Abstract:
:The synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated to discover SAR at P(1') and P(3') positions, and most of these derivatives exhibit better in vitro antibacterial activity than existing drugs against drug-resistant clinical isolates including MRSA, PRSP, and Haemophilus influenzae.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Shi W,Ma H,Duan Y,Aubart K,Fang Y,Zonis R,Yang L,Hu Wdoi
10.1016/j.bmcl.2010.11.102subject
Has Abstractpub_date
2011-02-01 00:00:00pages
1060-3issue
3eissn
0960-894Xissn
1464-3405pii
S0960-894X(10)01727-0journal_volume
21pub_type
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