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CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue.

Abstract：

BACKGROUND AND AIMS:Pouchitis is the major long-term complication after ileal pouch-anal anastomosis (IPAA) in patients operated on for ulcerative colitis. The cause is unknown, but both the history of ulcerative colitis and increased bacterial concentration are important factors. Chemokines are mediators for the recruitment of inflammatory cells to the site of inflammation. This study examined the tissue expression of a panel of specific chemokines and the corresponding recruitment of inflammatory cells in IPAA tissue with and without inflammation and after antibiotic treatment. PATIENTS AND METHODS:Biopsy specimens postoperatively from ulcerative colitis patients with IPAA were obtained by endoscopy. Biopsies were taken from 8 patients with noninflamed IPAA and from 14 patients with an episode of acute pouchitis, before and after antibiotic treatment. Biopsies were stained for CD68, CD3, elastase, eotaxin, IP-10, MCP-1, MCP-3, and IL-8 and analyzed by NIH Image analyzer. RESULTS:Expression of IL-8, MCP-1, MCP-3, and IP-10 was significantly higher in pouchitis than normal pouch. The expression of MCP-1, MCP-3 and IP-10 were significantly lower after antibiotic treatment. CONCLUSION:These data support the importance of chemokines for the leukocyte recruitment in pouch tissue during acute pouchitis.

journal_name

Int J Colorectal Dis

journal_title

International journal of colorectal disease

authors

Helwig U,Gionchetti P,Rizzello F,Lammers K,Kühbacher T,Schreiber S,Baggiolini M,Uguccioni M,Campieri M

doi

10.1007/s00384-003-0500-5

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

165-70

issue

2

eissn

0179-1958

issn

1432-1262

journal_volume

19

pub_type

杂志文章

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