The specificity of neuropsychological impairment in predicting antidepressant non-response in the very old depressed.

abstract：OBJECTIVES:Recent data suggests that statins have positive effects on cognition in older adults. Studies in patients with mood disorders have found contradicting positive and negative effects of statins on mood and cognition, with limited data in bipolar disorder (BD). The objective of this study was to assess the asso...

journal_title：International journal of geriatric psychiatry

authors： Rej S,Schulte SW,Rajji TK,Gildengers AG,Miranda D,Menon M,Butters MA,Mulsant BH

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydro...

journal_title：International journal of geriatric psychiatry

authors： Shin S,Stewart R,Ferri CP,Kim JM,Shin IS,Kim SW,Yang SJ,Yoon JS

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Sleep problems and depression are common symptoms in dementia with Lewy bodies (DLB), where patients typically experience subjectively poor sleep quality, fatigue and excessive daytime sleepiness. However, whilst sleep disturbances have been linked to depression, this relationship has not received much attent...

journal_title：International journal of geriatric psychiatry

authors： Elder GJ,Colloby SJ,Lett DJ,O'Brien JT,Anderson KN,Burn DJ,McKeith IG,Taylor JP

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The relationships between apathy, depression and functional impairment in questionable dementia (QD) and Alzheimer's disease (AD) are complex. This study aimed to explore the interactions between severity of apathy, depression and functional performance; and to investigate the effects of apathy alone, depres...

journal_title：International journal of geriatric psychiatry

authors： Lam LC,Tam CW,Chiu HF,Lui VW

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between care management arrangements and the Care Programme Approach (CPA) in the context of old age mental health services and, particularly, dementia services. METHOD:The information reported is from a national study of care management arrangements, funded by the Department of H...

journal_title：International journal of geriatric psychiatry

authors： Hughes J,Stewart K,Challis D,Darton R,Weiner K

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:Patient expectations of treatment effects could influence neuropsychological and clinical outcomes in clinical trials of behavioral and lifestyle interventions, which could potentially confound the interpretation of findings. Our aim was to examine whether patient expectancy mediated effectiveness of Mindful...

journal_title：International journal of geriatric psychiatry

authors： Haddad R,Lenze EJ,Nicol G,Miller JP,Yingling M,Wetherell JL

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Many studies have assessed the impact of caregivers' work activities on the caregiver. There is growing concern about the ever-increasing problems, both physical and physiological, faced by health care workers who provide care for the ill and incapacitated. AIM:The aim of the study was to examine what, if a...

journal_title：International journal of geriatric psychiatry

authors： Chiou CJ,Chen IP,Wang HH

更新日期：2005-09-01 00:00:00

abstract：:Alzheimer's disease (AD) affects millions of people worldwide and the number of AD cases will increase with increased life expectancy. Today there is no cure for this devastating and always lethal disease and therefore it is of great interest for patients, relatives and societies to find new drugs that can hinder the ...

journal_title：International journal of geriatric psychiatry

authors： Ankarcrona M,Winblad B

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Systematic evidence became available in the late 1990s on efficacy of cholinesterase inhibitors (CHEIs) for patients with mild to moderate Alzheimer's disease (AD) and they began to be used sporadically. Since January 2001 UK based guidelines indicated that one of three cholinesterase inhibitors (CHEIs) coul...

journal_title：International journal of geriatric psychiatry

authors： Matthews FE,McKeith I,Bond J,Brayne C,MRC CFAS.

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to identify whether the onset and the end of fear of falling (FOF) are associated with psychosocial consequences (in terms of depressive symptoms, loneliness, social isolation, autonomy, and subjective well-being). METHODS/DESIGN:Longitudinal data for this study were taken from...

journal_title：International journal of geriatric psychiatry

authors： Hajek A,König HH

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:There are few studies evaluating treatment in gerontopsychiatric day-clinics. In this paper, data are presented on the outcome of day-clinic treatment in late-life depression. METHOD:Forty-four depressed elderly patients (mean Hamilton Depression Score: 17.6) were examined at admission and discharge for psy...

journal_title：International journal of geriatric psychiatry

authors： Bramesfeld A,Adler G,Brassen S,Schnitzler M

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To find a blood biomarker and disease-related peptides in Alzheimer's disease (AD), we comprehensively detected serum peptides. METHODS:Ion intensity of serum peptides from 62 AD patients and 82 control subjects was measured by mass spectrometry. RESULTS:A total of 157 peptides were detected from 30 AD pati...

journal_title：International journal of geriatric psychiatry

authors： Noguchi M,Sato T,Nagai K,Utagawa I,Suzuki I,Arito M,Iizuka N,Suematsu N,Okamoto K,Kato T,Yamaguchi N,Kurokawa MS

更新日期：2014-08-01 00:00:00

abstract：AIM:To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline. METHODS:Thirty-two SNCI subjects, 16 with mild cognitive impairment (MCI) and 27 control subjects had clinical assessment and magnetic...

journal_title：International journal of geriatric psychiatry

authors： Archer HA,Kennedy J,Barnes J,Pepple T,Boyes R,Randlesome K,Clegg S,Leung KK,Ourselin S,Frost C,Rossor MN,Fox NC

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Evidence from previous studies suggests that alterations in lipid levels may be associated with depression in old age. The objective of this study was to investigate the association between serum lipids and depressive symptoms in a population of elderly men. SUBJECTS AND METHODS:Altogether 470 men born betwe...

journal_title：International journal of geriatric psychiatry

authors： Aijänseppä S,Kivinen P,Helkala EL,Kivelä SL,Tuomilehto J,Nissinen A

更新日期：2002-07-01 00:00:00

abstract：RATIONALE:Quetiapine was approved in Germany as an atypical antipsychotic for treatment of schizophrenia in 2000, followed by the approval as an antipsychotic for treatment of bipolar mania in 2003. The approval of quetiapine for treatment of bipolar depression is expected. We hypothesized that the psychogeriatric pres...

journal_title：International journal of geriatric psychiatry

authors： Hilwerling L,Juckel G,Schröder SG

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:While activities of daily living are by definition preserved in mild cognitive impairment (MCI), there is evidence of poorer instrumental activities of daily living (IADL) functioning in MCI compared to normal ageing. The aims of the present study were to examine differences in IADL between individuals with M...

journal_title：International journal of geriatric psychiatry

authors： Reppermund S,Sachdev PS,Crawford J,Kochan NA,Slavin MJ,Kang K,Trollor JN,Draper B,Brodaty H

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:The post-hoc analyses reported here evaluate the specific effects of memantine treatment on ADAS-cog single-items or SIB subscales for patients with moderate to severe AD. METHODS:Data from six multicentre, randomised, placebo-controlled, parallel-group, double-blind, 6-month studies were used as the basis ...

journal_title：International journal of geriatric psychiatry

authors： Mecocci P,Bladström A,Stender K

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:This study examined the moderating effect of caregiver burden on the relationship between the health status of Alzheimer's disease (AD) patients and their use of institutional services (i.e., hospitalization, nursing home, and residential care). METHODS:Data were obtained at baseline and at 3, 6, and 9 month...

journal_title：International journal of geriatric psychiatry

authors： Miller EA,Rosenheck RA,Schneider LS

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:In recent years, there has been a blossoming of studies examining cerebrospinal fluid (CSF) as a method of studying the pathophysiology of delirium. We systematically reviewed the literature for CSF studies in delirium and provide here a summary of the implications for our understanding of delirium pathophysi...

journal_title：International journal of geriatric psychiatry

authors： Hall RJ,Watne LO,Cunningham E,Zetterberg H,Shenkin SD,Wyller TB,MacLullich AMJ

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the degree to which longitudinal stability of subsyndromal symptoms of depression (SSD) is associated with conversion to dementia in patients with mild cognitive impairment (MCI). METHODS:Data from 405 MCI participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were analyze...

journal_title：International journal of geriatric psychiatry

authors： Mackin RS,Insel P,Aisen PS,Geda YE,Weiner MW,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVES:The present study assessed whether caregiving contextual factors moderated outcomes of a caregiver intervention. METHODS:Extant data from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) II study, a randomized-control trial of a multi-component, multi-site intervention for dementia caregiver...

journal_title：International journal of geriatric psychiatry

authors： Hatch DJ,DeHart WB,Norton MC

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:There is much variation in the services provided for older people with mental health problems. In England, the National Service Framework for Older People (NSFOP) sought to address these inconsistencies and improve care. This study describes the situation three years after its publication. METHODS:A postal ...

journal_title：International journal of geriatric psychiatry

authors： Tucker S,Baldwin R,Hughes J,Benbow S,Barker A,Burns A,Challis D

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To compare the scores on the Relative Stress Scale (RSS) with those on the General Health Questionnaire (GHQ) and the Geriatric Depression Scale (GDS), and to establish a cut-off score for RSS in order to distinguish carers with symptoms of psychiatric disorders from those without. METHODS:One hundred and ni...

journal_title：International journal of geriatric psychiatry

authors： Ulstein I,Wyller TB,Engedal K

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:To summarise existing knowledge of outcomes of older hospital patients with cognitive impairment, including the type and frequency of outcomes reported, and the additional risk experienced by this patient group. METHODS:Integrative literature review. Health care literature databases, reports, and policy doc...

journal_title：International journal of geriatric psychiatry

authors： Fogg C,Griffiths P,Meredith P,Bridges J

更新日期：2018-06-26 00:00:00

abstract：OBJECTIVE:Meta-analyses of antidepressant drug treatment trials have found that increasing age is associated with a less favourable outcome. Because the prevalence of geriatric characteristics, like disability, medical co-morbidity, malnutrition, cognitive (dys)function and frailty increase with age and are associated ...

journal_title：International journal of geriatric psychiatry

authors： Benraad CE,Kamerman-Celie F,van Munster BC,Oude Voshaar RC,Spijker J,Olde Rikkert MG

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Mild Cognitive Impairment (MCI) is a borderline state between age-associated cognitive decline and mild dementia. MCI is separated from mild dementia by an absence of global intellectual deterioration and the preservation of activities of daily living (ADL). However, even mild degrees of cognitive deteriorat...

journal_title：International journal of geriatric psychiatry

authors： Perneczky R,Pohl C,Sorg C,Hartmann J,Tosic N,Grimmer T,Heitele S,Kurz A

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Depression frequently co-occurs with cognitive decline, but the nature of this association is unclear. We examined relations of late-life depressive symptom patterns to subsequent domain-specific cognitive changes. METHODS:Depressive symptoms were measured at up to 3 timepoints among 11,675 Nurses' Health S...

journal_title：International journal of geriatric psychiatry

authors： Gillis JC,Chang SC,Devore EE,Rosner BA,Grodstein F,Okereke OI

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:There is little information on the efficacy and side effects of antidepressant treatment in elderly patients with combined depression and cognitive impairment without dementia (DEP-MCI), and it is unclear if cognitive performance improves with antidepressant response in these patients. METHODS:In 39 elderly...

journal_title：International journal of geriatric psychiatry

authors： Devanand DP,Pelton GH,Marston K,Camacho Y,Roose SP,Stern Y,Sackeim HA

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to examine whether the reversal of compromised regional cerebral blood flow (rCBF) in older patients with major depressive disorder (MDD) is dependent on specific parameters of selective serotonin reuptake inhibitor (SSRI) treatment and to examine the efficacy of such treatment. ...

journal_title：International journal of geriatric psychiatry

authors： Hanada H,Imanaga J,Yoshiiwa A,Yoshikawa T,Tanaka Y,Tsuru J,Inoue A,Ishitobi Y,Okamoto S,Kanehisa M,Maruyama Y,Ninomiya T,Higuma H,Isogawa K,Kawasaki T,Fujioka T,Akiyoshi J

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To investigate patient predictors of response to treatment of Major Depressive Episode (MDE) in Alzheimer's disease (AD). METHODS:Forty-four outpatients with AD and MDE were randomized to receive either sertraline or placebo in a 12-week placebo-controlled, flexible-dose clinical trial after a one week singl...

journal_title：International journal of geriatric psychiatry

authors： Steinberg M,Munro CA,Samus Q,V Rabins P,Brandt J,Lyketsos CG

更新日期：2004-02-01 00:00:00