Abstract：
BACKGROUND:The relationships between apathy, depression and functional impairment in questionable dementia (QD) and Alzheimer's disease (AD) are complex. This study aimed to explore the interactions between severity of apathy, depression and functional performance; and to investigate the effects of apathy alone, depression alone and coexistence of apathy and depression on the functional performance in subjects with QD and AD. METHODS:One hundred ninety-five subjects with QD and 96 subjects with mild AD were recruited. Apathy and depression were rated using the Neuropsychiatric Inventory and functional disability was measured using the Disability Assessment for Dementia (DAD). RESULTS:Severity of apathy and depression symptoms were associated with poorer functional performance in QD and apathy was associated with poorer functional performance in AD. In QD, subjects with apathy, depression, or coexistence of apathy and depression had poorer functional performance than those with neither apathy nor depression. The coexistence of apathy and depression did not produce more severe functional disability than apathy alone or depression alone. In AD, subjects with apathy had poorer functional performance than those without apathy. Depression in the absence of apathy was not associated with more severe functional disability. CONCLUSION:Apathy and depression symptoms are common in the early course of AD. Apathy and depression had different effects on functional performances in the subjects with QD from those with AD.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Lam LC,Tam CW,Chiu HF,Lui VWdoi
10.1002/gps.1694subject
Has Abstractpub_date
2007-05-01 00:00:00pages
431-7issue
5eissn
0885-6230issn
1099-1166journal_volume
22pub_type
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2008-10-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,meta分析
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更新日期：2003-12-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
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更新日期：2000-10-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.2485
更新日期：2011-01-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2018-06-27 00:00:00
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2019-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.4975
更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.642
更新日期：2002-06-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章
doi：10.1002/gps.388
更新日期：2001-06-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1092
更新日期：2004-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2012-08-01 00:00:00
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更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-05-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
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更新日期：2005-07-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
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更新日期：2010-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.649
更新日期：2003-01-01 00:00:00
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更新日期：2010-03-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2018-04-01 00:00:00
