Abstract:
:Epidemiological studies provide strong evidence to confirm the correlation between cigarette smoking and inflammatory bowel diseases. This relationship is proved to be positive in Crohn's disease and negative in ulcerative colitis. What in smoking alters the course of inflammatory bowel diseases is still a mystery. Different smoking parts have different and may be opponent actions. Smoking has dual effects. Some of its activities are, sometimes, constructive as they are working in an antagonistic manner to the mechanism of the disease, such as reducing rectal blood flow and accordingly less recruitments of inflammatory mediators to the area of inflammation, enhancement of mucosal production, and consequently, strengthening the membranes, and inhibition of pro-inflammatory mediators' liberation and activity in subjects with ulcerative colitis. Yet the outcome of smoking actions may be affected by the existence of other cofactors. Odd factors, such as shortage of zinc in subjects with Crohn's disease, may facilitate liberation of pro-inflammatory mediators and their activities and accordingly exacerbates symptoms.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
El-Tawil AMdoi
10.1007/s00384-010-0925-6subject
Has Abstractpub_date
2010-06-01 00:00:00pages
671-80issue
6eissn
0179-1958issn
1432-1262journal_volume
25pub_type
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:1992-06-01 00:00:00
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:2010-09-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:2011-11-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2000-02-01 00:00:00
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更新日期:2019-03-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00