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Study of histopathologic parameters to define the prognosis of stage II colon cancer.

Abstract：

PURPOSE:Stage II colon cancer (CC) represents a challenging scenario for the choice of adjuvant chemotherapy; here, histologic factors need to be weighed up to establish the risk of recurrence. Tumor budding (TB) has recently been indicated as a confident predictor of clinical outcome in CC. Likewise, the presence of poorly differentiated clusters (PDCs) in a tumor has been pointed out as a leading criterion of a tumor grading system. Our aim was to evaluate in patients with stage II CC the relationship between these features and clinical outcome. PATIENTS AND METHODS:The study included 174 cases of stage II CC; histopathologic parameters such as TB, PDCs, microsatellite instability (MSI), and CDX2 expression were analyzed. RESULTS:There were 107 (70.9%), 32 (21.2%), and 12 (7.9%) TB scored 1, 2, and 3 respectively; 113 (72.9%), 30 (19.4%), and 12 (7.7%) tumors showed grade 1, 2, and 3 PDCs respectively. A high-MSI was detected in 32 cases (18.4%) while CDX2 was negative in 20 (11.5%) tumor samples. In the whole study population, only the TB was found to be associated with disease-specific survival (P = 0.01). No parameter apart from age (P = 0.04) was a significant prognostic factor for overall survival (P < 0.05). Other commonly reported variables, including tumor size, degree of tumor differentiation, lymphovascular invasion, number of lymph nodes harvested ≥ 12, MSI, and PDCs, were not shown to have significant results. CONCLUSIONS:Although confirmatory studies are awaited, our work supports the role of the TB in defining risk groups of the stage II CC.

journal_name

Int J Colorectal Dis

journal_title

International journal of colorectal disease

authors

Romiti A,Roberto M,Marchetti P,Di Cerbo A,Falcone R,Campisi G,Ferri M,Balducci G,Ramacciato G,Ruco L,Pilozzi E

doi

10.1007/s00384-019-03279-1

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

905-913

issue

5

eissn

0179-1958

issn

1432-1262

pii

10.1007/s00384-019-03279-1

journal_volume

34

pub_type

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