients were identified using a search of the radiology database. Demographic and diseas...
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更新日期：2018-09-01 00:00:00
abstract：PURPOSE:A temporary loop stoma is often created after laparoscopic colorectal cancer surgery. Peristomal adhesions may make stoma closure into a complicated operation. We demonstrated how to place the SurgiWrap® adhesion barrier film and evaluated the peristomal adhesion severity and feasibility of stoma closure. METH...
journal_title：International journal of colorectal disease
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更新日期：2019-03-01 00:00:00
abstract：PURPOSE:Previous studies have yielded conflicting results on the colonic polyp detection rate with narrow-band imaging (NBI) compared with white-light imaging (WLI). We compared the mean number of colonic polyps detected per patient for NBI versus WLI using a next-generation NBI system (EVIS LUCERA ELITE; Olympus Medic...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2015-07-01 00:00:00
abstract：:440 patients were prospectively enrolled in a randomized, multicenter trial to compare 4 types of manual (84 interrupted end-to-end, 77 continuous end-to-end, 82 interrupted end-to-side, and 91 continuous end-to-side) (polyglycolic derived suture) and 1 type of stapled (106 side-to-side with GIA+TA devices) ileocoloni...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF00341273
更新日期：1993-03-01 00:00:00
abstract：:In the past, it has been noted that experimental tumour cells inoculated into the peritoneal cavity or into the lumen of the bowel will grow at a recently formed colonic anastomosis. However, it has previously been unclear whether the healing process enhances tumour growth or whether the presence of a suture line mere...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF01649697
更新日期：1989-08-01 00:00:00
abstract：PURPOSE:The aim of this prospective randomized clinical study was to evaluate the prevalence of ocular involvement in patients with inflammatory bowel disease (IBD). MATERIALS AND METHODS:We prospectively evaluated 116 patients who went to the gastroenterology clinic with endoscopically proven IBD between December 200...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-007-0275-1
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND AND AIMS:The aim of this study was to determine the detection rate of polyps using zoom chromoendoscopy (ZE) compared with standard video colonoscopy. PATIENTS AND METHODS:End-to-end colonoscopies were performed in 50 patients by two different endoscopists blinded for each other's results. Lesions detected ...
journal_title：International journal of colorectal disease
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doi：10.1007/s00384-005-0052-y
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:Fecal incontinence (FI) is a debilitating condition that can be socially and personally incapacitating. A broad range of treatment options, often stepwise, are available, depending on severity. This prospective study reports a large single-centered series of patients who have benefited of temperature-controlled...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
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abstract：PURPOSE:This study aims to evaluate pubovisceral muscle and anal sphincter defects in women with previous vaginal delivery and fecal incontinence and to correlate the findings with the severity of symptoms using the combined anorectal and endovaginal 3D ultrasonography with a new ultrasound scoring system. METHODS:Con...
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更新日期：2017-04-01 00:00:00
abstract：PURPOSE:Lynch syndrome (LS) is associated with a high risk of colorectal cancer (CRC). The aim of this study was to assess the cumulative risk for the development of colorectal adenomas or carcinomas in a LS CRC surveillance program and to audit the quality of the endoscopic procedures. METHODS:We evaluated 147 asympt...
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更新日期：2021-02-01 00:00:00
abstract：PURPOSE:Acute urinary retention (AUR) is a common postoperative complication in colorectal surgery. In pelvic colorectal operations, the optimal duration for postoperative urinary catheter use is controversial. This systematic review and meta-analysis aims to compare early (POD 1), intermediate (POD 3), and late (POD 5...
journal_title：International journal of colorectal disease
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journal_title：International journal of colorectal disease
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
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更新日期：2011-08-01 00:00:00
abstract：PURPOSE:Anastomotic leakage after low anterior resection for rectal cancer is a critical problem. Many risk factors have been suggested and surgical techniques have improved, but anastomotic leakage remains a major postoperative challenge. This study sought to create a nomogram for precise prediction of anastomotic lea...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
abstract：PURPOSE:The usefulness of restaging by magnetic resonance imaging (MRI) after chemoradiotherapy (CTx/RTx) in patients with locally advanced rectal cancer has not yet been established, mostly due to the difficult differentiation between viable tumor and fibrosis. MRI with dynamic contrast-enhanced (DCE) sequences may be...
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
abstract：INTRODUCTION:The ileal pouch-anal anastomosis (IPAA) has become a standard procedure for patients with ulcerative colitis requiring surgical intervention. The technique has greatly improved and, since 1990, all patients at Huddinge University Hospital have been operated on with the double stapled technique. Pelvic seps...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-004-0717-y
更新日期：2005-11-01 00:00:00
abstract：AIM:Evidence is lacking whether an abscess associated with anastomotic leak after an ileal pouch-anal anastomosis (IPAA) should be drained by transanal or CT-guided drainage. Therefore, the aim of this study was to compare outcomes after the two techniques for drainage. METHOD:Patients who underwent IPAA (1984-2009) a...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
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更新日期：2011-11-01 00:00:00
