当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF COLORECTAL DISEASE期刊下所有文献 > Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy.

Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy.

Abstract：

AIM:This study aims to evaluate the prognostic value of CD45RO(+) tumor-infiltrating lymphocytes (TILs) in locally advanced rectal cancer treated with 30 Gy/10 fraction (10 f) neoadjuvant radiotherapy. METHODS:This retrospective study involved 185 patients with locally advanced rectal cancer who underwent 30 Gy/10 f nRT (biologic equivalent dose, 30 Gy) followed by total mesorectal excision (TME) between August 2003 and October 2009. The density of CD45RO(+) TILs was assessed by immunohistochemistry using an image-analysis system and tissue microarray and was evaluated for its association with histopathologic features along with disease-free survival (DFS). RESULTS:Following neoadjuvant radiotherapy, the median density of CD45RO(+) TILs is 654/mm(2). High density of CD45RO(+) TILs was significantly associated with increased T and N downstaging effect (p = 0.006; p = 0.014), lesser-advanced T stage (p = 0.003) and TNM stage (p = 0.022). Prolonged DFS (89.0 vs. 68.1%) was also observed in CD45RO(+Hi) cases. On multivariate regression model, CD45RO(+) TILs (p = 0.026; odds ratio (OR), 0.436 (95% confidence interval (CI), 0.209-0.907)), tumor differentiation (p = 0.057; OR, 1.878 (95% CI, 0.982-3.593)), ypT stage (p = 0.066; OR, 2.383 (95% CI, 0.943-6.025)), and ypN stage (p = 0.009; OR, 2.612 (95% CI, 1.266-5.388)) were independent factors for DFS. CONCLUSION:The density of CD45RO(+) TILs cannot only predict tumor downstaging and ypTNM stage for rectal cancer following 30 Gy/10 f nRT but also promisingly predict long-term outcomes. These findings may be used to stratify patients and make alternative strategy of adjuvant treatment.

journal_name

Int J Colorectal Dis

journal_title

International journal of colorectal disease

authors

Wang L,Zhai ZW,Ji DB,Li ZW,Gu J

doi

10.1007/s00384-015-2226-6

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

753-60

issue

6

eissn

0179-1958

issn

1432-1262

journal_volume

30

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE文献大全
  • Duodenal GIST: a single center experience.

    abstract：PURPOSE:The duodenum as primary site for gastrointestinal stromal tumors (GISTs) is rare and mitotic rate, tumor size, type of mutation and number of chromosomal aberrations have prognostic implications. METHODS:We analyzed the outcome of 13 patients with duodenal GISTs who underwent surgical tumor resection. Either s...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-012-1432-8

    authors： Beham A,Schaefer IM,Cameron S,von Hammerstein K,Füzesi L,Ramadori G,Ghadimi MB

    更新日期：2013-04-01 00:00:00

  • Evaluation of four comorbidity indices and Charlson comorbidity index adjustment for colorectal cancer patients.

    abstract：INTRODUCTION:Cancer survival is related not only to primary malignancy but also to concomitant nonmalignant diseases. The aim of this study was to investigate the prognostic capacity of four comorbidity indices [the Charlson comorbidity index (CCI), the Elixhauser method, the National Institute on Aging (NIA) and Natio...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-014-1972-1

    authors： Marventano S,Grosso G,Mistretta A,Bogusz-Czerniewicz M,Ferranti R,Nolfo F,Giorgianni G,Rametta S,Drago F,Basile F,Biondi A

    更新日期：2014-09-01 00:00:00

  • Laparoscopic sphincter-preserving surgery (intersphincteric resection) after neoadjuvant imatinib treatment for gastrointestinal stromal tumor (GIST) of the rectum.

    abstract：BACKGROUND:Gastrointestinal stromal tumors (GISTs) of the rectum are rarely found, and radical surgery such as abdominoperineal resection would be necessary for large rectal GIST. On the other hand, therapy for GIST has changed significantly with the use of imatinib. Neoadjuvant imatinib therapy may reduce tumor size a...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-013-1769-7

    authors： Fujimoto Y,Akiyoshi T,Konishi T,Nagayama S,Fukunaga Y,Ueno M

    更新日期：2014-01-01 00:00:00

  • Comparison of inpatient and outpatient upper gastrointestinal haemorrhage.

    abstract：BACKGROUND AND AIMS:Inpatients developing upper gastrointestinal (GI) haemorrhage are at increased risk of death. This study was performed to elucidate differences in inpatients and outpatients. PATIENTS/METHODS:Three hundred and sixty-two patients who needed esophagogastroduodenoscopy for upper GI bleeding were ident...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-004-0642-0

    authors： Klebl FH,Bregenzer N,Schöfer L,Tamme W,Langgartner J,Schölmerich J,Messmann H

    更新日期：2005-07-01 00:00:00

  • Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin.

    abstract：BACKGROUND:Tight junction (TJ) proteins play a critical role in cellular adhesion, glandular differentiation, and cellular proliferation. The function of these proteins is compromised in a number of intestinal diseases, including ulcerative colitis that has an increased incidence for colorectal carcinoma (CAC). The aim...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-009-0653-y

    authors： Mees ST,Mennigen R,Spieker T,Rijcken E,Senninger N,Haier J,Bruewer M

    更新日期：2009-04-01 00:00:00

  • Benefits of laparoscopic peritoneal lavage for complicated sigmoid diverticulitis.

    abstract：BACKGROUND:The traditional therapy for perforated sigmoid diverticulitis with peritonitis is emergency colectomy usually with colostomy. We report laparoscopic exploration with peritoneal lavage as an alternative in seven patients who required emergency surgery for diverticulitis. METHODS:Six patients presented with d...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-009-0641-2

    authors： Favuzza J,Friel JC,Kelly JJ,Perugini R,Counihan TC

    更新日期：2009-07-01 00:00:00

  • Association between increased tumor necrosis factor alpha levels and acquired activated protein C resistance in patients with metastatic colorectal cancer.

    abstract：PURPOSE:The purpose of this study was to investigate the possible association between tumor necrosis factor-α (TNF-α) levels and defects in the activated protein C (APC) system as a determinant of venous thromboembolism (VTE) in metastatic colorectal cancer patients (mCRC) undergoing chemotherapy. METHODS:TNF-α levels...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-012-1493-8

    authors： Ferroni P,Riondino S,Portarena I,Formica V,La Farina F,Martini F,Massimiani G,Palmirotta R,Guadagni F,Roselli M

    更新日期：2012-12-01 00:00:00

  • Is emergency right hemicolectomy still associated with significant morbidity and mortality rates? An institution's experience of 207 cases over 6 years.

    abstract：INTRODUCTION:Emergency right hemicolectomy has been associated with dismal outcome. But, data in Asians is lacking as pathologies that require emergency right hemicolectomy may differ from that in the Western population. The aims of our study were to review our institution's experience with emergency right hemicolectom...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-011-1203-y

    authors： Tan KK,Liu JZ,Yeow Y,Gunasekaran S,Tan JJ

    更新日期：2011-09-01 00:00:00

  • Topical anal fissure treatment: placebo-controlled study of mononitrate and trinitrate therapies.

    abstract：AIM:The present study aims to evaluate and compare the efficacy of two nitrate gels, containing isosorbide-5-mononitrate (ISMN) or glyceryl trinitrate (GTN), in the therapy of chronic anal fissure. MATERIALS AND METHODS:The patients were randomly assigned to three groups: 0.1% ISMN gel (21 patients), 0.1% GTN gel (21 ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00384-008-0632-8

    authors： Tankova L,Yoncheva K,Kovatchki D,Doytchinova I

    更新日期：2009-04-01 00:00:00

  • Adenocarcinoma of the ileoanal pouch for ulcerative colitis--a complication of severe chronic atrophic pouchitis?

    abstract：BACKGROUND:The appearance of a carcinoma in the ileal pouch after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative proctocolitis is rare. Most of these adenocarcinomas previously described in literature develop from residual viable rectal mucosa. We report a case of an adenocarcinoma ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-005-0063-8

    authors： Knupper N,Straub E,Terpe HJ,Vestweber KH

    更新日期：2006-07-01 00:00:00

  • High tie of the inferior mesenteric artery in distal colorectal resections--a safe vascular procedure.

    abstract：:Division of the inferior mesenteric artery flush with the aorta (high tie) allows a tension-free anastomosis in distal colorectal resections but may also diminish the blood supply. Tissue oxygen tension was measured proximal to the resection margin before and after either low or high division of the inferior mesenteri...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/BF00337583

    authors： Hall NR,Finan PJ,Stephenson BM,Lowndes RH,Young HL

    更新日期：1995-01-01 00:00:00

  • Prognostic impact of intrahepatic lymphatic and microvascular involvement in cases of colorectal liver metastases.

    abstract：OBJECTIVE:The purpose of this study was to evaluate the effect of intrahepatic microvascular and lymphatic infiltration on survival in cases of colorectal liver metastases. MATERIALS AND METHODS:Prospectively collected data of 331 patients were analyzed for microvascular invasion (V), lymphatic infiltration (L), and r...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00384-009-0674-6

    authors： Bockhorn M,Sotiropoulos G,Neuhaus J,Sgourakis G,Sheu SY,Molmenti E,Fingas C,Trarbach T,Frilling A,Broelsch CE

    更新日期：2009-07-01 00:00:00

  • Sexual and urinary functioning after rectal surgery: a prospective comparative study with a median follow-up of 8.5 years.

    abstract：PURPOSE:The purpose of this study was to prospectively compare rectal resection (RR) with colonic resection on sexual, urinary and bowel function and quality of life in both short-term and long-term. METHODS:Eighty-three patients who underwent RR were compared to 53 patients who underwent a colonic resection leaving t...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-011-1288-3

    authors： Doeksen A,Gooszen JA,van Duijvendijk P,Tanis PJ,Bakx R,Slors JF,van Lanschot JJ

    更新日期：2011-12-01 00:00:00

  • Hartmann's procedure in rectal cancer: a population-based study of postoperative complications.

    abstract：PURPOSE:Hartmann's procedure for rectal cancer patients is increasingly performed but few studies have reported the postoperative outcome. The purpose was to report postoperative complications and analyse risk factors in rectal cancer patients operated with Hartmann's procedure. To describe the selection and postoperat...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-014-2069-6

    authors： Sverrisson I,Nikberg M,Chabok A,Smedh K

    更新日期：2015-02-01 00:00:00

  • Evaluation of selective defunctioning stoma after low anterior resection for rectal cancer.

    abstract：BACKGROUND:Anastomotic leakage is a major concern after resection for low rectal cancer. Therefore, the use of a defunctioning stoma (DS) has been suggested, but limited data exist to clearly determine the necessity of a routine diversion. In our department, the indication of DS was evaluated subjectively by the operat...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-007-0380-1

    authors： Lefebure B,Tuech JJ,Bridoux V,Costaglioli B,Scotte M,Teniere P,Michot F

    更新日期：2008-03-01 00:00:00

  • Left-sided location is a risk factor for lymph node metastasis of T1 colorectal cancer: a single-center retrospective study.

    abstract：PURPOSE:Although some studies have reported differences in clinicopathological features between left- and right-sided advanced colorectal cancer (CRC), there are few reports regarding early-stage disease. In this study, we aimed to compare the clinicopathological features of left- and right-sided T1 CRC. METHODS:Subje...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-020-03668-x

    authors： Mochizuki K,Kudo SE,Ichimasa K,Kouyama Y,Matsudaira S,Takashina Y,Maeda Y,Ishigaki T,Nakamura H,Toyoshima N,Mori Y,Misawa M,Ogata N,Kudo T,Hayashi T,Wakamura K,Sawada N,Ishida F,Miyachi H

    更新日期：2020-10-01 00:00:00

  • Study of histopathologic parameters to define the prognosis of stage II colon cancer.

    abstract：PURPOSE:Stage II colon cancer (CC) represents a challenging scenario for the choice of adjuvant chemotherapy; here, histologic factors need to be weighed up to establish the risk of recurrence. Tumor budding (TB) has recently been indicated as a confident predictor of clinical outcome in CC. Likewise, the presence of p...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-019-03279-1

    authors： Romiti A,Roberto M,Marchetti P,Di Cerbo A,Falcone R,Campisi G,Ferri M,Balducci G,Ramacciato G,Ruco L,Pilozzi E

    更新日期：2019-05-01 00:00:00

  • Peritoneal fluid biomarkers in the detection of colorectal anastomotic leaks: a systematic review.

    abstract：PURPOSE:Anastomotic leak (AL) in colorectal surgery leads to significant morbidity, mortality and poorer oncological outcomes. Diagnosis of AL is frequently delayed as current methods of detection are not 100% sensitive or specific. 'Biomarkers', such as cytokines and markers of ischaemia, from the milieu of the anasto...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00384-017-2799-3

    authors： Wright EC,Connolly P,Vella M,Moug S

    更新日期：2017-07-01 00:00:00

  • Ileocolonic anastomosis after right hemicolectomy for carcinoma: stapled or hand-sewn? A prospective, multicenter, randomized trial.

    abstract：:440 patients were prospectively enrolled in a randomized, multicenter trial to compare 4 types of manual (84 interrupted end-to-end, 77 continuous end-to-end, 82 interrupted end-to-side, and 91 continuous end-to-side) (polyglycolic derived suture) and 1 type of stapled (106 side-to-side with GIA+TA devices) ileocoloni...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF00341273

    authors： Kracht M,Hay JM,Fagniez PL,Fingerhut A

    更新日期：1993-03-01 00:00:00

  • Implantation of tissue expander prior to irradiation in the era of intensity modulated radiotherapy: impact on the management of patients with pelvic digestive cancers.

    abstract：PURPOSE:Before the introduction of intensity-modulated radiation therapy (IMRT), few teams used to implant a pelvic tissue expander to keep the bowel away from the radiation field, so as to reduce the risk of acute and late enteritis. However, this unexpected surgery could impact patient's overall treatment and may be ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-019-03475-z

    authors： Ollivier L,Guilloit JM,Dos Santos M,Guillemette L,Florescu C,M'vondo CM,Meyer E,Galais MP,Corbinais S,Parzy A,Varatharajah S,Lesueur P

    更新日期：2020-03-01 00:00:00

  • Comparison of immunologic outcomes of laparoscopic vs open approaches in clinical stage III colorectal cancer.

    abstract：PURPOSE:Improved survival in patients with stage III colon cancer after a laparoscopic colectomy (LC) has been reported by Lacy et al. (Lancet 359:2224-2229, 6), and preserved immunity was suggested as the reason for the survival advantage. The aim of our study was to clarify the existence of an immunological benefit a...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00384-010-0882-0

    authors： Han SA,Lee WY,Park CM,Yun SH,Chun HK

    更新日期：2010-05-01 00:00:00

  • Extended mesenteric excision in right hemicolectomy for carcinoma of the colon.

    abstract：:Between 1979 and 1989, 169 patients had a curative operation for right sided colonic cancer. A retrospective analysis of the incidence and degree of lymph node metastasis was performed in all and survival rate was determined in 144 patients who could be followed over a period of 5 years or more. In all patients, disse...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s003840050104

    authors： Tagliacozzo S,Tocchi A

    更新日期：1997-01-01 00:00:00

  • Comparison of the erectile function in male patients with rectal cancer treated by preoperative radiotherapy followed by surgery and surgery alone.

    abstract：PURPOSE:This study evaluates the erectile function of male patients treated by preoperative radiotherapy followed by surgery and surgery alone for locally advanced rectal cancer. METHODS:A total of 112 men treated by total mesorectal excision with autonomic nerve preservation were included. Seventy-three patients were...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-010-0879-8

    authors： Song PH,Yun SM,Kim JH,Moon KH

    更新日期：2010-05-01 00:00:00

  • Effect of laparoscopic and conventional colorectal resection on peritoneal fibrinolytic capacity: a prospective randomized clinical trial.

    abstract：BACKGROUND AND AIMS:Reduced fibrinolytic activity of the peritoneum seems to be the main cause of postoperative adhesions. This prospective randomized trial compared the peritoneal fibrinolytic activity between laparoscopic and conventional colorectal resection. METHODS:Parietal peritoneal biopsy specimens were taken ...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00384-002-0391-x

    authors： Neudecker J,Junghans T,Ziemer S,Raue W,Schwenk W

    更新日期：2002-11-01 00:00:00

  • Laparoscopic adult colorectal surgeon and adolescents with inflammatory bowel disease: a safe combination?

    abstract：INTRODUCTION:A multidisciplinary tertiary service for adolescents with inflammatory bowel disease (IBD) was commenced in April 2008, aiming to provide specialist treatment for adolescent patients and bridge the gap between existing paediatric and adult surgical services. A single laparoscopic colorectal surgeon who nor...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00384-010-1058-7

    authors： Courtney ED,Brennan M,Noble-Jamieson G,Heuschkel R,Davies RJ

    更新日期：2011-03-01 00:00:00

  • Adjuvant perioperative portal vein or peripheral intravenous chemotherapy for potentially curative colorectal cancer: long-term results of a randomized controlled trial.

    abstract：BACKGROUND AND AIMS:The perioperative use of a single course adjuvant portal vein infusion chemotherapy in patients with potentially curable colorectal cancer has been shown to significantly improve overall survival but did not reduce the occurrence of liver metastases (SAKK 40/81) [Swiss Group for Clinical Cancer Rese...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00384-008-0543-8

    authors： Laffer U,Metzger U,Aeberhard P,Lorenz M,Harder F,Maibach R,Zuber M,Herrmann R

    更新日期：2008-12-01 00:00:00

  • The frequency of early colorectal cancer derived from sessile serrated adenoma/polyps among 1858 serrated polyps from a single institution.

    abstract：BACKGROUND AND AIM:Sessile serrated adenoma/polyps (SSAPs) are suspected to have a high malignant potential, although few reports have evaluated the incidence of carcinomas derived from SSAPs using the new classification for serrated polyps (SPs). The aim of study was to compare the frequency of cancer coexisting with ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-015-2416-2

    authors： Chino A,Yamamoto N,Kato Y,Morishige K,Ishikawa H,Kishihara T,Fujisaki J,Ishikawa Y,Tamegai Y,Igarashi M

    更新日期：2016-02-01 00:00:00

  • The prevention of colorectal anastomotic leakage with tissue adhesives in a contaminated environment is associated with the presence of anti-inflammatory macrophages.

    abstract：BACKGROUND:Colorectal anastomoses created in a contaminated environment result in a high leakage rate. This study investigated whether using anastomotic sealants (TissuCol(®), Histoacryl(®) Flex, and Duraseal(®)) prevents leakage in a rat peritonitis model. STUDY DESIGN:Sixty-seven Wistar rats were divided into contro...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-014-2012-x

    authors： Wu Z,Vakalopoulos KA,Boersema GS,Kroese LF,Lam KH,van der Horst PH,Mulder IM,Bastiaansen-Jenniskens YM,Kleinrensink GJ,Jeekel J,Lange JF

    更新日期：2014-12-01 00:00:00

  • Meta-analysis of randomized clinical trials comparing drainage alone vs primary sphincter-cutting procedures for anorectal abscess-fistula.

    abstract：BACKGROUND AND AIM:Concurrent definitive treatment of underlying fistulas from infected anal glands at the time when the anorectal abscesses are drained is controversial as this is associated with a higher incidence of faecal incontinence, failure and recurrence. This meta-analysis was conducted to determine the merits...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00384-005-0060-y

    authors： Quah HM,Tang CL,Eu KW,Chan SY,Samuel M

    更新日期：2006-09-01 00:00:00

  • Disease severity and treatment requirements in familial inflammatory bowel disease.

    abstract：PURPOSE:Several studies demonstrate an increased prevalence and concordance of inflammatory bowel disease among the relatives of patients. Other studies suggest that genetic influence is over-estimated. The aims of this study are to evaluate the phenotypic expression and the treatment requirements in familial inflammat...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-017-2791-y

    authors： Ballester MP,Martí D,Tosca J,Bosca-Watts MM,Sanahuja A,Navarro P,Pascual I,Antón R,Mora F,Mínguez M

    更新日期：2017-08-01 00:00:00