Abstract:
INTRODUCTION:Inflammatory bowel disease (IBD) patients are at greater risk of developing colorectal cancer (CRC). Detection of precursor dysplasia is important for cancer prevention. Recent guidelines recommend dye chromoendoscopy (DCE) as the preferred method for dysplasia detection. Universal adoption of DCE is time-consuming and may limit endoscopy access. The benefit of universal application of the guidelines is unclear. We compared high-definition white-light colonoscopy (HD-WLC) with DCE for dysplasia detection in IBD patients. METHODS:We conducted a retrospective case-control study of adult IBD patients undergoing dysplasia surveillance between September 1, 2015, and February 1, 2020. DCE cases were matched to HD-WLC in a 1:1 ratio for gender, IBD diagnosis, and age. DCE patients were considered high risk for colorectal cancer by the referring provider. RESULTS:A total of 187 subjects were enrolled. Majority were males, were Caucasian, and had longstanding IBD (primarily ulcerative colitis). Baseline characteristics were similar between the two groups, except for history of surgery, duration of IBD, and history of dysplasia. There was no significant difference in dysplasia detection between DCE and HD-WLC (10.2% vs 6.7%, p = 0.39). More polyps were detected in the DCE arm compared with the HD-WLC group (1.35 vs 0.80, p = 0.018), but adenoma detection rate was not statistically different between the two groups (10.2% vs 9.0%, p = 0.31). Mean withdrawal time was longer in the DCE group (24.6 min vs 15.4, p < 0.001). CONCLUSIONS:There were no differences in dysplasia detection using DCE compared with HD-WLC, although withdrawal times were longer with DCE.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Clarke K,Kang M,Gorrepati VS,Stine JG,Tinsley A,Williams E,Moyer M,Coates Mdoi
10.1007/s00384-020-03719-3subject
Has Abstractpub_date
2020-12-01 00:00:00pages
2301-2307issue
12eissn
0179-1958issn
1432-1262pii
10.1007/s00384-020-03719-3journal_volume
35pub_type
杂志文章abstract:PURPOSE:Tumour-associated macrophages have been shown to promote proliferation, angiogenesis and metastasis in several carcinomas. The effect on colon cancer has not yet been clarified. Furthermore, Kupffer cells in the liver might initiate the formation of metastases by directly binding tumour cells. METHODS:An ortho...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-013-1703-z
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Computed tomography (CT) with intravenous contrast is the gold standard for diagnosing diverticulitis. Published results concerning follow-up colonoscopy after an episode of acute diverticulitis to rule out cancer are conflicting. This study aimed to evaluate the risk of underlying colonic malignancy in pati...
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abstract:BACKGROUND:To clarify the risk factors of lateral pelvic lymph node (LPLN) metastasis of rectal cancer, we examined associations between LPLN status and clinicopathological factors including LPLN status diagnosed by computed tomography (CT). METHODS:We reviewed a total of 210 patients with advanced rectal cancer, of w...
journal_title:International journal of colorectal disease
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更新日期:2009-09-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 已发布勘误
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更新日期:2020-04-20 00:00:00
abstract:BACKGROUND:The impact of postoperative complications (POCs) on the long-term prognosis of patients with colorectal carcinoma was analysed with respect to their severity according to the Clavien-Dindo classification (CDC). METHODS:The prospectively collected data of 2158 patients who underwent curative resection of a c...
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更新日期:2017-05-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:2020-10-28 00:00:00
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更新日期:2020-10-21 00:00:00
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journal_title:International journal of colorectal disease
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doi:10.1007/s00384-009-0769-0
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journal_title:International journal of colorectal disease
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更新日期:1986-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
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更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Whether race affects the natural history of Crohn's disease is a matter of debate. The aim of the current study was to evaluate the differences in surgical outcomes between African-American (AA) and Caucasian (C) Crohn's patients undergoing surgery at a tertiary care referral center. METHODS:W...
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pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00384-019-03400-4
更新日期:2019-11-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-04-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2006-09-01 00:00:00
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更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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