Abstract:
BACKGROUND:The prognostic significance of anti-53 autoantibody in colorectal cancer (CRC) patients is unclear due to measurement of overall rather than disease-specific survival and generally short follow-up periods in many studies. We aim to investigate prognostic significance of anti-p53 auto-antibodies in a study with long-term follow-up (minimum 5 years). METHODS:ELISA for anti-p53 autoantibody was assayed in serum from 92 patients with CRC and 28 controls. RESULTS:Anti-p53 autoantibody was found in 20 patients (21.7%) and none of the controls. No difference in Dukes' (A/B vs. C/D), Stage (I/II vs. III/IV), T1/2 vs. T3/4, N0 vs. N1/2, M0 vs. M1, poor vs. well/moderate differentiation and proximal vs. distal CRC was observed. Median overall survival was 62 months and median disease-specific survival was 73 months. Dukes' C/D, Stage III/IV, N1/2 and M1 were associated with poor disease-specific survival in univariate analysis. Stage III/IV was an independent prognostic factor in overall and disease-free survival in multivariate analysis. Anti-p53 autoantibody sero-positivity did not influence overall (p = 0.980) or disease-specific survival (p = 0.874). Median overall survival in anti-p53 autoantibody positive patients was 62 months vs. 60 months in anti-53 autoantibody negative patients. Median disease-specific survival in anti-p53 autoantibody positive patients was 73 months vs. 82 months. CONCLUSION:Anti-p53 autoantibody is not related to clinical parameters of CRC and has no prognostic significance in long-term follow-up.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Suppiah A,Alabi A,Madden L,Hartley JE,Monson JR,Greenman Jdoi
10.1007/s00384-008-0458-4subject
Has Abstractpub_date
2008-06-01 00:00:00pages
595-600issue
6eissn
0179-1958issn
1432-1262journal_volume
23pub_type
杂志文章abstract::Polyps in the stomach and duodenum are frequently found in familial adenomatous polyposis. Cancer arising from some of these polyps may be an important cause of death in patients who have had large bowel resections. This study aims to determine the nature and distribution of foregut polyps in Chinese patients. Twenty-...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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更新日期:1998-01-01 00:00:00
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,随机对照试验
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更新日期:2011-05-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:2012-03-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Collagenous colitis is a chronic inflammatory bowel disease of unknown origin. In some cases of collagenous colitis, histomorphological features are comparable to other inflammatory bowel diseases. AIM:To assess functional NOD2/CARD15 polymorphisms for the susceptibility to collagenous colitis in a case-con...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-006-0158-x
更新日期:2007-04-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00384-010-1128-x
更新日期:2011-05-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-008-0595-9
更新日期:2009-01-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-009-0769-0
更新日期:2009-10-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
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journal_title:International journal of colorectal disease
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更新日期:2011-09-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-006-0135-4
更新日期:2007-03-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/BF01648441
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Whether race affects the natural history of Crohn's disease is a matter of debate. The aim of the current study was to evaluate the differences in surgical outcomes between African-American (AA) and Caucasian (C) Crohn's patients undergoing surgery at a tertiary care referral center. METHODS:W...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
doi:10.1007/s00384-007-0362-3
更新日期:2008-01-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00