Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue.

abstract：BACKGROUND AND AIM:Concurrent definitive treatment of underlying fistulas from infected anal glands at the time when the anorectal abscesses are drained is controversial as this is associated with a higher incidence of faecal incontinence, failure and recurrence. This meta-analysis was conducted to determine the merits...

journal_title：International journal of colorectal disease

authors： Quah HM,Tang CL,Eu KW,Chan SY,Samuel M

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The clinicopathological roles and relationships of hTERT, p21 and p53 proteins have not been studied in depth in colorectal cancer. The aim of the present study is to investigate the clinicopathological roles of expression of hTERT protein expression and its relationship with the expression of p21 and p53 pr...

journal_title：International journal of colorectal disease

authors： Lam AK,Ong K,Ho YH

更新日期：2008-06-01 00:00:00

abstract：:This study evaluates anorectal function after combined tele- and brachytherapy for anal cancer using manometric measurements and a standardized questionnaire. Eight patients received 44 +/- 3 Gy external beam radiation followed by 20 +/- 4 Gy interstitial brachytherapy with iridium-192. Patients were examined 43 month...

journal_title：International journal of colorectal disease

authors： Broens P,Van Limbergen E,Penninckx F,Kerremans R

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND AIMS:This study determined correlations of clinical and manometric features with those of anal endosonography (AES). PATIENTS AND METHODS:Between 1996 and 1999 we examined 58 patients suffering from anal incontinence (AI) by AES using a linear probe and anorectal manometry following a standardized proto...

journal_title：International journal of colorectal disease

authors： Barthet M,Bellon P,Abou E,Portier F,Berdah S,Lesavre N,Orsoni P,Bouvier M,Grimaud JC

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Infections are the leading cause of morbidity and mortality after colorectal surgery. Obesity is a well-known risk factor for wound infection, but it does not seem to increase the risk of other infectious complications. The aim of this study was to look for a relationship between the fatty tissue metabolism ...

journal_title：International journal of colorectal disease

authors： Ortega-Deballon P,Duvillard L,Scherrer ML,Deguelte-Lardière S,Bourredjem A,Petit JM,Bonithon-Kopp C,AGARIC Study group.

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to identify rates and factors associated with permanent diversion following restorative proctosigmoidectomy for rectal cancer when complicated by an anastomotic leak. DESIGN:This study is a retrospective review. SETTING:The setting of this study is a tertiary referral hospital...

journal_title：International journal of colorectal disease

authors： Ogilvie JW Jr,Dietz DW,Stocchi L

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Standard therapy for locally advanced rectal cancer (LARC) is concurrent neo-adjuvant chemo-radiation using infusional 5-fluorouracil (CIV-5-FU). Capecitabine (CAP) offers a convenient oral replacement for CIV-5-FU. There is no randomized trial comparing infusional 5-FU to capecitabine. We retrospectively co...

journal_title：International journal of colorectal disease

authors： Saif MW,Hashmi S,Zelterman D,Almhanna K,Kim R

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:Acute urinary retention (AUR) is a common postoperative complication in colorectal surgery. In pelvic colorectal operations, the optimal duration for postoperative urinary catheter use is controversial. This systematic review and meta-analysis aims to compare early (POD 1), intermediate (POD 3), and late (POD 5...

journal_title：International journal of colorectal disease

authors： Lee Y,McKechnie T,Springer JE,Doumouras AG,Hong D,Eskicioglu C

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Ileal pouch-anal anastomosis (IPAA) has been established as the procedure of choice for patients who require excision of the colon and rectum for familial adenomatous polyposis and ulcerative colitis. The requirement for proximal stomal diversion in IPAA is controversial. OBJECTIVES:To compare post-operative o...

journal_title：International journal of colorectal disease

authors： Khan K,Manzoor T,Khan S,Hartley JE

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:To clarify the risk factors of lateral pelvic lymph node (LPLN) metastasis of rectal cancer, we examined associations between LPLN status and clinicopathological factors including LPLN status diagnosed by computed tomography (CT). METHODS:We reviewed a total of 210 patients with advanced rectal cancer, of w...

journal_title：International journal of colorectal disease

authors： Fujita S,Yamamoto S,Akasu T,Moriya Y

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/AIM:In order to define future chemoprevention strategies for adenomas or carcinomas in the pouch of patients with familial adenomatous polyposis (FAP), a 4-weeks intervention with (1) sulindac, (2) inulin/VSL#3, and (3) sulindac/inulin/VSL#3 was performed on 17 patients with FAP in a single center interventi...

journal_title：International journal of colorectal disease

authors： Friederich P,Verschuur J,van Heumen BW,Roelofs HM,Berkhout M,Nagtegaal ID,van Oijen MG,van Krieken JH,Peters WH,Nagengast FM

更新日期：2011-05-01 00:00:00

abstract：:An audit was performed of 77 patients with a single colorectal cancer visualised and sited before surgery by colonoscopic examination. The site of the cancer described at colonoscopy was compared with the actual site found at laparotomy. Six significant errors in preoperative localisation were encountered, when a chan...

journal_title：International journal of colorectal disease

authors： Hancock JH,Talbot RW

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to develop a method by which rectal and colonic activity could be examined during defaecation under physiological conditions, in order to evaluate whether the colon plays a role in defaecation. Subjects presented to the Nuclear Medicine department on the day following ingestion of oral In-111...

journal_title：International journal of colorectal disease

authors： Lubowski DZ,Meagher AP,Smart RC,Butler SP

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:High level of microsatellite instability (MSI-H) in colorectal cancer (CRC) is caused by the inactivation of mismatch repair (MMR) genes; however, it is unknown for tumors with low level MSI (MSI-L). The protein complex involving MSH3 preferentially recognizes insertion/deletion loops (IDLs) of two to eight bas...

journal_title：International journal of colorectal disease

authors： Plaschke J,Preußler M,Ziegler A,Schackert HK

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Crohn's disease is intractable and is frequently diagnosed in younger people. No clear policies exist regarding medical treatment for seniors with this disease, and its diagnosis and treatment are often hindered by difficulties attributable to comorbidities, complex differential diagnoses, and polypharmacy. ...

journal_title：International journal of colorectal disease

authors： Iwamoto M,Kato K,Moriyama M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Rectovaginal fistulas in patients with Crohn's disease are difficult to resolve, and surgical failure is very frequent. Recent studies have shown that adult stem cells extracted from certain tissues, such as adipose tissue, can develop into different tissues, such as muscle. PATIENT AND METHODS:We ...

journal_title：International journal of colorectal disease

authors： García-Olmo D,García-Arranz M,García LG,Cuellar ES,Blanco IF,Prianes LA,Montes JA,Pinto FL,Marcos DH,García-Sancho L

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to explore the effects of the fast-track surgery (FTS) program on inflammation and immunity in patients undergoing colorectal surgery. METHODS:From August 2014 to March 2015, a prospective and randomized controlled trial of 230 patients who underwent colorectal surgery was perf...

journal_title：International journal of colorectal disease

authors： Feng J,Li K,Li L,Wang X,Huang M,Yang J,Hu Y

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Large bowel obstruction and megacolon formation secondary to complicated diverticulitis is rare. METHODS:We present a case of an 84-year-old woman surviving large bowel obstruction and mega-megacolon formation secondary to complicated diverticulitis, with an impressive presentation of abdominal distention. RE...

journal_title：International journal of colorectal disease

authors： Larentzakis A,Kalyva A,Kantas T,Michalopoulos NV,Zografos CG,Zografos GC

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Cervical vagus nerve stimulation (VNS) prevents manipulation-induced intestinal inflammation and improves intestinal transit in a mouse model of postoperative ileus (POI). Cervical VNS, however, is accompanied by cardiovascular and respiratory side effects. In view of potential clinical application, we therefor...

journal_title：International journal of colorectal disease

authors： Wolthuis AM,Stakenborg N,D'Hoore A,Boeckxstaens GE

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The phenomenon of prostaglandin dependent adaptive cytoprotection has been well established in the stomach and duodenum but not in the colon. This study investigated whether it also occurs in the colon. METHODS:Fisher rats received intracolonic administration (0.5 ml) of saline or acetic acid at lo...

journal_title：International journal of colorectal disease

authors： Kono T,Yoneda M,Ohara K,Ayabe T,Chisato N,Kohgo Y,Kasai S,Terano A,Taché Y

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:Lymph node (LN) yield is a critical component of colon cancer staging and is often a surrogate for quality assessment in surgery. We investigated the impact of pathologists' training on LN harvest. METHODS:This is a retrospective review on 137 patients undergoing elective colectomy for adenocarcinoma at a sing...

journal_title：International journal of colorectal disease

authors： Bamboat ZM,Deperalta D,Dursun A,Berger DL,Bordeianou L

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy. MATERIALS AND METHODS:Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer. RESULTS:The IGF system...

journal_title：International journal of colorectal disease

authors： Davies M,Gupta S,Goldspink G,Winslet M

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Hereditary nonpolyposis colorectal cancer (HNPCC) and a subset of sporadic colorectal cancers are characterized by microsatellite instability (MSI) and inactivating frameshift mutations of target genes. Inactivation of BAX, caspase-5 ( cas-5), and other genes coding for pro-apoptotic proteins might ...

journal_title：International journal of colorectal disease

authors： Trojan J,Brieger A,Raedle J,Weber N,Kriener S,Kronenberger B,Caspary WF,Zeuzem S

更新日期：2004-11-01 00:00:00

abstract：:Twenty-one patients suffering from rectal prolapse (n = 15) or internal rectal procidentia (n = 6) were investigated clinically and by anorectal manometry prior to and six months following retopexy. Rectal prolapse was associated with incontinence in 67% (10/15) of the patients preoperatively. The moderately or severe...

journal_title：International journal of colorectal disease

authors： Brodén G,Dolk A,Holmström B

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:The main operative method in familial adenomatous polyposis (FAP) patients is restorative proctocolectomy with "J"-shaped pouch and temporary loop ileostomy. The aim of the study was the analysis of the frequency of the dysplasia and inflammation in the intestinal pouch and prognosis of the clinical course in F...

journal_title：International journal of colorectal disease

authors： Banasiewicz T,Marciniak R,Kaczmarek E,Krokowicz P,Paszkowski J,Lozynska-Nelke A,Gronek P,Plawski A,Drews M

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:Anastomotic leak (AL) in colorectal surgery leads to significant morbidity, mortality and poorer oncological outcomes. Diagnosis of AL is frequently delayed as current methods of detection are not 100% sensitive or specific. 'Biomarkers', such as cytokines and markers of ischaemia, from the milieu of the anasto...

journal_title：International journal of colorectal disease

authors： Wright EC,Connolly P,Vella M,Moug S

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:Kras mutations are negative predictors of anti-EGFR therapy, occurring in 40% of colorectal carcinomas (CRCs). Point substitutions in codon 12 or 13 are the most frequent mutations in Kras, but multiple mutations (MMs) in other codons can also develop. Few data exist on MMs with regard to their frequency and th...

journal_title：International journal of colorectal disease

authors： Macedo MP,Andrade Lde B,Coudry R,Crespo R,Gomes M,Lisboa BC,Aguiar S Jr,Soares FA,Carraro DM,Cunha IW

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Although some studies have reported differences in clinicopathological features between left- and right-sided advanced colorectal cancer (CRC), there are few reports regarding early-stage disease. In this study, we aimed to compare the clinicopathological features of left- and right-sided T1 CRC. METHODS:Subje...

journal_title：International journal of colorectal disease

authors： Mochizuki K,Kudo SE,Ichimasa K,Kouyama Y,Matsudaira S,Takashina Y,Maeda Y,Ishigaki T,Nakamura H,Toyoshima N,Mori Y,Misawa M,Ogata N,Kudo T,Hayashi T,Wakamura K,Sawada N,Ishida F,Miyachi H

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Ulcerative colitis is an established risk factor for colorectal cancer but dysplasia reports are much more frequent than invasive neoplasm diagnosis. The effective activation of T lymphocytes that provide antitumor surveillance requires the presence of costimulation molecules such as CD80 and CD86 o...

journal_title：International journal of colorectal disease

authors： Scarpa M,Behboo R,Angriman I,Cecchetto A,D'Incà R,Termini B,Barollo M,Ruffolo C,Polese L,Sturniolo GC,D'Amico DF

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The transcription factor NF-kappaB is believed to play a key pathophysiological role in chronic intestinal inflammation. Further characterization of its mechanism of regulation, predominantly through cell signaling pathways, may provide clues as to the means of its intervention. One such potential signaling ...

journal_title：International journal of colorectal disease

authors： Parhar K,Morse J,Salh B

更新日期：2007-06-01 00:00:00