Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine.

Abstract:

OBJECTIVES:To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD:The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and 'A short cognitive performance test for assessing memory and attention' (SKT) during vitamin substitution. RESULTS:Patients with mild-moderate dementia and elevated plasma homocysteine levels improved clinically with increased test scores after vitamin substitution, while severely demented patients and patients with normal plasma homocysteine levels did not improve clinically. CONCLUSIONS:Plasma homocysteine may be the best marker for detecting treatable cobalamin/folate deficiency in patients with dementia.

authors

Nilsson K,Gustafson L,Hultberg B

doi

10.1002/gps.388

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

609-14

issue

6

eissn

0885-6230

issn

1099-1166

journal_volume

16

pub_type

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