Comparison of immunologic outcomes of laparoscopic vs open approaches in clinical stage III colorectal cancer.

Abstract:

PURPOSE:Improved survival in patients with stage III colon cancer after a laparoscopic colectomy (LC) has been reported by Lacy et al. (Lancet 359:2224-2229, 6), and preserved immunity was suggested as the reason for the survival advantage. The aim of our study was to clarify the existence of an immunological benefit after laparoscopic colon cancer surgery (LC) compared to open colon surgery (OC). METHODS:From January 2006 to November 2007, 74 patients with clinical stage III colon cancer were prospectively assigned to undergo a LC (n = 35) or an OC (n = 39). The immune factors were examined preoperatively, and on the first and fifth days postoperatively (POD1 and POD5). RESULTS:The cellular immune factors were significantly decreased; however, there was no significant difference between the LC and OC groups except for the mHLA-DR. The LC group had a better preserved mHLA-DR on POD5 than did the OC group (p = 0.015), in addition to a faster recovery (p < 0.005). CONCLUSION:The mHLA-DR on POD5 was affected less by the LC compared to the OC. The LC demonstrated minimal immunological advantage when compared to the OC. However, further study is required to clarify the immunological benefits of the LC on colorectal cancer prognosis.

journal_name

Int J Colorectal Dis

authors

Han SA,Lee WY,Park CM,Yun SH,Chun HK

doi

10.1007/s00384-010-0882-0

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

631-8

issue

5

eissn

0179-1958

issn

1432-1262

journal_volume

25

pub_type

临床试验,杂志文章
  • Function of the striated anal sphincter during straining in control subjects and constipated patients with a radiologically normal rectum or idiopathic megacolon.

    abstract::The function of the striated anal sphincter during defaecation straining was recorded by manometry and electromyography (E.M.G.) in 31 constipated patients who were unable to expel a water-filled rectal balloon with effort. This group was divided on the basis of measurement of colonic diameter into those with megacolo...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF01660715

    authors: Barnes PR,Lennard-Jones JE

    更新日期:1988-11-01 00:00:00

  • Treating symptomatic adhesions to the sigmoid colon: colectomy improves quality of life.

    abstract:INTRODUCTION:When severe chronic pelvic pain, constipation, and bloating are due to dense pelvic adhesions fixing the sigmoid loops, patients may be offered the option of sigmoid colectomy. This study examines the effectiveness of colectomy in the treatment of such patients. METHODS:Patients were identified from a sur...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-013-1711-z

    authors: Jarrar A,Church J

    更新日期:2013-10-01 00:00:00

  • Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer.

    abstract:BACKGROUND:Preclinical and clinical evidence support an association between vitamin D deficiency and an increased risk of colorectal cancer. Normal vitamin D status has been linked to favorable health outcomes ranging from decreased risk of osteoporosis to improved cancer mortality. We performed a retrospective study t...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-008-0593-y

    authors: Fakih MG,Trump DL,Johnson CS,Tian L,Muindi J,Sunga AY

    更新日期:2009-02-01 00:00:00

  • Factors affecting lymph node yield from patients undergoing colectomy for cancer.

    abstract:PURPOSE:Lymph node (LN) yield is a critical component of colon cancer staging and is often a surrogate for quality assessment in surgery. We investigated the impact of pathologists' training on LN harvest. METHODS:This is a retrospective review on 137 patients undergoing elective colectomy for adenocarcinoma at a sing...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-011-1240-6

    authors: Bamboat ZM,Deperalta D,Dursun A,Berger DL,Bordeianou L

    更新日期:2011-09-01 00:00:00

  • Effect of ulcerative colitis duration on the usefulness of immunochemical fecal occult blood test result as a disease activity biomarker.

    abstract:PURPOSE:The effects of ulcerative colitis (UC) duration on biomarker accuracy are unknown. We investigated the effects of UC duration on the predictive accuracy of biomarkers including immunochemical fecal occult blood test (FOBT, also known as FIT), prostaglandin E-major urinary metabolite (PGE-MUM), and C-reactive pr...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03636-5

    authors: Ishida N,Miyazu T,Matsuura T,Takano R,Tamura S,Kagami T,Tani S,Yamade M,Hamaya Y,Iwaizumi M,Osawa S,Furuta T,Sugimoto K

    更新日期:2020-09-01 00:00:00

  • Risk of lymph node metastasis after endoscopic treatment for rectal NETs 10 mm or less.

    abstract:PURPOSE:For rectal neuroendocrine tumors (NETs) ≤ 10 mm, endoscopic resection is a standard treatment. However, there is no consensus whether additional surgery should be performed for patients at risk of lymph node metastasis (LNM) after endoscopic resection. The purpose of this study was to analyze the results of end...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03826-1

    authors: Inada Y,Yoshida N,Fukumoto K,Hirose R,Inoue K,Dohi O,Murakami T,Ogiso K,Tomie A,Kugai M,Yoriki H,Inagaki Y,Hasegawa D,Okuda K,Okuda T,Morinaga Y,Kishimoto M,Itoh Y

    更新日期:2021-01-02 00:00:00

  • Extent of surgery and recurrence rate of hidradenitis suppurativa.

    abstract::Hidradenitis suppurativa (HS) is a chronic fistula- and abscess-forming disease of the cutis and subcutis of unknown etiology. Disease recurrence is frequent and may cause severe complications. We analyzed patients with HS who underwent surgery between 1976 and 1997. The operative procedures were divided into drainage...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840050159

    authors: Ritz JP,Runkel N,Haier J,Buhr HJ

    更新日期:1998-01-01 00:00:00

  • Mesenteric fibromatosis.

    abstract::Mesenteric fibromatosis is a rare, locally invasive, non-metastasizing type of intra-abdominal fibromatoses with a very high rate of recurrence. Because of rarity, these tumors pose a diagnostic and therapeutic challenge. These tumors may remain asymptomatic, but commonly present as a painless mass. There are no clear...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-014-1995-7

    authors: Chaudhary P

    更新日期:2014-12-01 00:00:00

  • Anti-p53 autoantibody in colorectal cancer: prognostic significance in long-term follow-up.

    abstract:BACKGROUND:The prognostic significance of anti-53 autoantibody in colorectal cancer (CRC) patients is unclear due to measurement of overall rather than disease-specific survival and generally short follow-up periods in many studies. We aim to investigate prognostic significance of anti-p53 auto-antibodies in a study wi...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-008-0458-4

    authors: Suppiah A,Alabi A,Madden L,Hartley JE,Monson JR,Greenman J

    更新日期:2008-06-01 00:00:00

  • Reduction of miss rates of colonic adenomas by zoom chromoendoscopy.

    abstract:BACKGROUND AND AIMS:The aim of this study was to determine the detection rate of polyps using zoom chromoendoscopy (ZE) compared with standard video colonoscopy. PATIENTS AND METHODS:End-to-end colonoscopies were performed in 50 patients by two different endoscopists blinded for each other's results. Lesions detected ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-005-0052-y

    authors: Stergiou N,Frenz MB,Menke D,Riphaus A,Wehrmann T

    更新日期:2006-09-01 00:00:00

  • The factors influencing long-term outcomes of stenting for malignant colorectal obstruction in elderly group in community medicine.

    abstract:PURPOSE:Malignant bowel obstruction is a complication of colorectal carcinoma or metastasis from other carcinoma, and it causes significant damage on the condition of elderly patients; however, the self-expandable metallic stents (SEMSs) have been effectively used either for palliation or for bridging to the surgical p...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-017-2946-x

    authors: Imai M,Kamimura K,Takahashi Y,Sato T,Isokawa O,Maruyama M,Kobayashi T,Hayashi K,Terai S

    更新日期:2018-02-01 00:00:00

  • A single institution's long-term follow-up of patients with pathological complete response in locally advanced rectal adenocarcinoma following neoadjuvant chemoradiotherapy.

    abstract:PURPOSE:This paper aimed to study the long term follow-up of patients with primary rectal adenocarcinoma receiving neoadjuvant chemoradiotherapy who obtained a pathological complete response (pCR) and identify factors predicting complete response. METHODS:Retrospective review of notes, histology, pre-operative full bl...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2712-5

    authors: Runau F,Collins A,Fenech GA,Ford E,Dimitriou N,Chaudhri S,Yeung JM

    更新日期:2017-03-01 00:00:00

  • Utility of a three-dimensional printed pelvic model for lateral pelvic lymph node dissection.

    abstract:PURPOSE:In patients with advanced lower rectal cancer, the complex pelvic anatomy renders lateral pelvic lymph node dissection to be challenging. Therefore, we evaluated the utility of printing a three-dimensional (3D) pelvic model for lateral pelvic lymph node dissection. METHODS:We included 22 patients who underwent...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03534-w

    authors: Hojo D,Murono K,Nozawa H,Kawai K,Hata K,Tanaka T,Ishihara S

    更新日期:2020-05-01 00:00:00

  • Ambulatory versus conventional laparoscopic appendectomy: a systematic review and meta-analysis.

    abstract:PURPOSE:Ambulatory laparoscopic appendectomy has gained popularity due to the improved understanding of patient selection criteria, the application of enhanced recovery pathways, and the potential for improving healthcare resource utilization. The aim of the review was to compare the morbidity and readmission rates bet...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00384-019-03341-y

    authors: Trejo-Avila M,Cárdenas-Lailson E,Valenzuela-Salazar C,Herrera-Esquivel J,Moreno-Portillo M

    更新日期:2019-08-01 00:00:00

  • Topical anal fissure treatment: placebo-controlled study of mononitrate and trinitrate therapies.

    abstract:AIM:The present study aims to evaluate and compare the efficacy of two nitrate gels, containing isosorbide-5-mononitrate (ISMN) or glyceryl trinitrate (GTN), in the therapy of chronic anal fissure. MATERIALS AND METHODS:The patients were randomly assigned to three groups: 0.1% ISMN gel (21 patients), 0.1% GTN gel (21 ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00384-008-0632-8

    authors: Tankova L,Yoncheva K,Kovatchki D,Doytchinova I

    更新日期:2009-04-01 00:00:00

  • Psychological stress in patients with anal fistula.

    abstract:AIM:Psychological stress is known to affect the immunologic system and the inflammatory response. The aim of this study was to assess the presence of psychological stress, anxiety, and depression in patients with anal fistula. METHODS:Consecutive patients with anal fistula, hemorrhoids, and normal volunteers were stud...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-015-2245-3

    authors: Cioli VM,Gagliardi G,Pescatori M

    更新日期:2015-08-01 00:00:00

  • Evaluation of four comorbidity indices and Charlson comorbidity index adjustment for colorectal cancer patients.

    abstract:INTRODUCTION:Cancer survival is related not only to primary malignancy but also to concomitant nonmalignant diseases. The aim of this study was to investigate the prognostic capacity of four comorbidity indices [the Charlson comorbidity index (CCI), the Elixhauser method, the National Institute on Aging (NIA) and Natio...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-014-1972-1

    authors: Marventano S,Grosso G,Mistretta A,Bogusz-Czerniewicz M,Ferranti R,Nolfo F,Giorgianni G,Rametta S,Drago F,Basile F,Biondi A

    更新日期:2014-09-01 00:00:00

  • Association between serum bilirubin and mucosal healing among Japanese patients with ulcerative colitis: a cross-sectional study.

    abstract:PURPOSE:Bilirubin is known to have antioxidant effects. Several pieces of evidence regarding association between serum bilirubin and UC exist. Three studies found that serum bilirubin was inversely associated with severity of ulcerative colitis (UC), but no evidence regarding an association between serum bilirubin and ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03774-w

    authors: Shiraishi K,Furukawa S,Yagi S,Hanayama M,Mori K,Ninomiya T,Suzuki S,Ohashi K,Murakami H,Takeshita E,Ikeda Y,Hiasa Y

    更新日期:2021-02-01 00:00:00

  • Solo operated haemorrhoid ligator rectoscope. A report on 200 consecutive bandings.

    abstract::A new solo operated haemorrhoid ligator rectoscope is described by the author. This new ligator consists of a double barreled cone, one fitting precisely inside the other. The device functions as a rectoscope to visualize the wall of the ano-rectum and at the same time the distal end of the interior barrel carries the...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840050077

    authors: Budding J

    更新日期:1997-01-01 00:00:00

  • Colonic transit time in mentally retarded persons.

    abstract:INTRODUCTION:Constipation is frequently seen in patients with mental retardation (MR). Its pathophysiology is poorly understood. Measurement of colon transit time (CTT) differentiates between retentive and non-retentive constipation. AIM:To determine total and segmental CTT in MR patients compared to healthy controls....

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00384-010-0928-3

    authors: Vande Velde S,Van Biervliet S,Van Goethem G,De Looze D,Van Winckel M

    更新日期:2010-07-01 00:00:00

  • Usefulness of anorectal and endovaginal 3D ultrasound in the evaluation of sphincter and pubovisceral muscle defects using a new scoring system in women with fecal incontinence after vaginal delivery.

    abstract:PURPOSE:This study aims to evaluate pubovisceral muscle and anal sphincter defects in women with previous vaginal delivery and fecal incontinence and to correlate the findings with the severity of symptoms using the combined anorectal and endovaginal 3D ultrasonography with a new ultrasound scoring system. METHODS:Con...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2750-z

    authors: Murad-Regadas SM,da S Fernandes GO,Regadas FS,Rodrigues LV,Filho FS,Dealcanfreitas ID,da Silva Vilarinho A,da Cruz MM

    更新日期:2017-04-01 00:00:00

  • Erectile and urinary function in men with rectal cancer treated by neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy alone: a randomized trial report.

    abstract:OBJECTIVE:The aim was to evaluate erectile and urinary function of male patients with rectal cancer treated by neoadjuvant (NA) chemoradiotherapy (CRT) or NA chemotherapy only. METHODS:In this prospective randomized trial (ClinicalTrials.gov NCT01211210; "FOWARC"), we included 102 men who received NA therapy for stage...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00384-016-2605-7

    authors: Huang M,Lin J,Yu X,Chen S,Kang L,Deng Y,Zheng J,Luo Y,Wang L,Lan P,Wang J

    更新日期:2016-07-01 00:00:00

  • Significance of hepatic arterial responsiveness for adequate tissue oxygenation upon portal vein occlusion in cirrhotic livers.

    abstract::We investigated sinusoidal blood flow and hepatic tissue oxygenation during portal vein occlusion in cirrhotic rat livers to examine the effect of cirrhosis on the properties of hepatic microvascular blood flow regulation. After 8 weeks of CCl4/phenobarbital sodium treatment to induce cirrhosis Sprague-Dawley rats wer...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840000247

    authors: Mücke I,Richter S,Menger MD,Vollmar B

    更新日期:2000-11-01 00:00:00

  • (E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa.

    abstract:BACKGROUND:Nicotine is of therapeutic value in ulcerative colitis, but its administration is connected with adverse events. Nicotine derivatives are currently being tested to maintain the therapeutic effects and minimize adverse events. TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to dete...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-006-0135-4

    authors: Spoettl T,Paetzel C,Herfarth H,Bencherif M,Schoelmerich J,Greinwald R,Gatto GJ,Rogler G

    更新日期:2007-03-01 00:00:00

  • The use of infliximab in the prevention of postsurgical recurrence in polysurgery Crohn's disease patients: a pilot open-labeled prospective study.

    abstract:PURPOSE:Crohn's disease (CD) commonly recurs after surgery, and a number of patients need repeated surgery, especially smokers and those with repeated surgeries or penetrating disease. Whether infliximab prevents postsurgical recurrence in high-risk CD remains unknown. In the present pilot open-labeled study, we invest...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00384-011-1398-y

    authors: Sakuraba A,Sato T,Matsukawa H,Okamoto S,Takaishi H,Ogata H,Iwao Y,Hibi T

    更新日期:2012-07-01 00:00:00

  • Meta-analysis and trial sequential analysis of robotic versus laparoscopic total mesorectal excision in management of rectal cancer.

    abstract:BACKGROUND:We aimed to evaluate comparative outcomes of robotic and laparoscopic total mesorectal excision (TME) in patients with rectal cancer. METHODS:We systematically searched electronic data sources with application of combination of free text and controlled vocabulary search adapted to thesaurus headings, search...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-020-03655-2

    authors: Eltair M,Hajibandeh S,Hajibandeh S,Nuno A,Abdullah KH,Alkaili-Alyamani A,Aslam MI,Sinha A,Agarwal T

    更新日期:2020-08-01 00:00:00

  • Protective colostomy closure: the hazards of a "minor" operation.

    abstract::A retrospective study of 87 patients, subjected to colostomy closure between 1976 and 1987, was conducted in order to evaluate the role of 8 potential risk factors on morbidity and mortality. Possible risk factors were age greater than 65 years, presence of hypoalbuminaemia (less than 3.0 gr%), anaemia (Hb less than 1...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF00298472

    authors: Altomare DF,Pannarale OC,Lupo L,Palasciano N,Memeo V,Rubino M

    更新日期:1990-05-01 00:00:00

  • Comparison of the erectile function in male patients with rectal cancer treated by preoperative radiotherapy followed by surgery and surgery alone.

    abstract:PURPOSE:This study evaluates the erectile function of male patients treated by preoperative radiotherapy followed by surgery and surgery alone for locally advanced rectal cancer. METHODS:A total of 112 men treated by total mesorectal excision with autonomic nerve preservation were included. Seventy-three patients were...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-010-0879-8

    authors: Song PH,Yun SM,Kim JH,Moon KH

    更新日期:2010-05-01 00:00:00

  • Learning curve for robotic-assisted laparoscopic rectal cancer surgery.

    abstract:INTRODUCTION:One of the main uses of robotic assisted abdominal surgery is the mesorectal excision in patients with rectal cancer. The aim of the present study is to analyse the learning curve for robotic assisted laparoscopic resection of rectal cancer. PATIENTS AND METHODS:We included in our study 43 consecutive rec...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-012-1620-6

    authors: Jiménez-Rodríguez RM,Díaz-Pavón JM,de la Portilla de Juan F,Prendes-Sillero E,Dussort HC,Padillo J

    更新日期:2013-06-01 00:00:00

  • Transarterial embolization in acute colonic bleeding: review of 11 years of experience and long-term results.

    abstract:BACKGROUND:Lower gastrointestinal bleeding represents 20 % of all gastrointestinal bleedings. Interventional radiology has transformed the treatment of this pathology, but the long-term outcome after selective embolization has been poorly evaluated. The aim of this study is thus to evaluate the short-term and long-term...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-012-1621-5

    authors: Rossetti A,Buchs NC,Breguet R,Bucher P,Terraz S,Morel P

    更新日期:2013-06-01 00:00:00