Abstract:
OBJECTIVES:To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD:The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and 'A short cognitive performance test for assessing memory and attention' (SKT) during vitamin substitution. RESULTS:Patients with mild-moderate dementia and elevated plasma homocysteine levels improved clinically with increased test scores after vitamin substitution, while severely demented patients and patients with normal plasma homocysteine levels did not improve clinically. CONCLUSIONS:Plasma homocysteine may be the best marker for detecting treatable cobalamin/folate deficiency in patients with dementia.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Nilsson K,Gustafson L,Hultberg Bdoi
10.1002/gps.388subject
Has Abstractpub_date
2001-06-01 00:00:00pages
609-14issue
6eissn
0885-6230issn
1099-1166journal_volume
16pub_type
临床试验,杂志文章abstract:OBJECTIVE:To evaluate the cost-consequences of an intervention for the management of neuropsychiatric symptoms in nursing home residents with young-onset dementia. METHODS:A stepped wedge design was used. The intervention consisted of an educational program and a multidisciplinary care program and was implemented in 1...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.5229
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The objective of the study is to assess combined antidepressant and memantine treatment in older patients presenting with depression and cognitive impairment. METHODS:Thirty-five depressed patients with cognitive impairment participated in this open-label pilot study. We evaluated whether, over a 48-week per...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4375
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Cross-sectional studies indicate that, in comparison to younger patients, older schizophrenic patients have a higher risk for neuroleptic-induced Parkinsonism and tardive dyskinesia (TD). It has been suggested, therefore, that older patients with schizophrenia could be maintained on reduced doses of conventi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.740
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:The objectives of this study are to explore the feasibility of a multicomponent intervention programme and to evaluate its impacts on behavioural and psychological symptoms of dementia (BPSD) and psychological health of caregivers. METHODS:Fifty-six community-dwelling people with dementia (PWD) and knee ost...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5191
更新日期:2019-12-01 00:00:00
abstract::The purpose of this article is to provide data for advanced interpretation of MMSE performance in community-dwelling elderly persons and in geriatric neuropsychiatry inpatients. Age- and education-corrected cutoff scores, standard errors of measurement and standard errors of difference were computed using previously p...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(1998100)13:10<661::aid-gps
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Despite being simple and cheap, the EEG is not often used in clinical practice. METHODOLOGY:Literature search using PUBMED and Medline. RESULTS:Quantitative EEG can help to identify mild dementia and mild cognitive impairment and can increase diagnostic accuracy when used with other imaging techniques. EEG...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.1393
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:Mild cognitive impairment in Parkinson's disease (PD-MCI) has been suggested to be a predictor for the development of PD dementia (PDD). This study explored the incidence and possible neuropsychological domain differences between PD patients with PD-MCI and without cognitive impairment (normal cognitive funct...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4261
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:To gain more insight into the association between severity of Alzheimer's Disease (AD) and prevalence of comborbid depression. METHODS:A systematic literature review based on the Cochrane methodology was performed. PubMed, PsychINFO and EMBASE databases were searched for existing studies that fulfilled pred...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.1809
更新日期:2007-11-01 00:00:00
abstract::Dementia in community settings is often diagnosed by computerized algorithms. This study examines the extent to which independent diagnosticians agreed among themselves in diagnosing dementia, severity and type when presented with data obtained during a population-based incidence study of cognitive decline and dementi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(1998120)13:12<852::aid-gps
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:To assess the association between early parental death and the risk of dementia in adult life and to examine the risk factors associated with early parental death in people with and without dementia. METHODS/DESIGN:A population-based case-control study of a sample of 65 997 participants from the Survey of H...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5328
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:To investigate the efficacy of the chronic usage of the cholinesterase inhibitor rivastigmine in patients with dementia in the prevention of delirium in case of hospitalisation. DESIGN:Retrospective cohort study. SETTING:Non-geriatric wards of an 1120 bed general teaching hospital in s-Hertogenbosch, The N...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1138
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:Psychosis, like other neuropsychiatric symptoms of dementia, has many features that make predictive modeling of its onset difficult. For example, psychosis onset is associated with both the absolute degree of cognitive impairment and the rate of cognitive decline. Moreover, psychotic symptoms, while more like...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4326
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Timely recognition and diagnosis of dementia is the pre-condition for improving dementia care, but diagnosis often occurs late in the disease process. OBJECTIVE:To compare facilitators and obstacles to the timely recognition of dementia across eight European Union states, in order to implement established p...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.1302
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:Suicide in older adults is a major public health issue. Past research across the US adult population has linked prescription medication misuse with suicidal ideation. No work has evaluated associations between prescription opioid or benzodiazepine misuse and suicidal ideation in older adults, and this work a...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4999
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:We hypothesized that alterations of subcomponents ('harm-avoidance') of personality and the sense of Self in patients with PD would be associated with executive cognitive dysfunction. METHODS:Thirty-four patients with PD and 17 age-matched controls with chronic disease were assessed with a set of neuropsycholo...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1845
更新日期:2008-01-01 00:00:00
abstract::As an elder's functional impairment increases, so in general does the tendency for the caregiver to intervene in the elder's daily activities and initiatives. To a certain extent, such intervention is necessary to compensate for the elder's loss of independent ability, and without such intervention, adverse outcomes f...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199709)12:9<920::aid-gps66
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:The authors examine changes in psychiatric referral patterns for geriatric inpatients since last reported in the United States, more than 20 years ago, and compare geriatric psychiatric referrals to those of a non-geriatric cohort. METHOD:Retrospective study comparing psychiatric diagnosis, treatment and aft...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2221
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:This study examined the associations of personality characteristics with both subtypes and symptom dimensions of depression in older adults. METHODS:Three hundred and seventy-eight depressed older adults participated in the Netherlands Study of Depression in Older Persons. Personality characteristics were as...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4670
更新日期:2017-12-01 00:00:00
abstract:OBJECTS:Identification of biomarkers for Alzheimer's disease (AD) is important for its early diagnosis and prevention and a key in advancing our understanding of its pathophysiology. The aim of this study was to determine whether systemic inflammatory interleukin-1ß (IL-1ß) and interleukin-6 (IL-6) as well as hypertens...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.3816
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:Staff ratings of quality of life (QOL) in dementia are often lower and more strongly related to the cognitive functioning of the person with dementia than self-ratings. However, cognition-related items in QOL measures and limited cognitive screening measures hamper a clear understanding of the relationship, 2...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4895
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Cross validation study of the MoCA for the detection of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) in a community-based cohort residing in the Southeastern United States. METHODS:One hundred and eighteen English-speaking older adults, who underwent diagnostic evaluation as part of an on-goi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2101
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:Currently available pharmacological treatments in Alzheimer's disease (AD) have been associated with modest benefits to cognition, but the impact on health-related quality of life (HRQoL) is less well established. Our aim was to determine if decline of specific cognitive functions commonly associated with AD ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4050
更新日期:2014-07-01 00:00:00
abstract::Reduced N-acetyl aspartate (NAA) and increased myo-inositol (MI) levels have been reported in patients with dementia of Alzheimer type (DAT) in comparison with controls. We wished to assess the validity of these findings and to evaluate possible correlations of metabolite proportions with cognitive dysfunction in DAT....
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199703)12:3<349::aid-gps50
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:There are few studies evaluating treatment in gerontopsychiatric day-clinics. In this paper, data are presented on the outcome of day-clinic treatment in late-life depression. METHOD:Forty-four depressed elderly patients (mean Hamilton Depression Score: 17.6) were examined at admission and discharge for psy...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/1099-1166(200101)16:1<82::aid-gps281>3.0.c
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The mini-mental state exam (MMSE) has been used to address questions such as determination of appropriate cutoff scores for differentiation of individuals with intact cognitive function from patients with dementia and rate of cognitive decline. However, little is known about the relationship of performance i...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2282
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Neuropsychiatric symptoms (NPs) affect almost all patients with Alzheimer disease (AD). Because of the complications associated with the pharmacological treatment, nonpharmacological treatment (such as physical activity) can be considered as an additional complementary treatment option for NPs. The aim of thi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.4962
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:This paper investigates the potential effects of a policy change in the funding of UK residential care. The White Paper Modernising Social Services (Cm 4169, 1998) outlined plans to change the distribution of the Residential Allowance (RA), payable in support of residents in independent residential or nursin...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.814
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:We hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre-dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro-inflammation. We aimed to determine whether peripheral lymphocytes are related to the ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4660
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to examine the frequency of delusions and hallucinations in patients with Alzheimer's disease (AD) and to investigate factors associated with each or the combination of the two. DESIGN:This was a cross-sectional, case-control study. SETTING:Neuropsychiatry and Memory Group, Th...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(200002)15:2<99::aid-gps82>
更新日期:2000-02-01 00:00:00
abstract::In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Books, ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00