Abstract：
:The heterogeneity in the DNA content was analysed in multiple biopsies from the surgical specimens in 77 cases of colonic and 46 cases of rectal adenocarcinomas. Frozen and unfixed tumour tissue was analysed with the flow cytometric technique. A total of 78/123 (63%) of all tumours displayed aneuploid stemlines in one or more pieces of tumour tissue; 45 were homogeneously aneuploid and 33 were heterogeneous, presenting both aneuploid and near-diploid samples. The remaining 45 tumours were homogeneously near-diploid. The heterogeneity in ploidy tended to be slightly higher if ten as compared with four samples from each tumour were analysed. Ploidy correlated to localization in the bowel and gender, but not to age, histopathological tumour stage, tumour differentiation or to the resectability rate for cure. The mean value of the S-phase fraction was 17% (range 7-31%) in the near-diploid and 14% (range 8-20%) in the aneuploid tumours. The range of the intratumoural variation was small for the DNA index (at most 5%) and high for the S-phase fraction (19% for near-diploid and 24% for aneuploid tumour pieces). Neither the mean value nor the heterogeneity in the DNA index and in the S-phase fraction displayed any correlation with the studied characteristics. In conclusion, the ploidy and the S-phase fraction varied considerably both within and between the tumours. As a consequence, multiple sampling is mandatory for a correct classification of colorectal adenocarcinomas based on the DNA content.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Lindmark G,Glimelius B,Påhlman L,Enblad Pdoi
10.1007/BF00300207subject
Has Abstractpub_date
1991-05-01 00:00:00pages
115-20issue
2eissn
0179-1958issn
1432-1262journal_volume
6pub_type
杂志文章abstract：PURPOSE:The favorable oncological impact of D3 lymph node dissection after colon cancer surgery has been described previously. However, D3 lymph node dissection is potentially more invasive than conventional D2 lymph node dissection. The oncological merit of D3 lymph node dissection in elderly patients with colon cance...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-03233-7
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Increasing the rate of pathological complete remissions after neoadjuvant chemoradiation of rectal cancer has become a strategy to further improve the long-term oncological outcome of patients. This report evaluates the influence of preoperative intensified radiochemotherapy on the rate and outcome of surgic...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-007-0408-6
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:Short-segment Hirschsprung disease (HSCR) is the predominant type of HSCR that affects approximately 75% of patients. Whether single-stage endorectal pull-through (ERPT) surgery is appropriate for neonatal patients with HSCR has not been definitively determined. This retrospective cohort study concerning infa...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-3179-3
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:Pelvic radiotherapy may lead to changes of anorectal function resulting in incontinence-related complaints. The aim of this study was to systematically review objective findings of late anorectal physiology and mucosal appearance after irradiation for prostate cancer. METHODS:MEDLINE, EMBASE, and the Cochrane ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s00384-013-1784-8
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:The oncological benefits of achieving a complete pathological response following neoadjuvant chemoradiotherapy for rectal cancer are well defined. How a pathological response affects anastomotic healing or leak rates is not clear. The aim of this systematic review was to compare anastomotic leak rates among pat...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s00384-021-03833-w
更新日期：2021-01-11 00:00:00
abstract：INTRODUCTION:When severe chronic pelvic pain, constipation, and bloating are due to dense pelvic adhesions fixing the sigmoid loops, patients may be offered the option of sigmoid colectomy. This study examines the effectiveness of colectomy in the treatment of such patients. METHODS:Patients were identified from a sur...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1711-z
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:The present study was performed to get a better insight in the incidence of anastomotic leakage leading to reintervention when using the C-seal: a biodegradable sheath that protects the stapled colorectal anastomosis from leakage. METHODS:The C-seal is a thin walled tube-like sheath that forms a protective she...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1724-7
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:Subtotal colectomy (STC) is performed for severe acute and refractory colitis. The diagnosis can be difficult even after the surgery when colectomy specimen has overlapping features of ulcerative colitis (UC) and Crohn's disease (CD). The aim of this study was to evaluate the rate of postoperative diagnostic re...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03783-9
更新日期：2020-10-21 00:00:00
abstract：OBJECTIVES:Inflammation is an important driver of abdominal pain in inflammatory bowel disease (IBD). However, some patients in remission still experience pain. We aimed to identify risk factors associated with abdominal pain in quiescent IBD (QP-IBD) and to characterize differences from patients with active disease ex...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03727-3
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Perianal fistulising Crohn's disease (PFCD) affects a third of Crohn's disease patients and represents a disabling phenotype with poor outcome. The anti-tumour necrosis factor alpha (TNF) therapies have been shown to maintain clinical remission in a third of patients after 1 year of treatment. Maintenance th...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
doi：10.1007/s00384-017-2899-0
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:Despite the recent growing interest of the scientific community, there is still no consensus on the actual applicability and effectiveness of sentinel lymph node (SL) procedure in colon cancers. This study aims to quantify feasibility, detection rate, negative predictive value, and accuracy of the SL identified...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-020-03654-3
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to identify clinical and pathological parameters to improve prediction of disease-free survival (DFS) and overall survival (OS) in patients treated with neoadjuvant chemoradiotherapy for rectal cancer. METHODS:Between July 1995 and May 2007, 148 patients with primary rectal ade...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-009-0682-6
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND AND AIMS:Malignant cells often exhibit perturbations in the pattern of cytosine methylation. Hypermethylation of CpG islands has been extensively documented, but genome-wide hypomethylation is also a common feature of malignant cells. The bulk of cytosine methylation in the mammalian genome occurs on repetit...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-003-0539-3
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:Bile acid malabsorption (BAM) is a common cause of diarrhoea in Crohn's disease (CD) patients with ileal resection. BAM is usually diagnosed by selenium-labelled homotaurocholic acid test (75SeHCAT) but its availability is limited. Consequently, a large proportion of patients either remain undiagnosed or subjec...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-018-3144-1
更新日期：2019-01-01 00:00:00
abstract：:Leukocyte emigration from blood to sites of inflammation involves sequential interaction of specific adhesion molecules expressed by both leukocytes and endothelial cells. The central steps in leukocyte-endothelial adhesive interactions are leukocyte rolling, sticking, and transmigration. This study investigated the e...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s003840050214
更新日期：1999-11-01 00:00:00
abstract：BACKGROUND:The transcription factor NF-kappaB is believed to play a key pathophysiological role in chronic intestinal inflammation. Further characterization of its mechanism of regulation, predominantly through cell signaling pathways, may provide clues as to the means of its intervention. One such potential signaling ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-006-0193-7
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND AND STUDY AIMS:Computer-generated enhancements, which can highlight the surface and color of a colonic lesion, may be helpful to predict the histology; however, it remains unclear whether this technology can distinguish neoplastic from non-neoplastic colon polyps when the polyps are <1 cm without magnificati...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-011-1319-0
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND AND AIMS:This study used postoperative defecography to characterize morphological features of defecatory disorders in patients following rectal resection. We also evaluated differences in dynamic defecatory condition depending on reconstruction methods for sphincter-saving surgery. MATERIALS AND METHODS:Sub...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-008-0485-1
更新日期：2008-09-01 00:00:00
abstract：INTRODUCTION:The ileal pouch-anal anastomosis (IPAA) has become a standard procedure for patients with ulcerative colitis requiring surgical intervention. The technique has greatly improved and, since 1990, all patients at Huddinge University Hospital have been operated on with the double stapled technique. Pelvic seps...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-004-0717-y
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Ostomies are being placed in 35 % of patients after colorectal cancer surgery. As decision-making regarding colorectal surgery is challenging in the older patients, it is important to have insight in the potential impact due to ostomies. METHODS:An internet-based survey was sent to all members with register...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2665-8
更新日期：2017-01-01 00:00:00
abstract：AIMS:Percutaneous tibial nerve stimulation (PTNS) and sacral nerve stimulation (SNS) are both second-line treatments for faecal incontinence (FI). To compare the clinical outcomes and effectiveness of SNS versus PTNS for treating FI in adults. METHOD:A literature search of MEDLINE, Embase, Science Citation Index Expan...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00384-018-2976-z
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:Colorectal cancer is a common malignancy and one of the major causes of cancer-related deaths worldwide. Similar to other human cancers, tumor metastasis is the biggest obstacle in the clinical treatment of colorectal cancer. In this study, we explored the functional role of SLIT2 in colon tumor metastasis and ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1641-9
更新日期：2013-07-01 00:00:00
abstract：AIM:This study aims to evaluate the prognostic value of CD45RO(+) tumor-infiltrating lymphocytes (TILs) in locally advanced rectal cancer treated with 30 Gy/10 fraction (10 f) neoadjuvant radiotherapy. METHODS:This retrospective study involved 185 patients with locally advanced rectal cancer who underwent 30 Gy/10 f n...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2226-6
更新日期：2015-06-01 00:00:00
abstract：:A combined manometric and radioisotope study is described which was designed to investigate the motility characteristics of induced defaecation in the colon, rectum and anal canal, in patients with severe constipation. Five women with severe idiopathic constipation, aged 30-45 years, were studied. A multiple channel w...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00341220
更新日期：1992-12-01 00:00:00
abstract：PURPOSE:This study aims to evaluate the role of colonic stenting as a bridge to surgery in acutely obstructed left-sided colon cancer. METHODS:Patients with acute left-sided malignant colonic obstruction with no evidence of peritonitis were recruited. After informed consent, patients were randomized to colonic stentin...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-011-1331-4
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Intestinal adenosquamous carcinoma (ASC) is a rare colorectal neoplasm frequently occurring at onset as a locally advanced disease with distant metastases. The liver is the most common site of metastasis, followed by the peritoneum and the lung. Cutaneous metastases from usual colorectal adenocarcinoma occ...
journal_title：International journal of colorectal disease
pub_type：
doi：10.1007/s00384-019-03464-2
更新日期：2020-02-01 00:00:00
abstract：:Since 1983 we have used radial and linear ultrasound probes in the laboratory and clinical examination of the rectum. Normal endosonographic appearances have been characterised by examining polyethylene membranes and resection specimens. Twenty normal subjects and 11 patients with rectal cancer have been examined, and...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF01648338
更新日期：1986-10-01 00:00:00
abstract：PURPOSE:The purposes of this study were to assess the working definition of a colorectal anastomotic leak among colorectal surgeons and to survey the current approach to investigation and management of a patient with a suspected anastomotic leak. METHODS:Online survey consisting of nine questions regarding the definit...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1640-x
更新日期：2013-07-01 00:00:00
abstract：AIM:Evidence is lacking whether an abscess associated with anastomotic leak after an ileal pouch-anal anastomosis (IPAA) should be drained by transanal or CT-guided drainage. Therefore, the aim of this study was to compare outcomes after the two techniques for drainage. METHOD:Patients who underwent IPAA (1984-2009) a...
journal_title：International journal of colorectal disease
pub_type： 临床试验,杂志文章
doi：10.1007/s00384-011-1272-y
更新日期：2011-11-01 00:00:00
abstract：PURPOSE:Tumor grade is a traditional prognostic parameter in colorectal cancer. Remarkably, however, there is still no generally accepted consensus how to perform tumor grading. In this study, we systematically compared the prognostic value of traditional grading based upon histological features, that is, gland formati...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2495-0
更新日期：2016-03-01 00:00:00
