当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF COLORECTAL DISEASE期刊下所有文献 > The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth.

The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth.

Abstract：

INTRODUCTION:The transplantation of neural crest derived stem cells (NCSC) is a potent alternative for the treatment of Hirschsprung's disease (HSCR). Cells to be transplanted should find an appropriate microenvironment to survive and differentiate. Influences of HSCR-smooth-muscle-protein extracts upon isolated myenteric plexus cells, dissociated dorsal root ganglia and NCSC were studied in vitro to investigate the quality of this microenvironment effects. METHODS:Postnatal human gut from children undergoing colonic resection due to HSCR was divided in segments. Smooth muscle was dissected and homogenized. Glial-cell-line-derived-neurotrophic-factor (GDNF) and transforming-growth-factor-β-1 (TGFβ-1) concentration were measured in the homogenates from the individual segment using ELISA. Myenteric plexus and dissociated dorsal root ganglia (DRG) cultures, as well as NCSCs were exposed to protein extracts derived from ganglionic and aganglionic HSCR segments, and their effect upon neurite outgrowth, survival, and branching was evaluated. RESULTS AND CONCLUSIONS:The amount of the factors varied considerably between the individual segments and also from patient to patient. Four major expression patterns could be detected. While all extracts tested lead to a significant increase in neurite outgrowth compared to the control, extracts from proximal segments tended to have more prominent effects. In one experiment, extracts from all individual segments of a single patient were tested. Neurite outgrowth, neuronal survival, and branching pattern varied from segment to segment, but all HSCR-muscle-protein extracts increased neuronal survival and network formation. Smooth muscle protein from aganglionic bowel supports the survival and outgrowth of myenteric neurons and NCSCs and is so an appropriate target for neural stem cell treatment.

journal_name

Int J Colorectal Dis

journal_title

International journal of colorectal disease

authors

Hagl CI,Rauch U,Klotz M,Heumüller S,Grundmann D,Ehnert S,Subotic U,Holland-Cunz S,Schäfer KH

doi

10.1007/s00384-012-1411-0

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

817-29

issue

6

eissn

0179-1958

issn

1432-1262

journal_volume

27

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE文献大全
  • Prognostic accuracy of different lymph node staging system in predicting overall survival in stage IV colon cancer.

    abstract：PURPOSE:With emphasis of surgical management, the lymph node (LN) status has been advocated to predict prognosis in colon cancer with distant metastatic. Therefore, we tend to compare the prognostic performance of American Joint Committee on Cancer (AJCC) N-staging relative to lymph node ratio (LNR), log odds of metast...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-019-03486-w

    authors： Han L,Mo S,Xiang W,Li Q,Wang R,Xu Y,Dai W,Cai G

    更新日期：2020-02-01 00:00:00

  • Expression of costimulatory molecule CD80 in colonic dysplasia in ulcerative colitis: an immunosurveillance mechanism against colorectal cancer?

    abstract：BACKGROUND AND AIMS:Ulcerative colitis is an established risk factor for colorectal cancer but dysplasia reports are much more frequent than invasive neoplasm diagnosis. The effective activation of T lymphocytes that provide antitumor surveillance requires the presence of costimulation molecules such as CD80 and CD86 o...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-006-0095-8

    authors： Scarpa M,Behboo R,Angriman I,Cecchetto A,D'Incà R,Termini B,Barollo M,Ruffolo C,Polese L,Sturniolo GC,D'Amico DF

    更新日期：2006-12-01 00:00:00

  • The effects of fast-track surgery on inflammation and immunity in patients undergoing colorectal surgery.

    abstract：OBJECTIVE:The objective of this study is to explore the effects of the fast-track surgery (FTS) program on inflammation and immunity in patients undergoing colorectal surgery. METHODS:From August 2014 to March 2015, a prospective and randomized controlled trial of 230 patients who underwent colorectal surgery was perf...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00384-016-2630-6

    authors： Feng J,Li K,Li L,Wang X,Huang M,Yang J,Hu Y

    更新日期：2016-10-01 00:00:00

  • The effect of oral tolerance on the roles of small intestinal intraepithelial lymphocytes in murine colitis induced by dextran sodium sulfate.

    abstract：BACKGROUNDS AND AIMS:There is increasing evidence that gut-derived intraepithelial lymphocytes have potent cytolytic and immunoregulatory functions, which they use to sustain epithelial integrity. The aims of this study were to investigate the roles of small intestinal intraepithelial lymphocytes (SI-IELs) in oral tole...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-011-1354-x

    authors： Ye Y,Yue M,Jin X,Chen S,Li Y

    更新日期：2012-05-01 00:00:00

  • Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different.

    abstract：BACKGROUND AND AIMS:We previously reported that the sole clinicopathological parameters of carcinomas diagnosed in a single institution in 1975 differed from those in patients diagnosed in 1995. The findings might be compatible with the loss of importance of the microsatellite instability of the carcinogenic pathway. ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-001-0373-4

    authors： Rudzki Z,Zazula M,Okoń K,Stachura J

    更新日期：2002-05-01 00:00:00

  • Skeletal muscle mass and quality as risk factors for postoperative outcome after open colon resection for cancer.

    abstract：BACKGROUND:The prevalence of colorectal cancer in the elderly is increasing and, therefore, surgical interventions with a risk of potential complications are more frequently performed. This study investigated the role of low skeletal muscle mass (sarcopenia), muscle quality, and the sarcopenic obesity as prognostic fac...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-016-2538-1

    authors： Boer BC,de Graaff F,Brusse-Keizer M,Bouman DE,Slump CH,Slee-Valentijn M,Klaase JM

    更新日期：2016-06-01 00:00:00

  • Treatment of rectal prolapse by Delorme's operation.

    abstract：:Rectopexy in the sacral hollow or to the promontory with synthetic material is the most efficient method of reducing and fixing a complete rectal prolapse. However, this distressing condition occurs frequently in elderly patients, often with high operative risk. In these some surgeons have advocated a perineal approac...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/BF01647997

    authors： Houry S,Lechaux JP,Huguier M,Molkhou JM

    更新日期：1987-08-01 00:00:00

  • Preoperative adipocytokines as a predictor of surgical infection after colorectal surgery: a prospective survey.

    abstract：BACKGROUND:Infections are the leading cause of morbidity and mortality after colorectal surgery. Obesity is a well-known risk factor for wound infection, but it does not seem to increase the risk of other infectious complications. The aim of this study was to look for a relationship between the fatty tissue metabolism ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-013-1782-x

    authors： Ortega-Deballon P,Duvillard L,Scherrer ML,Deguelte-Lardière S,Bourredjem A,Petit JM,Bonithon-Kopp C,AGARIC Study group.

    更新日期：2014-01-01 00:00:00

  • Indocyanine green fluorescent imaging on anastomotic leakage in colectomies: a network meta-analysis and systematic review.

    abstract：PURPOSE:The usage of indocyanine green (ICG) dye is commonly associated with decreased anastomotic leakage rates in colectomies. This study aims to perform a network meta-analysis to assess the usage of ICG fluorescence imaging in right-sided colectomies. METHODS:Medline, Embase, Cochrane Trials, CNKI, and WanFang ele...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-020-03723-7

    authors： Mok HT,Ong ZH,Yaow CYL,Ng CH,Buan BJL,Wong NW,Chong CS

    更新日期：2020-12-01 00:00:00

  • NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis.

    abstract：BACKGROUND:Collagenous colitis is a chronic inflammatory bowel disease of unknown origin. In some cases of collagenous colitis, histomorphological features are comparable to other inflammatory bowel diseases. AIM:To assess functional NOD2/CARD15 polymorphisms for the susceptibility to collagenous colitis in a case-con...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-006-0158-x

    authors： Madisch A,Hellmig S,Schreiber S,Bethke B,Stolte M,Miehlke S

    更新日期：2007-04-01 00:00:00

  • Computer-generated surface and tone enhancements to distinguish neoplastic from non-neoplastic colon polyps less than 1 cm in diameter.

    abstract：BACKGROUND AND STUDY AIMS:Computer-generated enhancements, which can highlight the surface and color of a colonic lesion, may be helpful to predict the histology; however, it remains unclear whether this technology can distinguish neoplastic from non-neoplastic colon polyps when the polyps are <1 cm without magnificati...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-011-1319-0

    authors： Han ML,Lee YC,Chen CC,Fang YJ,Lee JY,Lin TL,Lin LW,Tseng PH,Wu MS,Wang HP

    更新日期：2012-03-01 00:00:00

  • Endorectal ultrasound-directed biopsy: a useful technique to detect local recurrence of rectal cancer.

    abstract：AIMS:This study assesses the value of endorectal ultrasound (ERUS)-directed biopsy in detecting local recurrence of rectal cancer. METHODS:We reviewed the records of patients undergoing ERUS by a single surgeon for surveillance after treatment of rectal adenocarcinoma. Lesions suggestive of local recurrence underwent ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-005-0785-7

    authors： Morken JJ,Baxter NN,Madoff RD,Finne CO 3rd

    更新日期：2006-04-01 00:00:00

  • Outcomes of colorectal stents when used as a bridge to curative resection in obstruction secondary to colorectal cancer.

    abstract：BACKGROUND:Up to 25% of colorectal cancers present with bowel obstruction. Metal stents (MS) can provide a bridge to surgery by relieving obstruction and allowing the subject's condition to improve pre-operatively. METHODS:Hospital Episode Statistics (HES) is a database of all NHS funded secondary care episodes in Eng...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-019-03302-5

    authors： Harvey PR,Rees J,Baldwin S,Waheed H,Tanner JR,Evison F,Patel P,Trudgill NJ

    更新日期：2019-07-01 00:00:00

  • Follow-up after colorectal polypectomy: a benefit-risk analysis of German surveillance recommendations.

    abstract：OBJECTIVE:For colorectal screening patients a mean gain of life time was previously calculated of about 30-50 days. Different recommendations for recognising at-risk groups and defining surveillance intervals after an initial finding of colorectal adenomas have been published. However, no benefit-risk analysis regardin...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00384-006-0252-0

    authors： Becker F,Nusko G,Welke J,Hahn EG,Mansmann U

    更新日期：2007-08-01 00:00:00

  • Neurostimulated levator augmentation--a new approach in restoring continence.

    abstract：PURPOSE:Restoration of continence remains a major challenge in patients after abdominoperineal rectal excision (APE) or with end-stage fecal incontinence. A new surgical technique, the neurostimulated levator augmentation, was introduced for pelvic floor augmentation using dynamic graciloplasty in order to restore anor...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-015-2134-9

    authors： Isbert C,Schlegel N,Reibetanz J,Krajinovic K,Schmidt K,Germer CT,Kim M

    更新日期：2015-04-01 00:00:00

  • Radical resection in obstructing colorectal carcinomas.

    abstract：:Emergency resections of obstructing colorectal carcinomas usually involve only limited rather than radical lymphadenectomy, which may contribute to the poor long-term survival of these patients. Thirty patients with ileus due to colorectal cancer have been included in a prospective follow-up study since January 1995. ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s003840050170

    authors： Kruschewski M,Runkel N,Buhr HJ

    更新日期：1998-01-01 00:00:00

  • Peritoneal fluid biomarkers in the detection of colorectal anastomotic leaks: a systematic review.

    abstract：PURPOSE:Anastomotic leak (AL) in colorectal surgery leads to significant morbidity, mortality and poorer oncological outcomes. Diagnosis of AL is frequently delayed as current methods of detection are not 100% sensitive or specific. 'Biomarkers', such as cytokines and markers of ischaemia, from the milieu of the anasto...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00384-017-2799-3

    authors： Wright EC,Connolly P,Vella M,Moug S

    更新日期：2017-07-01 00:00:00

  • Organic colonic lesions in 3,332 patients with suspected irritable bowel syndrome and lacking warning signs, a retrospective case--control study.

    abstract：PURPOSE:The diagnosis of irritable bowel syndrome is symptom based, and colonoscopy is the most direct way to rule out organic colonic diseases. It is controversial on the necessity of colonoscopy for patients with suspected irritable bowel syndrome and lacking alarm features. This study was designed to verify the orga...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-011-1163-2

    authors： Gu HX,Zhang YL,Zhi FC,Jiang B,Huang Y

    更新日期：2011-07-01 00:00:00

  • Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports.

    abstract：PURPOSE:Kras mutations are negative predictors of anti-EGFR therapy, occurring in 40% of colorectal carcinomas (CRCs). Point substitutions in codon 12 or 13 are the most frequent mutations in Kras, but multiple mutations (MMs) in other codons can also develop. Few data exist on MMs with regard to their frequency and th...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章,评审

    doi：10.1007/s00384-011-1238-0

    authors： Macedo MP,Andrade Lde B,Coudry R,Crespo R,Gomes M,Lisboa BC,Aguiar S Jr,Soares FA,Carraro DM,Cunha IW

    更新日期：2011-10-01 00:00:00

  • CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue.

    abstract：BACKGROUND AND AIMS:Pouchitis is the major long-term complication after ileal pouch-anal anastomosis (IPAA) in patients operated on for ulcerative colitis. The cause is unknown, but both the history of ulcerative colitis and increased bacterial concentration are important factors. Chemokines are mediators for the recru...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-003-0500-5

    authors： Helwig U,Gionchetti P,Rizzello F,Lammers K,Kühbacher T,Schreiber S,Baggiolini M,Uguccioni M,Campieri M

    更新日期：2004-03-01 00:00:00

  • Factors associated with complete local excision of small rectal carcinoid tumor.

    abstract：PURPOSE:Although small rectal carcinoid tumors can be treated using local excision, complete resection can be difficult because tumors are located in the submucosal layer. We evaluate the factors associated with pathologically complete local resection of rectal carcinoid tumors. METHODS:Data were analyzed of 161 patie...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-012-1538-z

    authors： Son HJ,Sohn DK,Hong CW,Han KS,Kim BC,Park JW,Choi HS,Chang HJ,Oh JH

    更新日期：2013-01-01 00:00:00

  • Optimal time for single-stage pull-through colectomy in infants with short-segment Hirschsprung disease.

    abstract：OBJECTIVE:Short-segment Hirschsprung disease (HSCR) is the predominant type of HSCR that affects approximately 75% of patients. Whether single-stage endorectal pull-through (ERPT) surgery is appropriate for neonatal patients with HSCR has not been definitively determined. This retrospective cohort study concerning infa...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-018-3179-3

    authors： Zhu T,Sun X,Wei M,Yi B,Zhao X,Wang W,Feng J

    更新日期：2019-02-01 00:00:00

  • Persistent fecal incontinence into adulthood after repair of anorectal malformations.

    abstract：PURPOSE:Persistent fecal incontinence beyond childhood is common in ARM patients. The aim of this study was to analyze a consecutive series of adult patients with persistent incontinence, establish the causes, and evaluate whether further treatment could be offered. METHODS:Forty-four adult ARM patients with reported ...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-018-3220-6

    authors： Danielson J,Karlbom U,Graf W,Wester T

    更新日期：2019-03-01 00:00:00

  • Efficacy of screening using annual fecal immunochemical test alone versus combined with one-time colonoscopy in reducing colorectal cancer mortality: the Akita Japan population-based colonoscopy screening trial (Akita pop-colon trial).

    abstract：PURPOSE:Screening programs using fecal occult blood testing help reduce mortality from colorectal cancer (CRC). Colonoscopy and colonoscopy combined with fecal occult blood testing are considered alternatives with higher sensitivity than fecal tests; however, to our knowledge, randomized controlled trials (RCTs) provid...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-020-03518-w

    authors： Saito H,Kudo SE,Takahashi N,Yamamoto S,Kodama K,Nagata K,Mizota Y,Ishida F,Ohashi Y

    更新日期：2020-05-01 00:00:00

  • Aberrant protein expression and frequent allelic loss of MSH3 in colorectal cancer with low-level microsatellite instability.

    abstract：PURPOSE:High level of microsatellite instability (MSI-H) in colorectal cancer (CRC) is caused by the inactivation of mismatch repair (MMR) genes; however, it is unknown for tumors with low level MSI (MSI-L). The protein complex involving MSH3 preferentially recognizes insertion/deletion loops (IDLs) of two to eight bas...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-011-1408-0

    authors： Plaschke J,Preußler M,Ziegler A,Schackert HK

    更新日期：2012-07-01 00:00:00

  • Does anastomotic leakage impair functional results and quality of life after laparoscopic sphincter-saving total mesorectal excision for rectal cancer? A case-matched study.

    abstract：PURPOSE:Anastomotic leakage (AL) after total mesorectal excision (TME) for rectal cancer is suspected to alter function. However, very few reports have been devoted to this problem. The aim of this study was to assess the influence of AL on function and quality of life (QoL) after laparoscopic TME for cancer. METHODS:...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-014-1833-y

    authors： Mongin C,Maggiori L,Agostini J,Ferron M,Panis Y

    更新日期：2014-04-01 00:00:00

  • Analysis of rectal dynamic and static compliances in patients with irritable bowel syndrome.

    abstract：AIMS:Our aim was to investigate whether the dynamic and static compliances differ between patients with irritable bowel syndrome (IBS) and normal subjects. MATERIALS AND METHODS:Fifty-five IBS patients (age range 20-65 years, mean age 39.0 years, 28 women and 27 men; 36 diarrhea-predominant IBS (IBS-D) patients and 19...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-008-0469-1

    authors： Park JH,Baek YH,Park DI,Kim HJ,Cho YK,Sohn CI,Jeon WK,Kim BI,Rhee PL

    更新日期：2008-07-01 00:00:00

  • A high lymph node yield in colon cancer is associated with age, tumour stage, tumour sub-site and priority of surgery. Results from a prospective national cohort study.

    abstract：AIM:To determine the relation between patient-related and histopathological factors, as well as the influence of national programs for diagnosing and treatment of colon cancer and a lymph node yield (LNY) ≥ 12. METHOD:An analysis was carried out of the LNY in a nationwide Danish cohort treated by curative resection of...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-016-2599-1

    authors： Lykke J,Jess P,Roikjær O,Danish Colorectal Cancer Group.

    更新日期：2016-07-01 00:00:00

  • Microscopic colitides: a single center experience in Mexico.

    abstract：BACKGROUND/AIM:Microscopic colitis is characterized by chronic diarrhea and specific microscopic changes in a macroscopically normal colonic mucosa. In this paper, we report the clinical and histological features of a group of Mexican patients with microscopic colitis. MATERIALS AND METHODS:Patients were identified fr...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s00384-006-0258-7

    authors： Rubio-Tapia A,Martínez-Salgado J,García-Leiva J,Martínez-Benítez B,Uribe M

    更新日期：2007-09-01 00:00:00

  • Anal endosonography for assessment of anal incontinence with a linear probe: relationships with clinical and manometric features.

    abstract：BACKGROUND AND AIMS:This study determined correlations of clinical and manometric features with those of anal endosonography (AES). PATIENTS AND METHODS:Between 1996 and 1999 we examined 58 patients suffering from anal incontinence (AI) by AES using a linear probe and anorectal manometry following a standardized proto...

    journal_title：International journal of colorectal disease

    pub_type： 杂志文章

    doi：10.1007/s003840100354

    authors： Barthet M,Bellon P,Abou E,Portier F,Berdah S,Lesavre N,Orsoni P,Bouvier M,Grimaud JC

    更新日期：2002-03-01 00:00:00