Abstract:
BACKGROUND:Infections are the leading cause of morbidity and mortality after colorectal surgery. Obesity is a well-known risk factor for wound infection, but it does not seem to increase the risk of other infectious complications. The aim of this study was to look for a relationship between the fatty tissue metabolism measured by adipocytokine levels and the risk of postoperative infection. PATIENTS AND METHODS:Preoperative plasma levels of eight adipocytokines, cholesterol, triglycerides, insulin and C-reactive protein (CRP) were measured in consecutive patients undergoing elective colorectal surgery between June 2008 and June 2011. Information about epidemiological and clinical characteristics was obtained for each patient. All infections in the 30 days following surgery were recorded. RESULTS:Among the 174 patients included, 49 (28 %) presented with a postoperative infection: 41 surgical site infections and 8 other infections. Preoperative leptin, insulin and CRP were significantly higher in patients with postoperative infection (p = 0.025, p = 0.020 and p = 0.044, respectively), but only leptin was predictive of infection in multivariate analysis (odds ratio (OR) = 1.89, 95 % confidence interval (CI) 1.18-3.03, p = 0.008). The predictive value of leptin was slightly lower for surgical site infection (OR = 1.65, 95 % CI 1.06-2.55, p = 0.025). Leptin levels were independent of the other adipocytokine levels but not of the body mass index. CONCLUSION:Although markers of inflammation and insulin resistance are also related to the onset of surgical infection, leptin correlates more closely with the risk of infection than does any other factor. However, its effect could be partially mediated by the body mass index.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Ortega-Deballon P,Duvillard L,Scherrer ML,Deguelte-Lardière S,Bourredjem A,Petit JM,Bonithon-Kopp C,AGARIC Study group.doi
10.1007/s00384-013-1782-xsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
23-9issue
1eissn
0179-1958issn
1432-1262journal_volume
29pub_type
杂志文章abstract:PURPOSE:Although small rectal carcinoid tumors can be treated using local excision, complete resection can be difficult because tumors are located in the submucosal layer. We evaluate the factors associated with pathologically complete local resection of rectal carcinoid tumors. METHODS:Data were analyzed of 161 patie...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
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journal_title:International journal of colorectal disease
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更新日期:2011-05-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-12-01 00:00:00
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