Abstract：
PURPOSE:Crohn's disease (CD) commonly recurs after surgery, and a number of patients need repeated surgery, especially smokers and those with repeated surgeries or penetrating disease. Whether infliximab prevents postsurgical recurrence in high-risk CD remains unknown. In the present pilot open-labeled study, we investigated the safety and efficacy of scheduled infliximab, which was started early after surgery, in maintaining remission of CD patients who have undergone multiple surgeries due to penetrating disease. METHODS:Eleven patients (nine male, two female; age range, 26-48 years) who had undergone repeated surgeries (median, 4; range, 2-5) for penetrating disease were enrolled. Two to 4 weeks after surgery, the patients were started on intravenous infliximab (5 mg/kg) at an 8-week interval. The primary end points were the proportion of patients in clinical remission at the end of the study, the rate of endoscopic/radiologic remission at 24 months, and the rate of adverse effects. RESULTS:One patient dropped out due to non-compliance, and ten patients were eligible for analysis. Clinical remission was maintained in six of ten patients (60.0%) at the end of the study. At 24 months, four out of ten patients were in endoscopic or radiological remission (40.0%). Two patients experienced adverse effects (18.2%), one of whom elected to withdraw from the study. CONCLUSION:The findings of no major safety concern and possible clinical benefit in our study suggest that further investigation of infliximab as a treatment for prevention of postsurgical recurrence in high-risk CD is warranted.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Sakuraba A,Sato T,Matsukawa H,Okamoto S,Takaishi H,Ogata H,Iwao Y,Hibi Tdoi
10.1007/s00384-011-1398-ysubject
Has Abstractpub_date
2012-07-01 00:00:00pages
947-52issue
7eissn
0179-1958issn
1432-1262journal_volume
27pub_type
临床试验,杂志文章abstract：BACKGROUND:Extrarenal retroperitoneal angiomyolipomas are benign tumours of mesenchymal tissue origin. The diagnosis of these tumours is usually based on the perioperative findings and confirmed by the resultant specimen's histology. The main differential diagnosis is liposarcoma, and accurate preoperative imaging comb...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-003-0492-1
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Several studies over the last 20 years have confirmed the safety and efficacy of strictureplasty in the treatment of obstructive Crohn's disease. However, almost all of these studies use strictureplasty to treat fibrotic strictures: limited resection being preferred to treat active disease stricture...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-005-0029-x
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:For asymptomatic individuals aged 40-49 years, screening for colorectal cancer is recommended only if individuals are at an increased risk. A family history of colon cancer (FHCRC) is considered to increase risk, however, whether family history of stomach cancer (FHSC) increases the risk of adenoma is not we...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-009-0855-3
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:The aim of this study was to determine the short- and long-term relative survival as well as the causes of death in patients treated in hospital for acute colonic diverticulitis. MATERIALS AND METHODS:The study included all patients treated at Levanger Hospital for acute colonic diverticulitis between 1988 and...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-014-1946-3
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:ERAS (enhanced recovery after surgery) programs have proven to reduce morbidity and hospital stay in colorectal surgery. However, the feasibility of these programs in elderly patients has been questioned. The aim of this study is to assess the implementation and outcomes of an ERAS program for colorectal cancer...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,多中心研究
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abstract：AIM:The aim of this study was to analyze the results of nonoperative management of patients with perforated acute diverticulitis with extraluminal air and to identify risk factors that may lead to failure and necessity of surgery. METHODS:Methods included observational retrospective cohort study of patients between 20...
journal_title：International journal of colorectal disease
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doi：10.1007/s00384-017-2852-2
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:There are no published data or guidelines on whether the same anti-tumor-necrosis factor (TNF) agents used preoperatively or different anti-TNF agents are preferable to treat postoperative recurrence. Our aim was to compare the efficacy of the consistent vs. switched anti-TNF approaches in patients with recurre...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2632-4
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND AND AIMS:The aim of this study was to determine the detection rate of polyps using zoom chromoendoscopy (ZE) compared with standard video colonoscopy. PATIENTS AND METHODS:End-to-end colonoscopies were performed in 50 patients by two different endoscopists blinded for each other's results. Lesions detected ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-005-0052-y
更新日期：2006-09-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840050147
更新日期：1998-01-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2498-x
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Diversion colitis (DC) seems to be common in stoma patients, and the restoration of the continuity of the digestive tract is crucial for relief from the inflammatory process. No prospective studies of the late effects of DC on the lower gastrointestinal (GI) tract mucosa and the clinical condition of patient...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-017-2802-z
更新日期：2017-08-01 00:00:00
abstract：:The biomechanical properties and intestinal wall composition of left colon were studied in 4-month-old, 14-month-old, and 27-month-old male rats. The hydroxyproline content and hydroxyproline concentration in old rats were increased by 36% and 26%, respectively, compared with young rats and by 20% and 17%, respectivel...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00341292
更新日期：1992-06-01 00:00:00
abstract：PURPOSE:This study investigates whether contrast enema (CE) and flexible endoscopy (FE) should be performed routinely after low anterior resection (LAR) before ileostomy reversal. Additionally, the impact of previous anastomotic leakage (AL) on diagnostic test accuracy (DTA) was assessed. METHODS:This is a retrospecti...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03766-w
更新日期：2021-02-01 00:00:00
abstract：PURPOSE:Stage II colon cancer (CC) represents a challenging scenario for the choice of adjuvant chemotherapy; here, histologic factors need to be weighed up to establish the risk of recurrence. Tumor budding (TB) has recently been indicated as a confident predictor of clinical outcome in CC. Likewise, the presence of p...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
abstract：PURPOSE:Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) compared with other wound therapy techniques. However, the method has occasionally been associated with increased development of intestinal fistulae. The present study measures microvascular blood flow in the...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-011-1317-2
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:We evaluated the efficacy of oral administration of a mixture of diosmin, coumarin glycosides, and Centella asiatica (Venoplant®) in preventing bleeding, pain, and thrombosis of internal and external hemorrhoids after stapled anopexy (SA). METHODS:SA was conducted in 182 patients with third-degree hemorrhoids....
journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-016-2698-z
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to explore the effects of the fast-track surgery (FTS) program on inflammation and immunity in patients undergoing colorectal surgery. METHODS:From August 2014 to March 2015, a prospective and randomized controlled trial of 230 patients who underwent colorectal surgery was perf...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-016-2630-6
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Haemorrhoidal disease is one of the most common anorectal disorders. The aim of this study is to compare the results, over the last 10 years, of stapled haemorrhoidopexy (SH) with those of standard Milligan-Morgan haemorrhoidectomy (M&M). Furthermore, we discuss the proper indications for each technique in term...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-011-1342-1
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Diverticular disease is a common, chronic inflammatory disease of the bowel. This study investigates the differences in body composition between patients with diverticular disease and those without. METHODS:Appropriate patients were identified using a search of the radiology database. Demographic and diseas...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-3058-y
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy. MATERIALS AND METHODS:Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer. RESULTS:The IGF system...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
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更新日期：2006-04-01 00:00:00
abstract：PURPOSE:Serological tumor markers are routinely used to monitor tumor onset and progression. In colorectal carcinoma (CRC), the carcinoembryonic antigen (CEA) is roughly elevated in 50% of patients at initial diagnosis. Soluble ICAM-1 (sICAM-1) is elevated in different cancers. The aim of this study was to evaluate the...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-007-0275-1
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:The transcription factor NF-kappaB is believed to play a key pathophysiological role in chronic intestinal inflammation. Further characterization of its mechanism of regulation, predominantly through cell signaling pathways, may provide clues as to the means of its intervention. One such potential signaling ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-006-0193-7
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:Postoperative ileus (POI) occurrence within enhanced recovery programs (ERPs) has decreased. Also, intra-abdominal complications (IAC) such as anastomotic leakage (AL) generally present late. The aim was to characterize the link between POI and the other complications occurring after surgery. METHODS:This retr...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-3165-9
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Anastomotic dehiscence is the most severe surgical complication after large bowel resection. This study was designed to assess the incidence, to observe the consequences, and to identify the risk factors associated with anastomotic leakage after colorectal surgery. MATERIALS AND METHODS:All procedures invol...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-007-0399-3
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:This study aims to evaluate pubovisceral muscle and anal sphincter defects in women with previous vaginal delivery and fecal incontinence and to correlate the findings with the severity of symptoms using the combined anorectal and endovaginal 3D ultrasonography with a new ultrasound scoring system. METHODS:Con...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2750-z
更新日期：2017-04-01 00:00:00
abstract：:Rectal endosonography can be used to detect and localise recurrent rectal carcinoma. Distal and proximal to a rectal anastomosis the separate layers of the bowel wall as seen by rectal endosonography are well defined but at the precise level of the anastomosis separation of the layers is lost and they appear to merge....
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00300400
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Hereditary nonpolyposis colorectal cancer (HNPCC) and a subset of sporadic colorectal cancers are characterized by microsatellite instability (MSI) and inactivating frameshift mutations of target genes. Inactivation of BAX, caspase-5 ( cas-5), and other genes coding for pro-apoptotic proteins might ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-004-0597-1
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:Our study is the first meta-analysis to compare total mesorectal excision (TME) plus lateral lymph node dissection (LLND) with TME on rectal cancer patients regarding outcomes including overall survival, disease-free survival, local recurrence, complications, urinary dysfunction, and sexual dysfunction. METH...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s00384-020-03610-1
更新日期：2020-06-01 00:00:00
abstract：:The heterogeneity in the DNA content was analysed in multiple biopsies from the surgical specimens in 77 cases of colonic and 46 cases of rectal adenocarcinomas. Frozen and unfixed tumour tissue was analysed with the flow cytometric technique. A total of 78/123 (63%) of all tumours displayed aneuploid stemlines in one...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00300207
更新日期：1991-05-01 00:00:00
