Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma.

Abstract:

PURPOSE:Serological tumor markers are routinely used to monitor tumor onset and progression. In colorectal carcinoma (CRC), the carcinoembryonic antigen (CEA) is roughly elevated in 50% of patients at initial diagnosis. Soluble ICAM-1 (sICAM-1) is elevated in different cancers. The aim of this study was to evaluate the prognostic relevance of sICAM-1 combined with CEA in patients with CRC. METHODS:In blood samples of 297 CRC patients, sICAM-1 was determined by ELISA and CEA by microparticle enzyme immunoassay the day before oncologic resection. Separation in patients with sICAM-1high and sICAM-1low was performed by minimum p value approach; separation in CEA normal and elevated was performed according to the established diagnostic cutoff. Clinical data were obtained from the prospective collected data from the Erlangen Registry for Colorectal Carcinomas. RESULTS:Cancer-related 5-year survival rate of patients with sICAM-1low (< 290 ng/ml, n = 208) was significantly increased (83.4%) as compared to that of patients with sICAM-1high (≥ 290 ng/ml, n = 89) (66.2%; p < 0.001). Patients with normal CEA concentrations (n = 199; 90.8%) showed a significantly (p < 0.001) improved cancer-related 5-year survival rate compared to patients with elevated CEA concentrations (n = 98; 52.1%). Moreover, high sICAM-1 was an independent risk factor (hazard ratio 1.6) in multivariate analysis. Of note, increased sICAM-1 levels, either within normal or within elevated CEA, allowed to identify high-risk subgroups, both for overall (p < 0.001) and cancer-related survival (p < 0.001). CONCLUSION:Application of a novel risk score combining CEA/sICAM-1 serum concentrations allows the identification of high-risk groups for poor survival in CRC patients.

journal_name

Int J Colorectal Dis

authors

Schellerer VS,Langheinrich MC,Zver V,Grützmann R,Stürzl M,Gefeller O,Naschberger E,Merkel S

doi

10.1007/s00384-018-3198-0

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

309-317

issue

2

eissn

0179-1958

issn

1432-1262

pii

10.1007/s00384-018-3198-0

journal_volume

34

pub_type

杂志文章
  • NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis.

    abstract:BACKGROUND:Collagenous colitis is a chronic inflammatory bowel disease of unknown origin. In some cases of collagenous colitis, histomorphological features are comparable to other inflammatory bowel diseases. AIM:To assess functional NOD2/CARD15 polymorphisms for the susceptibility to collagenous colitis in a case-con...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-006-0158-x

    authors: Madisch A,Hellmig S,Schreiber S,Bethke B,Stolte M,Miehlke S

    更新日期:2007-04-01 00:00:00

  • Indocyanine green fluorescent imaging on anastomotic leakage in colectomies: a network meta-analysis and systematic review.

    abstract:PURPOSE:The usage of indocyanine green (ICG) dye is commonly associated with decreased anastomotic leakage rates in colectomies. This study aims to perform a network meta-analysis to assess the usage of ICG fluorescence imaging in right-sided colectomies. METHODS:Medline, Embase, Cochrane Trials, CNKI, and WanFang ele...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03723-7

    authors: Mok HT,Ong ZH,Yaow CYL,Ng CH,Buan BJL,Wong NW,Chong CS

    更新日期:2020-12-01 00:00:00

  • Adaptive cytoprotection against acetic acid induced colonic injury in rats.

    abstract:BACKGROUND AND AIMS:The phenomenon of prostaglandin dependent adaptive cytoprotection has been well established in the stomach and duodenum but not in the colon. This study investigated whether it also occurs in the colon. METHODS:Fisher rats received intracolonic administration (0.5 ml) of saline or acetic acid at lo...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840100332

    authors: Kono T,Yoneda M,Ohara K,Ayabe T,Chisato N,Kohgo Y,Kasai S,Terano A,Taché Y

    更新日期:2001-11-01 00:00:00

  • Safety of mFOLFOX6/XELOX as adjuvant chemotherapy after curative resection of stage III colon cancer: phase II clinical study (The FACOS study).

    abstract:PURPOSE:Adjuvant chemotherapy with oxaliplatin combined with a fluoropyrimidine derivative is widely accepted as standard therapy for patients with stage III colon cancer, since few clinical data are available for Japanese patients. The FACOS trial investigated the tolerability of modified FOLFOX6 (mFOLFOX6) and XELOX ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-2979-9

    authors: Kosugi C,Koda K,Ishibashi K,Yoshimatsu K,Tanaka S,Kato R,Kato H,Oya M,Narushima K,Mori M,Shuto K,Ishida H

    更新日期:2018-06-01 00:00:00

  • Soiling: anorectal function and results of treatment.

    abstract::Forty-five patients with soiling but without faecal incontinence were evaluated by means of anorectal function investigations (anal manometry, rectal capacity and saline infusion test). The causes of soiling and the effect of treatment on both soiling and anorectal function were studied. The results were compared with...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF01648548

    authors: Felt-Bersma RJ,Janssen JJ,Klinkenberg-Knol EC,Hoitsma HF,Meuwissen SG

    更新日期:1989-01-01 00:00:00

  • Intensive surveillance following curative treatment of colorectal cancer allows effective treatment of recurrence even if limited to 4 years.

    abstract:BACKGROUND:Current evidence suggests a survival benefit to post-operative surveillance following curative colorectal cancer resection; however, there is still no consensus on the optimal duration and form. OBJECTIVES:The objective is to prospectively audit outcomes of an intensive colorectal cancer follow-up scheme fo...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-015-2356-x

    authors: Adams K,Higgins L,Beazley S,Papagrigoriadis S

    更新日期:2015-12-01 00:00:00

  • D3 lymph node dissection reduces recurrence after primary resection for elderly patients with colon cancer.

    abstract:PURPOSE:The favorable oncological impact of D3 lymph node dissection after colon cancer surgery has been described previously. However, D3 lymph node dissection is potentially more invasive than conventional D2 lymph node dissection. The oncological merit of D3 lymph node dissection in elderly patients with colon cance...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-03233-7

    authors: Numata M,Sawazaki S,Aoyama T,Tamagawa H,Sato T,Saeki H,Saigusa Y,Taguri M,Mushiake H,Oshima T,Yukawa N,Shiozawa M,Rino Y,Masuda M

    更新日期:2019-04-01 00:00:00

  • A single institution's long-term follow-up of patients with pathological complete response in locally advanced rectal adenocarcinoma following neoadjuvant chemoradiotherapy.

    abstract:PURPOSE:This paper aimed to study the long term follow-up of patients with primary rectal adenocarcinoma receiving neoadjuvant chemoradiotherapy who obtained a pathological complete response (pCR) and identify factors predicting complete response. METHODS:Retrospective review of notes, histology, pre-operative full bl...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2712-5

    authors: Runau F,Collins A,Fenech GA,Ford E,Dimitriou N,Chaudhri S,Yeung JM

    更新日期:2017-03-01 00:00:00

  • Dynamic magnetic resonance imaging evaluation of pelvic reconstruction with porcine dermal collagen mesh following extra-levator abdominoperineal excision for primary rectal cancer.

    abstract:PURPOSE:Extra-levator abdominoperineal excision for rectal cancer includes resection of the levator ani muscle and therefore makes pelvic reconstruction advisable. The aim of our study was to evaluate morphologic and functional long-term results of pelvic floor augmentation with porcine dermal collagen mesh by dynamic ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-015-2169-y

    authors: Dinnewitzer A,Meissnitzer M,Meissnitzer T,Nawara C,Augschöll C,Buchner S,Mayer F,Öfner D

    更新日期:2015-04-01 00:00:00

  • Analysis of rectal dynamic and static compliances in patients with irritable bowel syndrome.

    abstract:AIMS:Our aim was to investigate whether the dynamic and static compliances differ between patients with irritable bowel syndrome (IBS) and normal subjects. MATERIALS AND METHODS:Fifty-five IBS patients (age range 20-65 years, mean age 39.0 years, 28 women and 27 men; 36 diarrhea-predominant IBS (IBS-D) patients and 19...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-008-0469-1

    authors: Park JH,Baek YH,Park DI,Kim HJ,Cho YK,Sohn CI,Jeon WK,Kim BI,Rhee PL

    更新日期:2008-07-01 00:00:00

  • Rectocele: pathogenesis and surgical management.

    abstract:BACKGROUND:Rectocele is a common finding in patients with intractable evacuatory disorders. Although much rectocele surgery is conducted by gynecologists en passant with other forms of vaginal surgery, many reports lack appreciation of the importance of coincident anorectal symptoms, and do not report functional and cl...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-003-0478-z

    authors: Zbar AP,Lienemann A,Fritsch H,Beer-Gabel M,Pescatori M

    更新日期:2003-09-01 00:00:00

  • The role of obesity on the recurrence of pilonidal sinus disease in patients, who were treated by excision and Limberg flap transposition.

    abstract::Recurrence of pilonidal sinus disease after surgical intervention is not a very rare problem although sophisticated reconstruction procedures have been developed. Recurrence is thought to be related to the anatomical status of the patients, i.e., depth of the intergluteal groove. Obese patients have deeper interglutea...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840000212

    authors: Cubukçu A,Gönüllü NN,Paksoy M,Alponat A,Kuru M,Ozbay O

    更新日期:2000-06-01 00:00:00

  • The role of oral antibiotics prophylaxis in prevention of surgical site infection in colorectal surgery.

    abstract:BACKGROUND:Surgical site infection (SSI) continues to be a challenge in colorectal surgery. Over the years, various modalities have been used in an attempt to reduce SSI risk in elective colorectal surgery, which include mechanical bowel preparation before surgery, oral antibiotics and intravenous antibiotic prophylaxi...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00384-016-2662-y

    authors: Koullouros M,Khan N,Aly EH

    更新日期:2017-01-01 00:00:00

  • Factors affecting lymph node yield from patients undergoing colectomy for cancer.

    abstract:PURPOSE:Lymph node (LN) yield is a critical component of colon cancer staging and is often a surrogate for quality assessment in surgery. We investigated the impact of pathologists' training on LN harvest. METHODS:This is a retrospective review on 137 patients undergoing elective colectomy for adenocarcinoma at a sing...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-011-1240-6

    authors: Bamboat ZM,Deperalta D,Dursun A,Berger DL,Bordeianou L

    更新日期:2011-09-01 00:00:00

  • Comparison of short- and long-term outcomes after extralevator abdominoperineal excision and standard abdominoperineal excision for rectal cancer: a systematic review and meta-analysis.

    abstract:PURPOSE:Whether the introduction of extralevator abdominoperineal excision (ELAPE) improves survival and safety remains controversial. We conducted a systematic review and meta-analysis of all comparative studies to define the efficacy and safety of ELAPE and standard abdominoperineal excision (APE). MATERIALS AND MET...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00384-013-1793-7

    authors: Yu HC,Peng H,He XS,Zhao RS

    更新日期:2014-02-01 00:00:00

  • A simple quality of life questionnaire for patients with faecal incontinence.

    abstract:INTRODUCTION:A simple quality of life questionnaire was designed to triage patients with faecal incontinence to the most appropriate level of support, investigation and treatment. METHOD:A questionnaire was developed to include a 'symptom' score, similar in content to St Mark's questionnaire and a 'bothersome' score. ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-009-0769-0

    authors: Krysa J,Lyons M,Williams AB

    更新日期:2009-10-01 00:00:00

  • Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats.

    abstract:OBJECTIVE/BACKGROUND:Signals for the expression of the peptide growth factors epidermal growth factor and transforming growth factor-alpha (TGFalpha) in the gastrointestinal mucosa are largely unknown. We have shown earlier that extrinsic afferents in the gastrointestinal tract induce TGFalpha expression in colonic muc...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-009-0856-2

    authors: Bulut K,Felderbauer P,Hoeck K,Schmidt WE,Hoffmann P

    更新日期:2010-03-01 00:00:00

  • Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomas.

    abstract:BACKGROUND AND AIMS:MMP-7, a member of the matrix metalloproteinase family, is believed to play a significant role in the growth and proliferation of colon cancer cells. The aim of this study was to evaluate MMP-7 gene expression in comparison with MMP-1, MMP-3, and MMP-13 in patients with resectable rectal and colon c...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-004-0592-6

    authors: Roeb E,Arndt M,Jansen B,Schumpelick V,Matern S

    更新日期:2004-11-01 00:00:00

  • New approach to large haemorrhoidal prolapse: double stapled haemorrhoidopexy.

    abstract:PURPOSE:To verify if in large haemorrhoidal prolapse (independently from the degree) in patients with no symptoms of obstructed defaecation syndrome, the use of a stapled hemorrhoidopexy variant, comprising a double stapler haemorrhoidopexy (DSH), makes it possible to reduce the percentage of failures or relapses and t...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-009-0750-y

    authors: Naldini G,Martellucci J,Talento P,Caviglia A,Moraldi L,Rossi M

    更新日期:2009-12-01 00:00:00

  • Laparoscopic surgery in rectal cancer: a retrospective analysis.

    abstract:BACKGROUND:Laparoscopic resection for the cure of rectal cancer is still a matter of debate. Laparoscopic approach is more complex and with a long learning curve, which may results in an increase in morbidity and mortality. This study aimed to retrospectively analyze the impact of laparoscopic resection for rectal canc...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-009-0789-9

    authors: Hiep PN,Vu PA,Thien HH

    更新日期:2009-12-01 00:00:00

  • Laparoscopic surgery of benign entero-vesical or entero-vaginal fistulae.

    abstract:PURPOSE:Entero-vesical or entero-vaginal fistulae (EVF) are an uncommon septic complication mainly of diverticular disease. The fistulae are usually situated within extensive and dense inflammatory masses occluding the entrance of the pelvis. There are still some controversies regarding laparoscopic feasibility and tre...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-015-2395-3

    authors: Kraemer M,Kara D

    更新日期:2016-01-01 00:00:00

  • Accuracy of colonoscopy in localisation of colorectal cancer.

    abstract::An audit was performed of 77 patients with a single colorectal cancer visualised and sited before surgery by colonoscopic examination. The site of the cancer described at colonoscopy was compared with the actual site found at laparotomy. Six significant errors in preoperative localisation were encountered, when a chan...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF00298535

    authors: Hancock JH,Talbot RW

    更新日期:1995-01-01 00:00:00

  • Robotic rectal cancer surgery in obese patients may lead to better short-term outcomes when compared to laparoscopy: a comparative propensity scored match study.

    abstract:PURPOSE:Laparoscopic rectal surgery in obese patients is technically challenging. The technological advantages of robotic instruments can help overcome some of those challenges, but whether this translates to superior short-term outcomes is largely unknown. The aim of this study is to compare the short-term surgical ou...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-3030-x

    authors: Panteleimonitis S,Pickering O,Abbas H,Harper M,Kandala N,Figueiredo N,Qureshi T,Parvaiz A

    更新日期:2018-08-01 00:00:00

  • Metachronous cancer development in patients with sporadic colorectal adenomas-multivariate risk model with independent and combined value of hTERT and survivin.

    abstract:BACKGROUND AND AIMS:Accurate, long-term risk predictors for colorectal cancer development in patients with sporadic adenomas are lacking. We sought to validate biomarkers predictive of metachronous colorectal cancer (mCRC) in patients with sporadic colorectal adenomas, using 374 consecutive patients from a large define...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-007-0424-6

    authors: Søreide K,Gudlaugsson E,Skaland I,Janssen EA,Van Diermen B,Körner H,Baak JP

    更新日期:2008-04-01 00:00:00

  • Colorectal carcinoma in Poland in 1975 and 1995: not only more, but also different.

    abstract:BACKGROUND AND AIMS:We previously reported that the sole clinicopathological parameters of carcinomas diagnosed in a single institution in 1975 differed from those in patients diagnosed in 1995. The findings might be compatible with the loss of importance of the microsatellite instability of the carcinogenic pathway. ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-001-0373-4

    authors: Rudzki Z,Zazula M,Okoń K,Stachura J

    更新日期:2002-05-01 00:00:00

  • Purse-string skin closure versus linear skin closure techniques in stoma closure: a comprehensive meta-analysis with trial sequential analysis of randomised trials.

    abstract:OBJECTIVES:To compare purse-string skin closure (PSC) and linear skin closure (LSC) techniques in patients undergoing stoma closure METHODS: We conducted a systematic review of literature and meta-analysis of outcomes according to PRISMA statement standards to compare PSC and LSC techniques in stoma closure. Trial sequ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00384-018-3139-y

    authors: Hajibandeh S,Hajibandeh S,Kennedy-Dalby A,Rehman S,Zadeh RA

    更新日期:2018-10-01 00:00:00

  • Aberrant protein expression and frequent allelic loss of MSH3 in colorectal cancer with low-level microsatellite instability.

    abstract:PURPOSE:High level of microsatellite instability (MSI-H) in colorectal cancer (CRC) is caused by the inactivation of mismatch repair (MMR) genes; however, it is unknown for tumors with low level MSI (MSI-L). The protein complex involving MSH3 preferentially recognizes insertion/deletion loops (IDLs) of two to eight bas...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-011-1408-0

    authors: Plaschke J,Preußler M,Ziegler A,Schackert HK

    更新日期:2012-07-01 00:00:00

  • Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue.

    abstract:BACKGROUND AND AIMS:Malignant cells often exhibit perturbations in the pattern of cytosine methylation. Hypermethylation of CpG islands has been extensively documented, but genome-wide hypomethylation is also a common feature of malignant cells. The bulk of cytosine methylation in the mammalian genome occurs on repetit...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-003-0539-3

    authors: Suter CM,Martin DI,Ward RL

    更新日期:2004-03-01 00:00:00

  • Prospective randomised clinical trial of single versus double purse-string stapled mucosectomy in the treatment of prolapsed haemorrhoids.

    abstract:BACKGROUND AND AIMS:Despite the excellent results published on circular stapled mucosectomy (CSM), there is still some concern about the application of PPH-33 in the advanced haemorrhoidal disease, where a major prolapse may lead to insufficient resection and ensuing early recurrence. This study is aimed at comparing t...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00384-004-0720-3

    authors: Pérez-Vicente F,Arroyo A,Serrano P,Candela F,Sánchez A,Calpena R

    更新日期:2006-01-01 00:00:00

  • Long-term outcomes after treatment for T1 colorectal carcinoma.

    abstract:PURPOSE:Long-term outcomes of patients with T1 colorectal carcinoma (CRC) treated by endoscopic resection (ER) or surgical resection are unclear in relation to the curative criteria in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines. The aim of this study was to retrospectively compare the lo...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-015-2473-6

    authors: Asayama N,Oka S,Tanaka S,Ninomiya Y,Tamaru Y,Shigita K,Hayashi N,Egi H,Hinoi T,Ohdan H,Arihiro K,Chayama K

    更新日期:2016-03-01 00:00:00