Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports.

Abstract:

PURPOSE:Kras mutations are negative predictors of anti-EGFR therapy, occurring in 40% of colorectal carcinomas (CRCs). Point substitutions in codon 12 or 13 are the most frequent mutations in Kras, but multiple mutations (MMs) in other codons can also develop. Few data exist on MMs with regard to their frequency and the codons and amino acids that are affected. We report two cases of Kras double mutations in codons 12 and 13 and review Kras MMs in primary CRC in PubMed databases. CASE REPORT:A 53-year-old woman and a 70-year-old man presented with deep, invasive, moderately differentiated CRC at an advanced clinical stage. The former had regional lymph node involvement and vaginal wall neoplastic implantation, and the latter had liver metastasis. Primary tumors were examined for Kras mutations by pyrosequencing, which were confirmed by direct sequencing. Both tumors had a mutation in codons 12 and 13, wherein codon 12 was mutated to GAT, and codon 13 became GAC. CONCLUSIONS:We identified 69 reported cases of Kras MMs and reported two other cases, representing 2.1% of all mutated tumors; the incidence of such mutations is 1.0% in CRC patients. In most cases (59%), MMs develop in a single codon, usually codon 12. Codons 12 and 13 are affected simultaneously in only 27% of cases. These findings add information about the impact of specific amino acid changes in the Kras gene.

journal_name

Int J Colorectal Dis

authors

Macedo MP,Andrade Lde B,Coudry R,Crespo R,Gomes M,Lisboa BC,Aguiar S Jr,Soares FA,Carraro DM,Cunha IW

doi

10.1007/s00384-011-1238-0

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1241-8

issue

10

eissn

0179-1958

issn

1432-1262

journal_volume

26

pub_type

杂志文章,评审
  • The prognosis of clinical course and the analysis of the frequency of the inflammation and dysplasia in the intestinal J-pouch at the patients after restorative proctocolectomy due to FAP.

    abstract:PURPOSE:The main operative method in familial adenomatous polyposis (FAP) patients is restorative proctocolectomy with "J"-shaped pouch and temporary loop ileostomy. The aim of the study was the analysis of the frequency of the dysplasia and inflammation in the intestinal pouch and prognosis of the clinical course in F...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-011-1241-5

    authors: Banasiewicz T,Marciniak R,Kaczmarek E,Krokowicz P,Paszkowski J,Lozynska-Nelke A,Gronek P,Plawski A,Drews M

    更新日期:2011-09-01 00:00:00

  • Impact of implementation of the ERAS program in colorectal surgery: a multi-center study based on the "Lazio Network" collective database.

    abstract:BACKGROUND:ERAS implementation improved outcomes in patients undergoing colorectal surgery. The process of incorporating this pathway in clinical practice may be challenging. This observational study investigated the impact of systematic ERAS implementation on surgical outcomes in patients undergoing colorectal resecti...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00384-019-03496-8

    authors: Grieco M,Lorenzon L,Pernazza G,Carlini M,Brescia A,Santoro R,Crucitti A,Palmieri RM,Santoro E,Stipa F,Sacchi M,Persiani R

    更新日期:2020-03-01 00:00:00

  • Mega-megacolon: a case report.

    abstract:PURPOSE:Large bowel obstruction and megacolon formation secondary to complicated diverticulitis is rare. METHODS:We present a case of an 84-year-old woman surviving large bowel obstruction and mega-megacolon formation secondary to complicated diverticulitis, with an impressive presentation of abdominal distention. RE...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03642-7

    authors: Larentzakis A,Kalyva A,Kantas T,Michalopoulos NV,Zografos CG,Zografos GC

    更新日期:2020-08-01 00:00:00

  • Chronic posterior tibial nerve transcutaneous electrical nerve stimulation (TENS) to treat fecal incontinence (FI).

    abstract:AIM:Transcutaneous electrical nerve stimulation (TENS) is a possible alternative to sacral nerve stimulation because the neurophysiologic targets might be similar but the former method is non-invasive and cheaper. The aim of the study was to assess both symptom and quality of life (QoL) improvements in patients sufferi...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00384-010-0960-3

    authors: Eléouet M,Siproudhis L,Guillou N,Le Couedic J,Bouguen G,Bretagne JF

    更新日期:2010-09-01 00:00:00

  • Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells.

    abstract::The mechanisms of the antineoplastic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) still are unknown, but the induction of apoptosis is one of the possible mechanisms. We attempted to demonstrate the role of mitogen-activated protein (MAP) kinases, generally considered to be important mediators of proliferat...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840100301

    authors: Kim TI,Jin SH,Kim WH,Kang EH,Choi KY,Kim HJ,Shin SK,Kang JK

    更新日期:2001-06-01 00:00:00

  • Primary resection and synchronous regional hepatic chemotherapy or cryotherapy for colorectal cancer with liver metastases.

    abstract::Twenty-two patients with colorectal cancer and synchronous unresectable hepatic metastases were treated by resection the primary tumour with concurrent insertion of an Infusaid infusaport system for regional chemoperfusion (hepatic arterial 20, portal venous 2). Four patients in addition had cryotherapy the liver meta...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF00418854

    authors: Dasappa V,Ross WB,King J,King DW,Clingan PR,Morris DL

    更新日期:1996-01-01 00:00:00

  • (E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa.

    abstract:BACKGROUND:Nicotine is of therapeutic value in ulcerative colitis, but its administration is connected with adverse events. Nicotine derivatives are currently being tested to maintain the therapeutic effects and minimize adverse events. TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to dete...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-006-0135-4

    authors: Spoettl T,Paetzel C,Herfarth H,Bencherif M,Schoelmerich J,Greinwald R,Gatto GJ,Rogler G

    更新日期:2007-03-01 00:00:00

  • Detection of circulating tumor cells in patients with locally advanced rectal cancer undergoing neoadjuvant therapy followed by curative surgery.

    abstract:PURPOSE:Circulating tumor cells (CTCs) represent an independent prognostic factor in metastatic colorectal cancer, while their significance in early stages is still an open issue. The aim of the study is to investigate the role of CTCs in rectal cancer patients undergoing neoadjuvant chemoradiotherapy (CT-RT). METHODS...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-014-1958-z

    authors: Magni E,Botteri E,Ravenda PS,Cassatella MC,Bertani E,Chiappa A,Luca F,Zorzino L,Bianchi PP,Adamoli L,Sandri MT,Zampino MG

    更新日期:2014-09-01 00:00:00

  • Peritoneal fluid biomarkers in the detection of colorectal anastomotic leaks: a systematic review.

    abstract:PURPOSE:Anastomotic leak (AL) in colorectal surgery leads to significant morbidity, mortality and poorer oncological outcomes. Diagnosis of AL is frequently delayed as current methods of detection are not 100% sensitive or specific. 'Biomarkers', such as cytokines and markers of ischaemia, from the milieu of the anasto...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00384-017-2799-3

    authors: Wright EC,Connolly P,Vella M,Moug S

    更新日期:2017-07-01 00:00:00

  • Risk of lymph node metastasis after endoscopic treatment for rectal NETs 10 mm or less.

    abstract:PURPOSE:For rectal neuroendocrine tumors (NETs) ≤ 10 mm, endoscopic resection is a standard treatment. However, there is no consensus whether additional surgery should be performed for patients at risk of lymph node metastasis (LNM) after endoscopic resection. The purpose of this study was to analyze the results of end...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03826-1

    authors: Inada Y,Yoshida N,Fukumoto K,Hirose R,Inoue K,Dohi O,Murakami T,Ogiso K,Tomie A,Kugai M,Yoriki H,Inagaki Y,Hasegawa D,Okuda K,Okuda T,Morinaga Y,Kishimoto M,Itoh Y

    更新日期:2021-01-02 00:00:00

  • Abnormal expression of E-cadherin, beta-catenin, and c-erbB-2 in advanced gastric cancer: its association with liver metastasis.

    abstract:BACKGROUND AND AIMS:We investigated expression of E-cadherin, beta-catenin, and c-erbB-2 in gastric cancer to identify molecular factor(s) relevant to development of liver metastasis, which is a frequent cause of mortality in gastric cancer patients. PATIENTS AND METHODS:We analyzed by immunohistochemistry and compare...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-002-0427-2

    authors: Ougolkov A,Yamashita K,Bilim V,Takahashi Y,Mai M,Minamoto T

    更新日期:2003-03-01 00:00:00

  • Usefulness of anorectal and endovaginal 3D ultrasound in the evaluation of sphincter and pubovisceral muscle defects using a new scoring system in women with fecal incontinence after vaginal delivery.

    abstract:PURPOSE:This study aims to evaluate pubovisceral muscle and anal sphincter defects in women with previous vaginal delivery and fecal incontinence and to correlate the findings with the severity of symptoms using the combined anorectal and endovaginal 3D ultrasonography with a new ultrasound scoring system. METHODS:Con...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2750-z

    authors: Murad-Regadas SM,da S Fernandes GO,Regadas FS,Rodrigues LV,Filho FS,Dealcanfreitas ID,da Silva Vilarinho A,da Cruz MM

    更新日期:2017-04-01 00:00:00

  • Predictive value of VEGF gene polymorphisms for metastatic colorectal cancer patients receiving first-line treatment including fluorouracil, irinotecan, and bevacizumab.

    abstract:PURPOSE:The aim of this study is to evaluate the influence of germline vascular endothelial growth factor (VEGF) gene polymorphisms (VGPs) on the efficacy of the anti-VEGF antibody bevacizumab (Bev) in metastatic colorectal cancer (MCRC) patients. METHODS:Forty MCRC patients eligible for a first-line therapy were enro...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-010-1108-1

    authors: Formica V,Palmirotta R,Del Monte G,Savonarola A,Ludovici G,De Marchis ML,Grenga I,Schirru M,Guadagni F,Roselli M

    更新日期:2011-02-01 00:00:00

  • BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability.

    abstract:BACKGROUND AND AIMS:Hereditary nonpolyposis colorectal cancer (HNPCC) and a subset of sporadic colorectal cancers are characterized by microsatellite instability (MSI) and inactivating frameshift mutations of target genes. Inactivation of BAX, caspase-5 ( cas-5), and other genes coding for pro-apoptotic proteins might ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-004-0597-1

    authors: Trojan J,Brieger A,Raedle J,Weber N,Kriener S,Kronenberger B,Caspary WF,Zeuzem S

    更新日期:2004-11-01 00:00:00

  • Rectal endosonography for the visualisation of the anastomosis after anterior resection and its relevance to local recurrence.

    abstract::Rectal endosonography can be used to detect and localise recurrent rectal carcinoma. Distal and proximal to a rectal anastomosis the separate layers of the bowel wall as seen by rectal endosonography are well defined but at the precise level of the anastomosis separation of the layers is lost and they appear to merge....

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF00300400

    authors: Charnley RM,Heywood MF,Hardcastle JD

    更新日期:1990-08-01 00:00:00

  • The role of single-shot metronidazole in the prevention of Clostridium difficile infection following ileostomy reversal surgery.

    abstract:PURPOSE:Symptomatic infection with Clostridium difficile is strongly linked to antibiotic use and rates are higher for colorectal surgery. In February 2015, trust policy for antibiotic prophylaxis of ileostomy reversal surgery was changed from three doses of metronidazole plus cefuroxime to single-dose metronidazole, i...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2725-0

    authors: Fernandes R,Robinson P,Rangarajan K,Scott S,Angco L

    更新日期:2017-05-01 00:00:00

  • Correction to: how can primary care practitioners address substance use by adolescents? A position paper of the EUROPEAN academy of PEDIATRICS.

    abstract::The authors of the published version of this article inadvertently omitted the table note of the Table 2 under the Appendix section. The complete Table 2 is shown in this article]. ...

    journal_title:International journal of colorectal disease

    pub_type: 已发布勘误

    doi:10.1007/s00384-020-03572-4

    authors: Michaud PA,Bélanger R,Mazur A,Hadjipanayis A,Ambresin AE

    更新日期:2020-04-20 00:00:00

  • Measurement of the anorectal angle by defecography for the diagnosis of fecal incontinence.

    abstract::We assessed the reliability of anorectal angle (ARA) measurement as an index of fecal incontinence. The "posterior" ARA was measured at rest, squeezing, and straining in 69 continent and 82 incontinent subjects all complaining of various evacuation dysfunctions. The two groups were homogeneous with regard to sex distr...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840050198

    authors: Piloni V,Fioravanti P,Spazzafumo L,Rossi B

    更新日期:1999-04-01 00:00:00

  • Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.

    abstract:INTRODUCTION:Intestinal adenosquamous carcinoma (ASC) is a rare colorectal neoplasm frequently occurring at onset as a locally advanced disease with distant metastases. The liver is the most common site of metastasis, followed by the peritoneum and the lung. Cutaneous metastases from usual colorectal adenocarcinoma occ...

    journal_title:International journal of colorectal disease

    pub_type:

    doi:10.1007/s00384-019-03464-2

    authors: Parente P,Covelli C,Parrella P,Latiano TP,Fiordelisi F,Pellico MT,Maiello E,Graziano P

    更新日期:2020-02-01 00:00:00

  • Nomogram for predicting anastomotic leakage after low anterior resection for rectal cancer.

    abstract:PURPOSE:Anastomotic leakage after low anterior resection for rectal cancer is a critical problem. Many risk factors have been suggested and surgical techniques have improved, but anastomotic leakage remains a major postoperative challenge. This study sought to create a nomogram for precise prediction of anastomotic lea...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-2970-5

    authors: Hoshino N,Hida K,Sakai Y,Osada S,Idani H,Sato T,Takii Y,Bando H,Shiomi A,Saito N

    更新日期:2018-04-01 00:00:00

  • Preoperative adipocytokines as a predictor of surgical infection after colorectal surgery: a prospective survey.

    abstract:BACKGROUND:Infections are the leading cause of morbidity and mortality after colorectal surgery. Obesity is a well-known risk factor for wound infection, but it does not seem to increase the risk of other infectious complications. The aim of this study was to look for a relationship between the fatty tissue metabolism ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-013-1782-x

    authors: Ortega-Deballon P,Duvillard L,Scherrer ML,Deguelte-Lardière S,Bourredjem A,Petit JM,Bonithon-Kopp C,AGARIC Study group.

    更新日期:2014-01-01 00:00:00

  • Ileostomy adenocarcinoma in Crohn's disease.

    abstract:PURPOSE:Adenocarcinoma of an ileostomy is rare with less than 50 reported cases in the literature. Ileostomy adenocarcinoma in Crohn's disease is even more rare, with only 4 reported cases. We present a case of ileostomy adenocarcinoma with lymph node metastasis occurring 51 years after proctocolectomy and Brooke ileos...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03554-6

    authors: Yousaf A,Beatty C,Zinn Z,Cassim R,Gayam S

    更新日期:2020-05-01 00:00:00

  • CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue.

    abstract:BACKGROUND AND AIMS:Pouchitis is the major long-term complication after ileal pouch-anal anastomosis (IPAA) in patients operated on for ulcerative colitis. The cause is unknown, but both the history of ulcerative colitis and increased bacterial concentration are important factors. Chemokines are mediators for the recru...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-003-0500-5

    authors: Helwig U,Gionchetti P,Rizzello F,Lammers K,Kühbacher T,Schreiber S,Baggiolini M,Uguccioni M,Campieri M

    更新日期:2004-03-01 00:00:00

  • Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis.

    abstract:BACKGROUND/AIM:In order to define future chemoprevention strategies for adenomas or carcinomas in the pouch of patients with familial adenomatous polyposis (FAP), a 4-weeks intervention with (1) sulindac, (2) inulin/VSL#3, and (3) sulindac/inulin/VSL#3 was performed on 17 patients with FAP in a single center interventi...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00384-010-1127-y

    authors: Friederich P,Verschuur J,van Heumen BW,Roelofs HM,Berkhout M,Nagtegaal ID,van Oijen MG,van Krieken JH,Peters WH,Nagengast FM

    更新日期:2011-05-01 00:00:00

  • Sacral neuromodulation in children and adolescents with chronic constipation refractory to conservative treatment.

    abstract:PURPOSE:Functional constipation in children and adolescents is a common and invalidating condition. In a minority of patients, symptoms persist despite optimal conservative therapy. The aim of this study was to evaluate whether the short-term effects of sacral neuromodulation (SNM) in children and adolescents with cons...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2604-8

    authors: van der Wilt AA,van Wunnik BP,Sturkenboom R,Han-Geurts IJ,Melenhorst J,Benninga MA,Baeten CG,Breukink SO

    更新日期:2016-08-01 00:00:00

  • hTERT expression in colorectal adenocarcinoma: correlations with p21, p53 expressions and clinicopathological features.

    abstract:BACKGROUND:The clinicopathological roles and relationships of hTERT, p21 and p53 proteins have not been studied in depth in colorectal cancer. The aim of the present study is to investigate the clinicopathological roles of expression of hTERT protein expression and its relationship with the expression of p21 and p53 pr...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-008-0455-7

    authors: Lam AK,Ong K,Ho YH

    更新日期:2008-06-01 00:00:00

  • Bilateral type diverticular disease of the colon.

    abstract::7,543 double-contrast barium enema studied for the presence of diverticula which were classified into right-sided, left-sided and bilateral types, and the relationship of the frequency (detection rate) and numbers of diverticula to age were examined for the earlier (1982-87) and later (1988-92) periods. Diverticular d...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF00342463

    authors: Miura S,Kodaira S,Aoki H,Hosoda Y

    更新日期:1996-01-01 00:00:00

  • Survival after acute colon diverticulitis treated in hospital.

    abstract:PURPOSE:The aim of this study was to determine the short- and long-term relative survival as well as the causes of death in patients treated in hospital for acute colonic diverticulitis. MATERIALS AND METHODS:The study included all patients treated at Levanger Hospital for acute colonic diverticulitis between 1988 and...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-014-1946-3

    authors: Edna TH,Jamal Talabani A,Lydersen S,Endreseth BH

    更新日期:2014-11-01 00:00:00

  • Traumatic lesions of the rectum.

    abstract::Twenty-two patients treated for rectal trauma between 1975 and 1985 were reviewed. There were 13 males and nine females, of mean age 38 years (18-72 years). Causes included gunshot (2), sexual trauma (8), road accident (5), impalement (5), polypectomy (2). Two patients died, giving a treatment mortality of 9%. Cases w...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF01648441

    authors: Marti MC,Morel P,Rohner A

    更新日期:1986-07-01 00:00:00

  • Emergency subtotal/total colectomy in the management of obstructed left colon carcinoma.

    abstract:PURPOSE:The treatment of acutely obstructed carcinoma of the left colon still represents a matter of controversy. The aim of the study was to evaluate the results of its management by emergency subtotal or total colectomy with immediate anastomosis without diversion. METHODS:An emergency subtotal/total colectomy was p...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-005-0048-7

    authors: Hennekinne-Mucci S,Tuech JJ,Bréhant O,Lermite E,Bergamaschi R,Pessaux P,Arnaud JP

    更新日期:2006-09-01 00:00:00