Abstract：
INTRODUCTION:Constipation is frequently seen in patients with mental retardation (MR). Its pathophysiology is poorly understood. Measurement of colon transit time (CTT) differentiates between retentive and non-retentive constipation. AIM:To determine total and segmental CTT in MR patients compared to healthy controls. METHOD:Of 250 residents, 60 patients older then 16, without swallowing disorder or scoliosis, are randomly chosen, 58 participated (intelligence quotient < 50, median age 35.5 year, 29 male). Constipation was defined as less than three defecations a week. Controls are 32 non-constipated age-matched healthy volunteers (median age 29 year, 19 male). CTT is measured by daily administration of ten radio-opaque markers during 6 days and abdominal X-ray on day 7. CTT is calculated using Bouchoucha's [7] method. RESULTS:Compared to controls, total CTT is significantly (P < 0.001) longer in MR (median 22.8 h vs. 57.6 h, respectively). Of the MR patients, 21/58 (36%) are constipated. The mental retardated and constipated (MRC) have a significant prolonged CTT in all segments (P < 0.01; median right CTT 19.2 h vs. 4.8 h; left CTT 14.4 h vs. 4.8 h; rectosigmoidal CTT 42 h vs. 9.6 h), whereas in mental retarded non-constipated (MRNC) persons, the rectosigmoidal CTT is prolonged (median 21.6 h vs. 9.6 h). CONCLUSION:Patients with moderate to deep MR have a significantly prolonged total CTT. In MRNC persons, rectosigmoidal CTT prolongation suggests a defecation problem. In MRC, CTT is prolonged in all segments, suggesting diffuse colonic inertia problem.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Vande Velde S,Van Biervliet S,Van Goethem G,De Looze D,Van Winckel Mdoi
10.1007/s00384-010-0928-3subject
Has Abstractpub_date
2010-07-01 00:00:00pages
867-71issue
7eissn
0179-1958issn
1432-1262journal_volume
25pub_type
临床试验,杂志文章abstract：:In 15 patients suffering from idiopathic faecal incontinence and in 15 matched controls, manometric studies of anorectal pressure and studies of the rectoanal reflex and rectal sensitivity were carried out. Patients with idiopathic faecal incontinence had normal resting pressure but reduced squeeze and stress pressure...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF01647996
更新日期：1987-08-01 00:00:00
abstract：PURPOSE:Although some studies have reported differences in clinicopathological features between left- and right-sided advanced colorectal cancer (CRC), there are few reports regarding early-stage disease. In this study, we aimed to compare the clinicopathological features of left- and right-sided T1 CRC. METHODS:Subje...
journal_title：International journal of colorectal disease
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更新日期：2020-10-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2632-4
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abstract：BACKGROUND:Infections are the leading cause of morbidity and mortality after colorectal surgery. Obesity is a well-known risk factor for wound infection, but it does not seem to increase the risk of other infectious complications. The aim of this study was to look for a relationship between the fatty tissue metabolism ...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-013-1782-x
更新日期：2014-01-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-015-2226-6
更新日期：2015-06-01 00:00:00
abstract：AIM:An illustration of the diagnosis and management of tailgut cysts. MATERIALS AND METHODS:Two cases of tailgut cyst and a review of the literature. RESULTS:A female patient presented with acute urinary retention with a retrorectal mass felt during rectal examination and confirmed on ultrasound and magnetic resonanc...
journal_title：International journal of colorectal disease
pub_type： 杂志文章,评审
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更新日期：2009-03-01 00:00:00
abstract：PURPOSE:The oncological results of close distal resection margins (DM) have been mixed due to variations in perioperative treatment protocols and surgical expertise. With the increased application of sphincter-saving surgery in the management of rectal cancer, "close shave" DM is an increasingly encountered phenomenon....
journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2012-10-01 00:00:00
abstract：:A combined manometric and radioisotope study is described which was designed to investigate the motility characteristics of induced defaecation in the colon, rectum and anal canal, in patients with severe constipation. Five women with severe idiopathic constipation, aged 30-45 years, were studied. A multiple channel w...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00341220
更新日期：1992-12-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2008-03-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2016-02-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00384-012-1544-1
更新日期：2013-03-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00342463
更新日期：1996-01-01 00:00:00
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journal_title：International journal of colorectal disease
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更新日期：2018-03-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/s00384-016-2715-2
更新日期：2017-02-01 00:00:00
abstract：:The biomechanical properties and intestinal wall composition of left colon were studied in 4-month-old, 14-month-old, and 27-month-old male rats. The hydroxyproline content and hydroxyproline concentration in old rats were increased by 36% and 26%, respectively, compared with young rats and by 20% and 17%, respectivel...
journal_title：International journal of colorectal disease
pub_type： 杂志文章
doi：10.1007/BF00341292
更新日期：1992-06-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章
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journal_title：International journal of colorectal disease
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：1992-02-01 00:00:00
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journal_title：International journal of colorectal disease
pub_type： 杂志文章
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更新日期：1990-05-01 00:00:00
