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Synthesis of hybrid acetogenins, alpha,beta-unsaturated-gamma-lactone-free nitrogen-containing heterocyclic analogues, and their cytotoxicity against human cancer cell lines.

Abstract：

:A series of alpha,beta-unsaturated-gamma-lactone-free nitrogen-containing heterocyclic analogues of solamin, a natural mono-THF acetogenin, have been synthesized and their cytotoxicity was investigated against 39 tumor cell lines. One of them, 1-methylpyrazol-5-yl derivative, showed selective increase of cytotoxicity against NCI-H23 with 80 times higher potency than solamin.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kojima N,Fushimi T,Maezaki N,Tanaka T,Yamori T

doi

10.1016/j.bmcl.2008.01.057

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

1637-41

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00074-7

journal_volume

18

pub_type

杂志文章

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