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Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors.

Abstract：

:The synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated to discover SAR at P(1') and P(3') positions, and most of these derivatives exhibit better in vitro antibacterial activity than existing drugs against drug-resistant clinical isolates including MRSA, PRSP, and Haemophilus influenzae.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shi W,Ma H,Duan Y,Aubart K,Fang Y,Zonis R,Yang L,Hu W

doi

10.1016/j.bmcl.2010.11.102

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

1060-3

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01727-0

journal_volume

21

pub_type

杂志文章

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