当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF COLORECTAL DISEASE期刊下所有文献 > Spatiotemporal expression of Wnt5a during the development of the hindgut and anorectum in human embryos.

Spatiotemporal expression of Wnt5a during the development of the hindgut and anorectum in human embryos.

Abstract：

PURPOSE:The aim of the study was to determine the spatiotemporal expression of Wnt5a during hindgut and anorectum development in human embryos and to explore the possible role of Wnt5a during the morphogenesis of the human hindgut and anorectum. MATERIALS AND METHODS:The embryos (n = 107) were sectioned serially and sagittally, using Wnt5a immunohistochemical staining on the caudal midline from the 4th-9th weeks of gestation. RESULTS:From the 4th-7th week of gestation, the Wnt5a-positive cells were mainly located on the epithelium of the apical urorectal septum, hindgut, and cloacal membrane. After the anorectum and the urogenital sinus (UGS) opened to the amniotic cavity during the 7th week, the Wnt5a-positive cells disappeared and remained negative up to the 9th week on the epithelium of the anal canal. CONCLUSIONS:The expression of Wnt5a was constantly active during human hindgut and anorectum development and disappeared after the anus formed, suggesting that Wnt5a plays an important role in human hindgut and anorectal morphogenesis.

journal_name

Int J Colorectal Dis

journal_title

International journal of colorectal disease

authors

Li FF,Zhang T,Bai YZ,Yuan ZW,Wang WL

doi

10.1007/s00384-011-1191-y

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

983-8

issue

8

eissn

0179-1958

issn

1432-1262

journal_volume

26

pub_type

杂志文章

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