The effects of fast-track surgery on inflammation and immunity in patients undergoing colorectal surgery.

Abstract:

OBJECTIVE:The objective of this study is to explore the effects of the fast-track surgery (FTS) program on inflammation and immunity in patients undergoing colorectal surgery. METHODS:From August 2014 to March 2015, a prospective and randomized controlled trial of 230 patients who underwent colorectal surgery was performed. The patients were randomly assigned to an FTS group (116 patients) or a traditional group (114 patients). Inflammatory mediators, immunological indicators, postoperative recovery indexes, and complications were compared between the two groups. RESULTS:The inflammatory mediators (CRP, IL-6, TNF-α) were lower in the FTS group than in the traditional group (P < 0.05) on postoperative day (POD) 1, POD 4, and POD 6, and the immunological indicators (IgG, IgA, C3, C4) of the FTS group were superior to those of the traditional group (P < 0.05) on POD 4 and POD 6. The time to first aerofluxus, defecation, oral intake, and ambulation after surgery was shorter in the FTS group than in the traditional group (P < 0.05); however, the duration of postoperative hospitalization did not differ significantly between the two groups (P > 0.05). The total complications were significantly lower in the FTS group than in the traditional group (P < 0.05). CONCLUSION:The FTS program can decrease inflammation, maintain immune homeostasis, and improve rehabilitation effects in colorectal surgery patients.

journal_name

Int J Colorectal Dis

authors

Feng J,Li K,Li L,Wang X,Huang M,Yang J,Hu Y

doi

10.1007/s00384-016-2630-6

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

1675-82

issue

10

eissn

0179-1958

issn

1432-1262

pii

10.1007/s00384-016-2630-6

journal_volume

31

pub_type

杂志文章,随机对照试验
  • Role of CT colonography in symptomatic assessment, surveillance and screening.

    abstract:INTRODUCTION:When 'whole colonic imaging' is indicated, clinicians must decide between optical colonoscopy, barium enema and CT colonography (CTC). CTC is a relatively new technique which has become increasingly accessible in the UK over the past 5 years. As radiologists have gained experience and scanning parameters h...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-011-1178-8

    authors: Almond LM,Bowley DM,Karandikar SS,Roy-Choudhury SH

    更新日期:2011-08-01 00:00:00

  • Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue.

    abstract:BACKGROUND AND AIMS:Malignant cells often exhibit perturbations in the pattern of cytosine methylation. Hypermethylation of CpG islands has been extensively documented, but genome-wide hypomethylation is also a common feature of malignant cells. The bulk of cytosine methylation in the mammalian genome occurs on repetit...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-003-0539-3

    authors: Suter CM,Martin DI,Ward RL

    更新日期:2004-03-01 00:00:00

  • Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancer.

    abstract:BACKGROUND AND AIMS:The prognostic value of the degree of apoptosis in colorectal cancer is controversial. This study evaluates the putative clinical usefulness of measuring caspase-3 activity as a prognostic factor in colonic cancer patients receiving 5-fluoracil adjuvant chemotherapy. MATERIALS AND METHODS:We evalua...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-007-0362-3

    authors: de Oca J,Azuara D,Sanchez-Santos R,Navarro M,Capella G,Moreno V,Sola A,Hotter G,Biondo S,Osorio A,Martí-Ragué J,Rafecas A

    更新日期:2008-01-01 00:00:00

  • Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy.

    abstract:BACKGROUND AND AIMS:Rectovaginal fistulas in patients with Crohn's disease are difficult to resolve, and surgical failure is very frequent. Recent studies have shown that adult stem cells extracted from certain tissues, such as adipose tissue, can develop into different tissues, such as muscle. PATIENT AND METHODS:We ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-003-0490-3

    authors: García-Olmo D,García-Arranz M,García LG,Cuellar ES,Blanco IF,Prianes LA,Montes JA,Pinto FL,Marcos DH,García-Sancho L

    更新日期:2003-09-01 00:00:00

  • Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats.

    abstract:OBJECTIVE/BACKGROUND:Signals for the expression of the peptide growth factors epidermal growth factor and transforming growth factor-alpha (TGFalpha) in the gastrointestinal mucosa are largely unknown. We have shown earlier that extrinsic afferents in the gastrointestinal tract induce TGFalpha expression in colonic muc...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-009-0856-2

    authors: Bulut K,Felderbauer P,Hoeck K,Schmidt WE,Hoffmann P

    更新日期:2010-03-01 00:00:00

  • Extralevator versus standard abdominoperineal excision in locally advanced rectal cancer: a retrospective study with long-term follow-up.

    abstract:PURPOSE:To analyze the results of abdominoperineal excisions (APE) for locally advanced rectal cancer at our institution before and after the adoption of extralevator abdominoperineal excision (ELAPE) with a special reference to long-term survival. METHODS:A retrospective cohort study conducted in a tertiary referral ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-2977-y

    authors: Carpelan A,Karvonen J,Varpe P,Rantala A,Kaljonen A,Grönroos J,Huhtinen H

    更新日期:2018-04-01 00:00:00

  • Randomized clinical trial comparing simple drainage of anorectal abscess with and without fistula track treatment.

    abstract:BACKGROUND AND AIMS:Anal abscess is a frequent acute proctological disorder and whether the underlying fistula should be treated at the same time when the abscess is drained remains controversial. We examined indications for drainage alone versus drainage plus fistulotomy in terms of recurrence and continence. PATIENT...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00384-002-0429-0

    authors: Oliver I,Lacueva FJ,Pérez Vicente F,Arroyo A,Ferrer R,Cansado P,Candela F,Calpena R

    更新日期:2003-03-01 00:00:00

  • Emergency subtotal/total colectomy in the management of obstructed left colon carcinoma.

    abstract:PURPOSE:The treatment of acutely obstructed carcinoma of the left colon still represents a matter of controversy. The aim of the study was to evaluate the results of its management by emergency subtotal or total colectomy with immediate anastomosis without diversion. METHODS:An emergency subtotal/total colectomy was p...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-005-0048-7

    authors: Hennekinne-Mucci S,Tuech JJ,Bréhant O,Lermite E,Bergamaschi R,Pessaux P,Arnaud JP

    更新日期:2006-09-01 00:00:00

  • Transureteroureterostomy: an adjunct to the management of advanced primary and recurrent pelvic malignancy.

    abstract:BACKGROUND AND AIMS:The surgical management of advanced primary or recurrent rectal cancer may involve the lower ureter or ureterovesical junction. With unilateral involvement, reconstruction of the ureters with salvage of the ipsilateral renal function should be considered. PATIENTS AND METHODS:With optimal exposure ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-002-0399-2

    authors: Sugarbaker PH,Gutman M,Verghese M

    更新日期:2003-01-01 00:00:00

  • Strictureplasty for active Crohn's disease.

    abstract:BACKGROUND AND AIMS:Several studies over the last 20 years have confirmed the safety and efficacy of strictureplasty in the treatment of obstructive Crohn's disease. However, almost all of these studies use strictureplasty to treat fibrotic strictures: limited resection being preferred to treat active disease stricture...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-005-0029-x

    authors: Roy P,Kumar D

    更新日期:2006-07-01 00:00:00

  • Abnormal expression of E-cadherin, beta-catenin, and c-erbB-2 in advanced gastric cancer: its association with liver metastasis.

    abstract:BACKGROUND AND AIMS:We investigated expression of E-cadherin, beta-catenin, and c-erbB-2 in gastric cancer to identify molecular factor(s) relevant to development of liver metastasis, which is a frequent cause of mortality in gastric cancer patients. PATIENTS AND METHODS:We analyzed by immunohistochemistry and compare...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-002-0427-2

    authors: Ougolkov A,Yamashita K,Bilim V,Takahashi Y,Mai M,Minamoto T

    更新日期:2003-03-01 00:00:00

  • Meta-analysis and trial sequential analysis of robotic versus laparoscopic total mesorectal excision in management of rectal cancer.

    abstract:BACKGROUND:We aimed to evaluate comparative outcomes of robotic and laparoscopic total mesorectal excision (TME) in patients with rectal cancer. METHODS:We systematically searched electronic data sources with application of combination of free text and controlled vocabulary search adapted to thesaurus headings, search...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-020-03655-2

    authors: Eltair M,Hajibandeh S,Hajibandeh S,Nuno A,Abdullah KH,Alkaili-Alyamani A,Aslam MI,Sinha A,Agarwal T

    更新日期:2020-08-01 00:00:00

  • The prognostic and clinicopathological value of tumor-associated macrophages in patients with colorectal cancer: a systematic review and meta-analysis.

    abstract:PURPOSE:There is a growing literature on the significance of tumor-associated macrophages (TAMs) in colorectal cancer (CRC). However, the role of TAMs in predicting the prognosis of CRC remains controversial. The current study aims to determine the prognostic and clinicopathological value of different types and distrib...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-020-03686-9

    authors: Yang Z,Zhang M,Peng R,Liu J,Wang F,Li Y,Zhao Q,Liu J

    更新日期:2020-09-01 00:00:00

  • Single-dose metronidazole versus 5-day multi-drug antibiotic regimen in excision of pilonidal sinuses with primary closure: a prospective randomised controlled double-blinded study.

    abstract:BACKGROUND AND AIMS:This pilot study examines whether single-dose intravenous metronidazole preoperatively is at least as effective as a broad-spectrum multi-drug regimen in preventing infection-related wound complications following excision of pilonidal sinuses with primary closure. PATIENTS AND METHODS:A double-blin...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00384-002-0416-5

    authors: Chaudhuri A,Bekdash BA

    更新日期:2002-09-01 00:00:00

  • New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms.

    abstract:PURPOSE:Sound speed correction (SSC) is a non-invasive modality that quantifies the hardness of neoplasms. The aim of our study was to evaluate the usefulness of SSC for the diagnostic accuracy of colorectal neoplasms and to differentiate the depth of invasion. METHODS:Forty colorectal neoplasms, contributed by 40 pat...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03790-w

    authors: Esaki M,Yamamura T,Nakamura M,Maeda K,Sawada T,Mizutani Y,Ishikawa E,Furukawa K,Kawashima H,Hirooka Y,Fujishiro M

    更新日期:2020-10-28 00:00:00

  • Microvascular blood flow response in the intestinal wall and the omentum during negative wound pressure therapy of the open abdomen.

    abstract:PURPOSE:Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) compared with other wound therapy techniques. However, the method has occasionally been associated with increased development of intestinal fistulae. The present study measures microvascular blood flow in the...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-011-1317-2

    authors: Hlebowicz J,Hansson J,Lindstedt S

    更新日期:2012-03-01 00:00:00

  • Placement of SurgiWrap® adhesion barrier film around the protective loop stoma after laparoscopic colorectal cancer surgery may reduce the peristomal adhesion severity and facilitate the closure.

    abstract:PURPOSE:A temporary loop stoma is often created after laparoscopic colorectal cancer surgery. Peristomal adhesions may make stoma closure into a complicated operation. We demonstrated how to place the SurgiWrap® adhesion barrier film and evaluated the peristomal adhesion severity and feasibility of stoma closure. METH...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-03229-3

    authors: Hsu CW,Chang MC,Wang JH,Wu CC,Chen YH

    更新日期:2019-03-01 00:00:00

  • Diverting loop ileostomy with colonic lavage as an alternative to colectomy for fulminant Clostridioides difficile: a systematic review and meta-analysis.

    abstract:PURPOSE:Surgical consultation is recommended for all patients with fulminant Clostridioides difficile infection (CDI). If surgery is required, total abdominal colectomy (TAC) is most commonly performed. However, diverting loop ileostomy and colonic lavage have been recently developed as a potential colon-sparing approa...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00384-019-03447-3

    authors: McKechnie T,Lee Y,Springer JE,Doumouras AG,Hong D,Eskicioglu C

    更新日期:2020-01-01 00:00:00

  • Significance of hepatic arterial responsiveness for adequate tissue oxygenation upon portal vein occlusion in cirrhotic livers.

    abstract::We investigated sinusoidal blood flow and hepatic tissue oxygenation during portal vein occlusion in cirrhotic rat livers to examine the effect of cirrhosis on the properties of hepatic microvascular blood flow regulation. After 8 weeks of CCl4/phenobarbital sodium treatment to induce cirrhosis Sprague-Dawley rats wer...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840000247

    authors: Mücke I,Richter S,Menger MD,Vollmar B

    更新日期:2000-11-01 00:00:00

  • Nomogram for predicting anastomotic leakage after low anterior resection for rectal cancer.

    abstract:PURPOSE:Anastomotic leakage after low anterior resection for rectal cancer is a critical problem. Many risk factors have been suggested and surgical techniques have improved, but anastomotic leakage remains a major postoperative challenge. This study sought to create a nomogram for precise prediction of anastomotic lea...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-2970-5

    authors: Hoshino N,Hida K,Sakai Y,Osada S,Idani H,Sato T,Takii Y,Bando H,Shiomi A,Saito N

    更新日期:2018-04-01 00:00:00

  • Interferon gamma downregulates IL-8 production in primary human colonic epithelial cells without induction of apoptosis.

    abstract:BACKGROUND:In acute or chronic inflammatory bowel disease (IBD) interferon gamma (IFNgamma) is still considered to be an important pro-inflammatory mediator. In the present study we investigated the impact of IFNgamma on interleukin-8 (IL-8) production as a read-out for cell activation in intestinal epithelial cell (IE...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-003-0570-4

    authors: Schlottmann K,Wachs FP,Grossmann J,Vogl D,Maendel M,Falk W,Schölmerich J,Andus T,Rogler G

    更新日期:2004-09-01 00:00:00

  • Comparison of inpatient and outpatient upper gastrointestinal haemorrhage.

    abstract:BACKGROUND AND AIMS:Inpatients developing upper gastrointestinal (GI) haemorrhage are at increased risk of death. This study was performed to elucidate differences in inpatients and outpatients. PATIENTS/METHODS:Three hundred and sixty-two patients who needed esophagogastroduodenoscopy for upper GI bleeding were ident...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-004-0642-0

    authors: Klebl FH,Bregenzer N,Schöfer L,Tamme W,Langgartner J,Schölmerich J,Messmann H

    更新日期:2005-07-01 00:00:00

  • Ileostomy adenocarcinoma in Crohn's disease.

    abstract:PURPOSE:Adenocarcinoma of an ileostomy is rare with less than 50 reported cases in the literature. Ileostomy adenocarcinoma in Crohn's disease is even more rare, with only 4 reported cases. We present a case of ileostomy adenocarcinoma with lymph node metastasis occurring 51 years after proctocolectomy and Brooke ileos...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03554-6

    authors: Yousaf A,Beatty C,Zinn Z,Cassim R,Gayam S

    更新日期:2020-05-01 00:00:00

  • New approach to large haemorrhoidal prolapse: double stapled haemorrhoidopexy.

    abstract:PURPOSE:To verify if in large haemorrhoidal prolapse (independently from the degree) in patients with no symptoms of obstructed defaecation syndrome, the use of a stapled hemorrhoidopexy variant, comprising a double stapler haemorrhoidopexy (DSH), makes it possible to reduce the percentage of failures or relapses and t...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-009-0750-y

    authors: Naldini G,Martellucci J,Talento P,Caviglia A,Moraldi L,Rossi M

    更新日期:2009-12-01 00:00:00

  • Preoperative anaemia and perioperative red blood cell transfusion as prognostic factors for recurrence and mortality in colorectal cancer-a Swedish cohort study.

    abstract:PURPOSE:The hypothesis in this study was that anaemia prior to surgery and perioperative red blood cell transfusion increases the risk for recurrence and overall mortality in patients with stages I-III colorectal cancer after abdominal resection with curative intent. METHODS:This is a Swedish single centre retrospecti...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2678-3

    authors: Mörner ME,Edgren G,Martling A,Gunnarsson U,Egenvall M

    更新日期:2017-02-01 00:00:00

  • Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study.

    abstract::In hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, more than 90% of the carcinomas show microsatellite instability (MSI) due to a loss of mismatch repair (MMR) function. Although adenomas are very common in HNPCC and demonstrate an accelerated adenoma-carcinoma sequence, data about the prevalence and devel...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-005-0073-6

    authors: German HNPCC Consortium.,Müller A,Beckmann C,Westphal G,Bocker Edmonston T,Friedrichs N,Dietmaier W,Brasch FE,Kloor M,Poremba C,Keller G,Aust DE,Fass J,Büttner R,Becker H,Rüschoff J

    更新日期:2006-10-01 00:00:00

  • Focus on current and future management possibilities in inflammatory bowel disease-related chronic pain.

    abstract:INTRODUCTION:Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this debilitating state has not been established. Chronic pain is one of the most important factors decreasing the quality of life in IBD course. Concurrently, management of pa...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-018-3218-0

    authors: Zielińska A,Sałaga M,Włodarczyk M,Fichna J

    更新日期:2019-02-01 00:00:00

  • The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence.

    abstract:OBJECTIVE:The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy. MATERIALS AND METHODS:Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer. RESULTS:The IGF system...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-005-0776-8

    authors: Davies M,Gupta S,Goldspink G,Winslet M

    更新日期:2006-04-01 00:00:00

  • Post-polypectomy surveillance colonoscopy: are we following the guidelines?

    abstract:PURPOSE:Polyps are a common finding on colonoscopy procedures. After completing polypectomy, patients are to be followed up with endoscopy. The purpose of the study was to assess the adherence of gastroenterologists to international post-polypectomy guidelines. METHODS:Israeli gastroenterologists answered a questionna...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03556-4

    authors: Abu Freha N,Abu Tailakh M,Elkrinawi J,Abu Kaf H,Philip A,Schwartz D,Yahia A,Etzion O

    更新日期:2020-07-01 00:00:00

  • Utility of a three-dimensional printed pelvic model for lateral pelvic lymph node dissection.

    abstract:PURPOSE:In patients with advanced lower rectal cancer, the complex pelvic anatomy renders lateral pelvic lymph node dissection to be challenging. Therefore, we evaluated the utility of printing a three-dimensional (3D) pelvic model for lateral pelvic lymph node dissection. METHODS:We included 22 patients who underwent...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03534-w

    authors: Hojo D,Murono K,Nozawa H,Kawai K,Hata K,Tanaka T,Ishihara S

    更新日期:2020-05-01 00:00:00