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New polyphenols active on beta-amyloid aggregation.

Abstract：

:New polyphenol classes have been tested against amyloid-beta peptide aggregation. We have identified four novel polyphenols which could be efficient fibril inhibitors in Alzheimer's disease: malvidin and its glucoside and curculigosides B and D. We suggest that molecules with the particular C(6)-linkers-C(6) structure could be potent inhibitors. From the results reported for the flavan-3-ol family, their anti-amyloidogenic effects against whole peptides (1-40 and 1-42) could involve several binding sites.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Rivière C,Richard T,Vitrac X,Mérillon JM,Valls J,Monti JP

doi

10.1016/j.bmcl.2007.11.028

subject

Has Abstract

pub_date

2008-01-15 00:00:00

pages

828-31

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01337-6

journal_volume

18

pub_type

杂志文章

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