Clinicopathologic features and prognostic analysis of MSI-high colon cancer.

Abstract:

PURPOSE:The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. METHODS:Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed. RESULTS:From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p = 0.001), proximally located (76.7% vs. 34.5%, p = 0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p = 0.001) and female predominance (56.7% vs. 30.2%, p = 0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241-0.872, p = 0.017). CONCLUSIONS:Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

journal_name

Int J Colorectal Dis

authors

Lin CC,Lai YL,Lin TC,Chen WS,Jiang JK,Yang SH,Wang HS,Lan YT,Liang WY,Hsu HM,Lin JK,Chang SC

doi

10.1007/s00384-011-1341-2

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

277-86

issue

3

eissn

0179-1958

issn

1432-1262

journal_volume

27

pub_type

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