The role of single-shot metronidazole in the prevention of Clostridium difficile infection following ileostomy reversal surgery.

Abstract:

PURPOSE:Symptomatic infection with Clostridium difficile is strongly linked to antibiotic use and rates are higher for colorectal surgery. In February 2015, trust policy for antibiotic prophylaxis of ileostomy reversal surgery was changed from three doses of metronidazole plus cefuroxime to single-dose metronidazole, in a bid to reduce rates of Clostridium difficile infection. METHODS:A retrospective cohort study was conducted at a single, large hospital trust between February 2014 and February 2016, before and after change in antimicrobial policy. Theatre data, clinical notes and pathology results were all reviewed. Outcome data, patient age, gender, length of operation and hospital stay were extracted. RESULTS:One hundred three patients underwent ileostomy reversal surgery between February 2014 and February 2015. All received cefuroxime together with metronidazole at induction of anaesthesia followed by two further post-operative doses as operative prophylaxis. Ninety-six patients underwent ileostomy reversal surgery between February 2015 and February 2016. All received single-dose metronidazole at induction as prophylaxis. Post-operative diarrhoea was significantly reduced in patients given single-dose metronidazole compared with patients managed with multiple dose, dual antibiotic therapy (32 vs 12.5%, P 0.001). Rates of CDI were also significantly reduced in patients given single-dose metronidazole (6.8 vs 1%, P 0.038). CONCLUSIONS:Single-dose, pre-operative metronidazole is effective at reducing post-operative diarrhoea and CDI in ileostomy reversal surgery compared with multiple-dose cefuroxime plus metronidazole. Metronidazole may be effective as a prophylactic antibiotic against CDI in colonic surgery.

journal_name

Int J Colorectal Dis

authors

Fernandes R,Robinson P,Rangarajan K,Scott S,Angco L

doi

10.1007/s00384-016-2725-0

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

733-736

issue

5

eissn

0179-1958

issn

1432-1262

pii

10.1007/s00384-016-2725-0

journal_volume

32

pub_type

杂志文章
  • Study of histopathologic parameters to define the prognosis of stage II colon cancer.

    abstract:PURPOSE:Stage II colon cancer (CC) represents a challenging scenario for the choice of adjuvant chemotherapy; here, histologic factors need to be weighed up to establish the risk of recurrence. Tumor budding (TB) has recently been indicated as a confident predictor of clinical outcome in CC. Likewise, the presence of p...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-019-03279-1

    authors: Romiti A,Roberto M,Marchetti P,Di Cerbo A,Falcone R,Campisi G,Ferri M,Balducci G,Ramacciato G,Ruco L,Pilozzi E

    更新日期:2019-05-01 00:00:00

  • Characteristic findings on defecography according to reconstruction method and defecatory disorder following sphincter-saving surgery for rectal cancer.

    abstract:BACKGROUND AND AIMS:This study used postoperative defecography to characterize morphological features of defecatory disorders in patients following rectal resection. We also evaluated differences in dynamic defecatory condition depending on reconstruction methods for sphincter-saving surgery. MATERIALS AND METHODS:Sub...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-008-0485-1

    authors: Morihiro M,Koda K,Seike K,Miyauchi H,Miyazaki M

    更新日期:2008-09-01 00:00:00

  • Ambulatory versus conventional laparoscopic appendectomy: a systematic review and meta-analysis.

    abstract:PURPOSE:Ambulatory laparoscopic appendectomy has gained popularity due to the improved understanding of patient selection criteria, the application of enhanced recovery pathways, and the potential for improving healthcare resource utilization. The aim of the review was to compare the morbidity and readmission rates bet...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00384-019-03341-y

    authors: Trejo-Avila M,Cárdenas-Lailson E,Valenzuela-Salazar C,Herrera-Esquivel J,Moreno-Portillo M

    更新日期:2019-08-01 00:00:00

  • Laparoscopic sphincter-preserving surgery (intersphincteric resection) after neoadjuvant imatinib treatment for gastrointestinal stromal tumor (GIST) of the rectum.

    abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) of the rectum are rarely found, and radical surgery such as abdominoperineal resection would be necessary for large rectal GIST. On the other hand, therapy for GIST has changed significantly with the use of imatinib. Neoadjuvant imatinib therapy may reduce tumor size a...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-013-1769-7

    authors: Fujimoto Y,Akiyoshi T,Konishi T,Nagayama S,Fukunaga Y,Ueno M

    更新日期:2014-01-01 00:00:00

  • New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms.

    abstract:PURPOSE:Sound speed correction (SSC) is a non-invasive modality that quantifies the hardness of neoplasms. The aim of our study was to evaluate the usefulness of SSC for the diagnostic accuracy of colorectal neoplasms and to differentiate the depth of invasion. METHODS:Forty colorectal neoplasms, contributed by 40 pat...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03790-w

    authors: Esaki M,Yamamura T,Nakamura M,Maeda K,Sawada T,Mizutani Y,Ishikawa E,Furukawa K,Kawashima H,Hirooka Y,Fujishiro M

    更新日期:2020-10-28 00:00:00

  • Expression and localization of axin 2 in colorectal carcinoma and its clinical implication.

    abstract:PURPOSE:Aberrant activation of the Wnt/β-catenin pathway plays a major role in the development of colorectal carcinoma (CRC). Axin 2 is a key protein of this pathway and is upregulated in CRC. Here, we investigated RNA- and protein expression of axin 2 in CRC tissues at the single cell level. Moreover, the association ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-013-1709-6

    authors: Schaal U,Grenz S,Merkel S,Rau TT,Hadjihannas MV,Kremmer E,Chudasama P,Croner RS,Behrens J,Stürzl M,Naschberger E

    更新日期:2013-11-01 00:00:00

  • CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue.

    abstract:BACKGROUND AND AIMS:Pouchitis is the major long-term complication after ileal pouch-anal anastomosis (IPAA) in patients operated on for ulcerative colitis. The cause is unknown, but both the history of ulcerative colitis and increased bacterial concentration are important factors. Chemokines are mediators for the recru...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-003-0500-5

    authors: Helwig U,Gionchetti P,Rizzello F,Lammers K,Kühbacher T,Schreiber S,Baggiolini M,Uguccioni M,Campieri M

    更新日期:2004-03-01 00:00:00

  • Ileal pouch-anal anastomosis (IPAA): functional outcome after postoperative pelvic sepsis. A prospective study of 100 patients.

    abstract:INTRODUCTION:The ileal pouch-anal anastomosis (IPAA) has become a standard procedure for patients with ulcerative colitis requiring surgical intervention. The technique has greatly improved and, since 1990, all patients at Huddinge University Hospital have been operated on with the double stapled technique. Pelvic seps...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-004-0717-y

    authors: Hallberg H,Ståhlberg D,Akerlund JE

    更新日期:2005-11-01 00:00:00

  • Purse-string skin closure versus linear skin closure techniques in stoma closure: a comprehensive meta-analysis with trial sequential analysis of randomised trials.

    abstract:OBJECTIVES:To compare purse-string skin closure (PSC) and linear skin closure (LSC) techniques in patients undergoing stoma closure METHODS: We conducted a systematic review of literature and meta-analysis of outcomes according to PRISMA statement standards to compare PSC and LSC techniques in stoma closure. Trial sequ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00384-018-3139-y

    authors: Hajibandeh S,Hajibandeh S,Kennedy-Dalby A,Rehman S,Zadeh RA

    更新日期:2018-10-01 00:00:00

  • Erectile and urinary function in men with rectal cancer treated by neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy alone: a randomized trial report.

    abstract:OBJECTIVE:The aim was to evaluate erectile and urinary function of male patients with rectal cancer treated by neoadjuvant (NA) chemoradiotherapy (CRT) or NA chemotherapy only. METHODS:In this prospective randomized trial (ClinicalTrials.gov NCT01211210; "FOWARC"), we included 102 men who received NA therapy for stage...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00384-016-2605-7

    authors: Huang M,Lin J,Yu X,Chen S,Kang L,Deng Y,Zheng J,Luo Y,Wang L,Lan P,Wang J

    更新日期:2016-07-01 00:00:00

  • Screening for the effectiveness of conservative treatment in chronic anal fissure patients using anorectal manometry.

    abstract:PURPOSE:Chemical sphincterotomy (CS) is routinely applied in order to avoid the irreversible anal incontinence associated with the surgical treatment of chronic anal fissure (CAF). However, CS has a lower cure rate than surgery. We developed a screening test (using anal manometry) to separate those patients that are un...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00384-010-0885-x

    authors: Gil J,Luján J,Hernández Q,Gil E,Salom MG,Parrilla P

    更新日期:2010-05-01 00:00:00

  • HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life.

    abstract:PURPOSE:HIV infection and concomitant HPV-associated anal lesions may significantly impact on patients' quality of life (QoL), as they are predicted to have negative effects on health, psyche, and sexuality. MATERIAL AND METHODS:Fifty-two HIV+ patients with HPV-associated anal lesions were enrolled in a survey approac...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03567-1

    authors: Wesselmann P,Schwarze-Zander C,Boesecke C,Rockstroh J,Stoffels B,Vilz TO,Glowka TR,Kalff JC,von Websky MW

    更新日期:2020-06-01 00:00:00

  • Interferon gamma downregulates IL-8 production in primary human colonic epithelial cells without induction of apoptosis.

    abstract:BACKGROUND:In acute or chronic inflammatory bowel disease (IBD) interferon gamma (IFNgamma) is still considered to be an important pro-inflammatory mediator. In the present study we investigated the impact of IFNgamma on interleukin-8 (IL-8) production as a read-out for cell activation in intestinal epithelial cell (IE...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-003-0570-4

    authors: Schlottmann K,Wachs FP,Grossmann J,Vogl D,Maendel M,Falk W,Schölmerich J,Andus T,Rogler G

    更新日期:2004-09-01 00:00:00

  • Risk factors for metachronous adenoma in the residual colon of patients undergoing curative surgery for colorectal cancer.

    abstract:PURPOSE:Adenoma detection in colorectal cancer survivors is poorly characterised with insufficient evidence to inform frequency of surveillance schedule. The aim of this study was to examine adenoma incidence and recurrence in patients who have undergone colorectal cancer resection with curative intent. Survival outcom...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-017-2881-x

    authors: Patel A,Williams N,Parsons N,Ali O,Peters F,Ranat R,Shah J,Spector E,Arasaradnam RP

    更新日期:2017-11-01 00:00:00

  • Technique for laparoscopic autonomic nerve preserving total mesorectal excision.

    abstract::With the introduction of total mesorectal excision (TME) for treatment of rectal cancer, the prognosis of patients with rectal cancer is improved. With this better prognosis, there is a growing awareness about the quality of life of patients after rectal carcinoma. Laparoscopic total mesorectal excision (LTME) for rec...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-005-0009-1

    authors: Breukink SO,Pierie JP,Hoff C,Wiggers T,Meijerink WJ

    更新日期:2006-05-01 00:00:00

  • Microvascular blood flow response in the intestinal wall and the omentum during negative wound pressure therapy of the open abdomen.

    abstract:PURPOSE:Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) compared with other wound therapy techniques. However, the method has occasionally been associated with increased development of intestinal fistulae. The present study measures microvascular blood flow in the...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-011-1317-2

    authors: Hlebowicz J,Hansson J,Lindstedt S

    更新日期:2012-03-01 00:00:00

  • Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study.

    abstract::In hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, more than 90% of the carcinomas show microsatellite instability (MSI) due to a loss of mismatch repair (MMR) function. Although adenomas are very common in HNPCC and demonstrate an accelerated adenoma-carcinoma sequence, data about the prevalence and devel...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-005-0073-6

    authors: German HNPCC Consortium.,Müller A,Beckmann C,Westphal G,Bocker Edmonston T,Friedrichs N,Dietmaier W,Brasch FE,Kloor M,Poremba C,Keller G,Aust DE,Fass J,Büttner R,Becker H,Rüschoff J

    更新日期:2006-10-01 00:00:00

  • Abdominoperineal resection and low anterior resection: comparison of long-term oncologic outcome in matched patients with lower rectal cancer.

    abstract:PURPOSE:The current study aimed to compare the oncologic outcome and pattern of metastasis after abdominoperineal resection (APR) and low anterior resection (LAR) treating lower rectal cancer. METHODS:A total of 804 patients undergoing curative resection (R0) were enrolled prospectively. The APR and LAR groups (n = 40...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-012-1590-8

    authors: Kim JC,Yu CS,Lim SB,Kim CW,Kim JH,Kim TW

    更新日期:2013-04-01 00:00:00

  • Predictive parameters for the clinical course of Crohn's disease: development of a simple and reliable risk model.

    abstract:PURPOSE:The aim of our study was to identify clinical parameters in recently diagnosed Crohn's disease (CD) patients for prediction of their disease course. METHODS:EPIC (Early Predictive parameters of Immunosuppressive therapy in Crohn's disease) is a prospective, observational study in 341 patients with a recent CD ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-019-03369-0

    authors: Stallmach A,Bokemeyer B,Helwig U,Lügering A,Teich N,Fischer I,Rath S,Lang D,Schmidt C,EPIC Study Group.

    更新日期:2019-10-01 00:00:00

  • Preoperative anaemia and perioperative red blood cell transfusion as prognostic factors for recurrence and mortality in colorectal cancer-a Swedish cohort study.

    abstract:PURPOSE:The hypothesis in this study was that anaemia prior to surgery and perioperative red blood cell transfusion increases the risk for recurrence and overall mortality in patients with stages I-III colorectal cancer after abdominal resection with curative intent. METHODS:This is a Swedish single centre retrospecti...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2678-3

    authors: Mörner ME,Edgren G,Martling A,Gunnarsson U,Egenvall M

    更新日期:2017-02-01 00:00:00

  • Confocal chromolaser endomicroscopy: a supplemental diagnostic tool prior to transanal endoscopic microsurgery of rectal tumors?

    abstract:PURPOSE:Due to diagnostic advancements, preoperative staging of rectal tumors was significantly improved. However, difficulties in obtaining accurate results can sometimes be observed in the staging of adenomas and early rectal carcinomas (pT1/2). The aim of this study was to test if confocal chromolaser endomicroscopy...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-009-0813-0

    authors: Borschitz T,Kiesslich R

    更新日期:2010-01-01 00:00:00

  • Traumatic lesions of the rectum.

    abstract::Twenty-two patients treated for rectal trauma between 1975 and 1985 were reviewed. There were 13 males and nine females, of mean age 38 years (18-72 years). Causes included gunshot (2), sexual trauma (8), road accident (5), impalement (5), polypectomy (2). Two patients died, giving a treatment mortality of 9%. Cases w...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF01648441

    authors: Marti MC,Morel P,Rohner A

    更新日期:1986-07-01 00:00:00

  • Disease severity and treatment requirements in familial inflammatory bowel disease.

    abstract:PURPOSE:Several studies demonstrate an increased prevalence and concordance of inflammatory bowel disease among the relatives of patients. Other studies suggest that genetic influence is over-estimated. The aims of this study are to evaluate the phenotypic expression and the treatment requirements in familial inflammat...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-017-2791-y

    authors: Ballester MP,Martí D,Tosca J,Bosca-Watts MM,Sanahuja A,Navarro P,Pascual I,Antón R,Mora F,Mínguez M

    更新日期:2017-08-01 00:00:00

  • Clinical results after restorative proctocolectomy without diverting ileostomy for ulcerative colitis.

    abstract:BACKGROUND AND AIMS:This study evaluated the postoperative complications and clinical results of restorative proctocolectomy without diverting ileostomy for ulcerative colitis. PATIENTS AND METHODS:One hundred selected patients had a hand-sewn ileal J-pouch anal anastomosis with mucosectomy using an ultrasonically act...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-003-0538-4

    authors: Ikeuchi H,Shoji Y,Kusunoki M,Yanagi H,Noda M,Yamamura T

    更新日期:2004-05-01 00:00:00

  • Safety of mFOLFOX6/XELOX as adjuvant chemotherapy after curative resection of stage III colon cancer: phase II clinical study (The FACOS study).

    abstract:PURPOSE:Adjuvant chemotherapy with oxaliplatin combined with a fluoropyrimidine derivative is widely accepted as standard therapy for patients with stage III colon cancer, since few clinical data are available for Japanese patients. The FACOS trial investigated the tolerability of modified FOLFOX6 (mFOLFOX6) and XELOX ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-2979-9

    authors: Kosugi C,Koda K,Ishibashi K,Yoshimatsu K,Tanaka S,Kato R,Kato H,Oya M,Narushima K,Mori M,Shuto K,Ishida H

    更新日期:2018-06-01 00:00:00

  • Neurostimulated levator augmentation--a new approach in restoring continence.

    abstract:PURPOSE:Restoration of continence remains a major challenge in patients after abdominoperineal rectal excision (APE) or with end-stage fecal incontinence. A new surgical technique, the neurostimulated levator augmentation, was introduced for pelvic floor augmentation using dynamic graciloplasty in order to restore anor...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-015-2134-9

    authors: Isbert C,Schlegel N,Reibetanz J,Krajinovic K,Schmidt K,Germer CT,Kim M

    更新日期:2015-04-01 00:00:00

  • NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis.

    abstract:BACKGROUND:Collagenous colitis is a chronic inflammatory bowel disease of unknown origin. In some cases of collagenous colitis, histomorphological features are comparable to other inflammatory bowel diseases. AIM:To assess functional NOD2/CARD15 polymorphisms for the susceptibility to collagenous colitis in a case-con...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-006-0158-x

    authors: Madisch A,Hellmig S,Schreiber S,Bethke B,Stolte M,Miehlke S

    更新日期:2007-04-01 00:00:00

  • Management of rectourethral fistulas in Crohn's disease.

    abstract::We report the thirteenth case of a recto-urethral fistula in Crohn's disease. The patient, a 37-year-old white male, had a 20-year history of intestinal Crohn's disease and had undergone numerous bowel resections. His symptoms were fecaluria, urorrhea and passing of urine from an orifice just outside the base of the s...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/BF00346215

    authors: Santoro GA,Bucci L,Frizelle FA

    更新日期:1995-01-01 00:00:00

  • Effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial.

    abstract:PURPOSE:We evaluated the efficacy of oral administration of a mixture of diosmin, coumarin glycosides, and Centella asiatica (Venoplant®) in preventing bleeding, pain, and thrombosis of internal and external hemorrhoids after stapled anopexy (SA). METHODS:SA was conducted in 182 patients with third-degree hemorrhoids....

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00384-016-2698-z

    authors: Schiano di Visconte M,Nicolì F,Del Giudice R,Cipolat Mis T

    更新日期:2017-03-01 00:00:00

  • Spatiotemporal expression of Wnt5a during the development of the hindgut and anorectum in human embryos.

    abstract:PURPOSE:The aim of the study was to determine the spatiotemporal expression of Wnt5a during hindgut and anorectum development in human embryos and to explore the possible role of Wnt5a during the morphogenesis of the human hindgut and anorectum. MATERIALS AND METHODS:The embryos (n = 107) were sectioned serially and s...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-011-1191-y

    authors: Li FF,Zhang T,Bai YZ,Yuan ZW,Wang WL

    更新日期:2011-08-01 00:00:00