当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF COLORECTAL DISEASE期刊下所有文献 > Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports.

Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports.

Abstract：

PURPOSE:Kras mutations are negative predictors of anti-EGFR therapy, occurring in 40% of colorectal carcinomas (CRCs). Point substitutions in codon 12 or 13 are the most frequent mutations in Kras, but multiple mutations (MMs) in other codons can also develop. Few data exist on MMs with regard to their frequency and the codons and amino acids that are affected. We report two cases of Kras double mutations in codons 12 and 13 and review Kras MMs in primary CRC in PubMed databases. CASE REPORT:A 53-year-old woman and a 70-year-old man presented with deep, invasive, moderately differentiated CRC at an advanced clinical stage. The former had regional lymph node involvement and vaginal wall neoplastic implantation, and the latter had liver metastasis. Primary tumors were examined for Kras mutations by pyrosequencing, which were confirmed by direct sequencing. Both tumors had a mutation in codons 12 and 13, wherein codon 12 was mutated to GAT, and codon 13 became GAC. CONCLUSIONS:We identified 69 reported cases of Kras MMs and reported two other cases, representing 2.1% of all mutated tumors; the incidence of such mutations is 1.0% in CRC patients. In most cases (59%), MMs develop in a single codon, usually codon 12. Codons 12 and 13 are affected simultaneously in only 27% of cases. These findings add information about the impact of specific amino acid changes in the Kras gene.

journal_name

Int J Colorectal Dis

journal_title

International journal of colorectal disease

authors

Macedo MP,Andrade Lde B,Coudry R,Crespo R,Gomes M,Lisboa BC,Aguiar S Jr,Soares FA,Carraro DM,Cunha IW

doi

10.1007/s00384-011-1238-0

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1241-8

issue

10

eissn

0179-1958

issn

1432-1262

journal_volume

26

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE文献大全
  • BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability.

    abstract：BACKGROUND AND AIMS:Hereditary nonpolyposis colorectal cancer (HNPCC) and a subset of sporadic colorectal cancers are characterized by microsatellite instability (MSI) and inactivating frameshift mutations of target genes. Inactivation of BAX, caspase-5 ( cas-5), and other genes coding for pro-apoptotic proteins might ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-004-0597-1

    authors： Trojan J,Brieger A,Raedle J,Weber N,Kriener S,Kronenberger B,Caspary WF,Zeuzem S

    更新日期：2004-11-01 00:00:00

  • Palliative cryosurgery for rectal carcinoma.

    abstract：:Cryosurgery is one of the palliative treatment options to decrease local symptoms due to rectal carcinoma. A total of 106 patients (aged 45-92 years) underwent palliative cryosurgery for primary rectal cancer. Inclusion criteria were prohibitive surgical risk, unresectability, distant metastases, patient refusal of su...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章

    doi：10.1007/s003840050206

    authors： Meijer S,Rahusen FD,van der Plas LG

    更新日期：1999-08-01 00:00:00

  • Endoscopic stenting and elective surgery versus emergency surgery for left-sided malignant colonic obstruction: a prospective randomized trial.

    abstract：PURPOSE:This study aims to evaluate the role of colonic stenting as a bridge to surgery in acutely obstructed left-sided colon cancer. METHODS:Patients with acute left-sided malignant colonic obstruction with no evidence of peritonitis were recruited. After informed consent, patients were randomized to colonic stentin...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00384-011-1331-4

    authors： Ho KS,Quah HM,Lim JF,Tang CL,Eu KW

    更新日期：2012-03-01 00:00:00

  • Transanal local resection for benign and malignant rectal tumours.

    abstract：:Local therapy has been widely reported and accepted for benign tumours and carefully selected cancers of the rectum. Thirty-three patients with benign or malignant low rectal tumors have undergone a prospective evaluation after local resection with transanal electroresection as described by Faivre. Patients were divid...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00341209

    authors： Piccinini EE,Ugolini G,Rosati G,Conti A

    更新日期：1995-01-01 00:00:00

  • Rescue therapy with tacrolimus in a patient with toxic megacolon.

    abstract：BACKGROUND:Toxic megacolon is a life-threatening complication most commonly observed in patients with ulcerative colitis or Crohn's disease that is characterized by total or segmental nonobstructive colonic dilatation of at least 6 cm on plain abdominal films associated with systemic toxicity. CASE REPORT:We report an...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-002-0458-8

    authors： Pascu M,Müller AR,Wiedenmann B,Dignass AU

    更新日期：2003-05-01 00:00:00

  • Is emergency right hemicolectomy still associated with significant morbidity and mortality rates? An institution's experience of 207 cases over 6 years.

    abstract：INTRODUCTION:Emergency right hemicolectomy has been associated with dismal outcome. But, data in Asians is lacking as pathologies that require emergency right hemicolectomy may differ from that in the Western population. The aims of our study were to review our institution's experience with emergency right hemicolectom...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-011-1203-y

    authors： Tan KK,Liu JZ,Yeow Y,Gunasekaran S,Tan JJ

    更新日期：2011-09-01 00:00:00

  • Functional outcome and quality of life following restorative proctocolectomy for ulcerative colitis in Indians.

    abstract：BACKGROUND:The functional outcome and quality of life after sphincter-saving operations for ulcerative colitis have not been previously assessed in Indian patients whose dietary habits and socio-cultural practices differ considerably from those in western countries. PATIENTS AND METHODS:Between 1996 and 2002, we perfo...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-010-0974-x

    authors： Somashekar U,Gupta S,Soin A,Nundy S

    更新日期：2010-08-01 00:00:00

  • Risk factors for ileus after hip and knee arthroplasty.

    abstract：PURPOSE:Postoperative ileus (POI) is one of the complications that can occur after every surgical procedure including arthroplasty. It can have detrimental consequences for the patient and portrays an economic burden on health care systems. The risk factors for POI after arthroplasty described in the literature are sca...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-018-3184-6

    authors： Klasan A,Amic F,Dworschak P,Madzarac G,Heyse TJ,Neri T

    更新日期：2019-02-01 00:00:00

  • Bilobar spreading of colorectal liver metastases does not significantly affect survival after R0 resection in the era of interdisciplinary multimodal treatment.

    abstract：PURPOSE:Bilobar colorectal liver metastases (CRLM) are often considered incurable or associated with poor prognosis even after R0 resection. In this single-center study, we evaluate the impact of CRLM spreading on recurrence-free survival (RFS) and cancer-specific overall survival (CSS) after R0 resection of CRLM with ...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00384-012-1455-1

    authors： Homayounfar K,Bleckmann A,Conradi LC,Sprenger T,Beissbarth T,Lorf T,Niessner M,Sahlmann CO,Meller J,Becker H,Liersch T,Ghadimi BM

    更新日期：2012-10-01 00:00:00

  • Laparoscopic and open resection of rectal cancer-is age an effect modifier for short- and long-term survival?

    abstract：INTRODUCTION:Rectal cancer is a frequently diagnosed tumor worldwide. Various studies have shown the noninferiority or even slight superiority of laparoscopic resection. However, there is no clear recommendation on whether age should influence the choice of surgical approach. MATERIALS AND METHODS:This study compared ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-019-03265-7

    authors： Draeger T,Völkel V,Schnitzbauer V,Gerken M,Benz S,Klinkhammer-Schalke M,Fürst A

    更新日期：2019-05-01 00:00:00

  • Strictureplasty for active Crohn's disease.

    abstract：BACKGROUND AND AIMS:Several studies over the last 20 years have confirmed the safety and efficacy of strictureplasty in the treatment of obstructive Crohn's disease. However, almost all of these studies use strictureplasty to treat fibrotic strictures: limited resection being preferred to treat active disease stricture...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-005-0029-x

    authors： Roy P,Kumar D

    更新日期：2006-07-01 00:00:00

  • Spatiotemporal expression of Wnt5a during the development of the hindgut and anorectum in human embryos.

    abstract：PURPOSE:The aim of the study was to determine the spatiotemporal expression of Wnt5a during hindgut and anorectum development in human embryos and to explore the possible role of Wnt5a during the morphogenesis of the human hindgut and anorectum. MATERIALS AND METHODS:The embryos (n = 107) were sectioned serially and s...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-011-1191-y

    authors： Li FF,Zhang T,Bai YZ,Yuan ZW,Wang WL

    更新日期：2011-08-01 00:00:00

  • The effects of fast-track surgery on inflammation and immunity in patients undergoing colorectal surgery.

    abstract：OBJECTIVE:The objective of this study is to explore the effects of the fast-track surgery (FTS) program on inflammation and immunity in patients undergoing colorectal surgery. METHODS:From August 2014 to March 2015, a prospective and randomized controlled trial of 230 patients who underwent colorectal surgery was perf...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00384-016-2630-6

    authors： Feng J,Li K,Li L,Wang X,Huang M,Yang J,Hu Y

    更新日期：2016-10-01 00:00:00

  • Association between increased tumor necrosis factor alpha levels and acquired activated protein C resistance in patients with metastatic colorectal cancer.

    abstract：PURPOSE:The purpose of this study was to investigate the possible association between tumor necrosis factor-α (TNF-α) levels and defects in the activated protein C (APC) system as a determinant of venous thromboembolism (VTE) in metastatic colorectal cancer patients (mCRC) undergoing chemotherapy. METHODS:TNF-α levels...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-012-1493-8

    authors： Ferroni P,Riondino S,Portarena I,Formica V,La Farina F,Martini F,Massimiani G,Palmirotta R,Guadagni F,Roselli M

    更新日期：2012-12-01 00:00:00

  • Low expression of chemokine receptor CCR5 in human colorectal cancer correlates with lymphatic dissemination and reduced CD8+ T-cell infiltration.

    abstract：BACKGROUND:Chemokines and their receptors have been proposed to distinctly contribute to tumor growth, dissemination, and local immune escape. The aim of this study was to evaluate the relevance of the chemokine receptor CCR5 expression for the progression of human colorectal cancer. METHODS:CCR5 expression was assess...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-009-0868-y

    authors： Zimmermann T,Moehler M,Gockel I,Sgourakis GG,Biesterfeld S,Müller M,Berger MR,Lang H,Galle PR,Schimanski CC

    更新日期：2010-04-01 00:00:00

  • Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study.

    abstract：:In hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, more than 90% of the carcinomas show microsatellite instability (MSI) due to a loss of mismatch repair (MMR) function. Although adenomas are very common in HNPCC and demonstrate an accelerated adenoma-carcinoma sequence, data about the prevalence and devel...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-005-0073-6

    authors： German HNPCC Consortium.,Müller A,Beckmann C,Westphal G,Bocker Edmonston T,Friedrichs N,Dietmaier W,Brasch FE,Kloor M,Poremba C,Keller G,Aust DE,Fass J,Büttner R,Becker H,Rüschoff J

    更新日期：2006-10-01 00:00:00

  • Characteristic findings on defecography according to reconstruction method and defecatory disorder following sphincter-saving surgery for rectal cancer.

    abstract：BACKGROUND AND AIMS:This study used postoperative defecography to characterize morphological features of defecatory disorders in patients following rectal resection. We also evaluated differences in dynamic defecatory condition depending on reconstruction methods for sphincter-saving surgery. MATERIALS AND METHODS:Sub...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-008-0485-1

    authors： Morihiro M,Koda K,Seike K,Miyauchi H,Miyazaki M

    更新日期：2008-09-01 00:00:00

  • A simple bowel habit score for colorectal patients.

    abstract：PURPOSE:The assessment of bowel habit is important in the management of patients with colorectal disease. There is not an ideal and practical bowel habit scoring system. The current scores have been designed only for a subclass of patients having a particular disorder. Furthemore, they are complex and time consuming. W...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-016-2677-4

    authors： Zinicola R,Cracco N,Totaro A,Dalla Valle R,Pedrazzi G

    更新日期：2017-01-01 00:00:00

  • Pelvic pouch emptying scan: an evaluation of scintigraphic assessment of the neorectum.

    abstract：:Although scintigraphic pelvic pouch emptying scans have been used to evaluate neorectal function in patients who have undergone colectomy, mucosal proctectomy, and ileoanal pouch anastomosis, previous reports have not documented the reliability of this test in measuring pouch volume and emptying. Thus, this study was ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/BF00703957

    authors： Woolfson K,McLeod RS,Walfisch S,Yip K,Cohen Z

    更新日期：1991-02-01 00:00:00

  • Gross and histological abnormalities of the foregut in familial adenomatous polyposis: a study from a South East Asian Registry.

    abstract：:Polyps in the stomach and duodenum are frequently found in familial adenomatous polyposis. Cancer arising from some of these polyps may be an important cause of death in patients who have had large bowel resections. This study aims to determine the nature and distribution of foregut polyps in Chinese patients. Twenty-...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/BF00341216

    authors： Seow-Choen F,Ho JM,Wong J,Goh HS

    更新日期：1992-12-01 00:00:00

  • CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue.

    abstract：BACKGROUND AND AIMS:Pouchitis is the major long-term complication after ileal pouch-anal anastomosis (IPAA) in patients operated on for ulcerative colitis. The cause is unknown, but both the history of ulcerative colitis and increased bacterial concentration are important factors. Chemokines are mediators for the recru...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-003-0500-5

    authors： Helwig U,Gionchetti P,Rizzello F,Lammers K,Kühbacher T,Schreiber S,Baggiolini M,Uguccioni M,Campieri M

    更新日期：2004-03-01 00:00:00

  • Time-saving polyp detection in colon capsule endoscopy: evaluation of a novel software algorithm.

    abstract：BACKGROUND:Colon capsule endoscopy (CCE) is a reliable method to detect colonic polyps in the well-prepared colon. As CCE evaluation can be time consuming, a new software algorithm might aid in reducing evaluation time. OBJECTIVES:The aim of the study was to evaluate whether it is feasible to reliably detect colon pol...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-019-03393-0

    authors： Hausmann J,Linke JP,Albert JG,Masseli J,Tal A,Kubesch A,Filmann N,Philipper M,Farnbacher M

    更新日期：2019-11-01 00:00:00

  • Is ascites CEA a risk factor for peritoneal carcinomatosis in colorectal cancer?: a long-term follow-up study.

    abstract：PURPOSE:Our previous study reported that carcinoembryonic antigen (CEA) levels in peritoneal fluid were significantly correlated with the prevalence of peritoneal carcinomatosis (PC) in colorectal cancer (CRC). The purpose of this study was a long-term follow up of the author's previous study, as well as the identifica...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-019-03448-2

    authors： Kim BC,Bae JH,Park SM,Won DY,Lee IK

    更新日期：2020-01-01 00:00:00

  • Safety, feasibility, and tolerance of early oral feeding after colorectal resection outside an enhanced recovery after surgery (ERAS) program.

    abstract：INTRODUCTION:It is generally believed that resumption of feeding after colorectal resection is indicated only after recovery of bowel function. This study was designed to verify safety, feasibility, and tolerance of early oral postoperative feeding (EOF) outside an enhanced recovery after surgery (ERAS) program. MATER...

    journal_title：International journal of colorectal disease

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00384-011-1138-3

    authors： Gianotti L,Nespoli L,Torselli L,Panelli M,Nespoli A

    更新日期：2011-06-01 00:00:00

  • SLIT2 inhibits cell migration in colorectal cancer through the AKT-GSK3β signaling pathway.

    abstract：PURPOSE:Colorectal cancer is a common malignancy and one of the major causes of cancer-related deaths worldwide. Similar to other human cancers, tumor metastasis is the biggest obstacle in the clinical treatment of colorectal cancer. In this study, we explored the functional role of SLIT2 in colon tumor metastasis and ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-013-1641-9

    authors： Chen WF,Gao WD,Li QL,Zhou PH,Xu MD,Yao LQ

    更新日期：2013-07-01 00:00:00

  • Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells.

    abstract：BACKGROUND AND AIMS:Photodynamic therapy (PDT) is a new treatment modality for early esophageal neoplasia. With two absorption maxima in the visible light range (550 and 588 nm) hypericin is a very promising photosensitizer for PDT with incoherent light sources. We studied the effects of photosensitizing hypericin in b...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-002-0440-5

    authors： Höpfner M,Maaser K,Theiss A,Lenz M,Sutter AP,Kashtan H,von Lampe B,Riecken EO,Zeitz M,Scherübl H

    更新日期：2003-05-01 00:00:00

  • Indocyanine green fluorescent imaging on anastomotic leakage in colectomies: a network meta-analysis and systematic review.

    abstract：PURPOSE:The usage of indocyanine green (ICG) dye is commonly associated with decreased anastomotic leakage rates in colectomies. This study aims to perform a network meta-analysis to assess the usage of ICG fluorescence imaging in right-sided colectomies. METHODS:Medline, Embase, Cochrane Trials, CNKI, and WanFang ele...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-020-03723-7

    authors： Mok HT,Ong ZH,Yaow CYL,Ng CH,Buan BJL,Wong NW,Chong CS

    更新日期：2020-12-01 00:00:00

  • Accuracy of colonoscopy in localisation of colorectal cancer.

    abstract：:An audit was performed of 77 patients with a single colorectal cancer visualised and sited before surgery by colonoscopic examination. The site of the cancer described at colonoscopy was compared with the actual site found at laparotomy. Six significant errors in preoperative localisation were encountered, when a chan...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/BF00298535

    authors： Hancock JH,Talbot RW

    更新日期：1995-01-01 00:00:00

  • Robotic rectal cancer surgery in obese patients may lead to better short-term outcomes when compared to laparoscopy: a comparative propensity scored match study.

    abstract：PURPOSE:Laparoscopic rectal surgery in obese patients is technically challenging. The technological advantages of robotic instruments can help overcome some of those challenges, but whether this translates to superior short-term outcomes is largely unknown. The aim of this study is to compare the short-term surgical ou...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-018-3030-x

    authors： Panteleimonitis S,Pickering O,Abbas H,Harper M,Kandala N,Figueiredo N,Qureshi T,Parvaiz A

    更新日期：2018-08-01 00:00:00

  • The prevention of colorectal anastomotic leakage with tissue adhesives in a contaminated environment is associated with the presence of anti-inflammatory macrophages.

    abstract：BACKGROUND:Colorectal anastomoses created in a contaminated environment result in a high leakage rate. This study investigated whether using anastomotic sealants (TissuCol(®), Histoacryl(®) Flex, and Duraseal(®)) prevents leakage in a rat peritonitis model. STUDY DESIGN:Sixty-seven Wistar rats were divided into contro...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-014-2012-x

    authors： Wu Z,Vakalopoulos KA,Boersema GS,Kroese LF,Lam KH,van der Horst PH,Mulder IM,Bastiaansen-Jenniskens YM,Kleinrensink GJ,Jeekel J,Lange JF

    更新日期：2014-12-01 00:00:00