Abstract：
OBJECTIVE:To investigate patient predictors of response to treatment of Major Depressive Episode (MDE) in Alzheimer's disease (AD). METHODS:Forty-four outpatients with AD and MDE were randomized to receive either sertraline or placebo in a 12-week placebo-controlled, flexible-dose clinical trial after a one week single-blind placebo phase. All participants were evaluated for depression at entry using the 21-item Hamilton Depression Rating Scale (HDRS) and the Cornell Scale for Depression in Dementia (CSDD). All subjects completed baseline neuropsychological testing. Caregiver burden and depression were also measured. The forty-two subjects who completed at least one post-enrollment follow-up visit were included in the analysis. RESULTS:No baseline demographic, mood, neuropsychiatric, neuropsychological, or caregiver variable was a statistically significant predictor of response to treatment. There were trends for African-American patients (p=0.07) and those with milder baseline agitation/aggression (p=0.08) to respond better. CONCLUSION:No baseline characteristic assessed clearly predicts response to treatment of MDE in AD. A diverse population of depressed AD patients may thus respond similarly to the same treatment.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Steinberg M,Munro CA,Samus Q,V Rabins P,Brandt J,Lyketsos CGdoi
10.1002/gps.1048subject
Has Abstractpub_date
2004-02-01 00:00:00pages
144-50issue
2eissn
0885-6230issn
1099-1166journal_volume
19pub_type
临床试验,杂志文章,随机对照试验abstract：OBJECTIVE:Among dementia professionals in several European countries, it is believed that dementia is under-diagnosed and under-treated to a greater extent among ethnic minorities than in the native population. It is unknown whether this belief holds true. The objective of this study was to compare the prevalence of re...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2650
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:To examine the effects of risperidone and olanzapine on cognitive functioning in elderly patients with schizophrenia or schizoaffective disorder. METHOD:One hundred seventy-six elderly inpatients and outpatients with schizophrenia or schizoaffective disorder were enrolled in this multicenter, double-blind tr...
journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1002/gps.929
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVES:The cognitive subscale of the Alzheimer's Disease Assesment Scale (ADAS-Cog) is the most widely used test in clinical trials dealing with Alzheimer's disease (AD). The aim of this study was to investigate the validity and reliability of the Turkish version of ADAS-Cog. METHODS:Twenty-nine patients with AD, ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1457
更新日期：2006-03-01 00:00:00
abstract：:This cross-sectional study explored age-related differences in the frequency of diagnosis of personality disorder (PD) among 790 veterans admitted to a psychiatric inpatient unit across three age groups: 20-39, 40-59, and 60+. Older adults obtained a lower frequency (55.4%) of PD diagnosis than middle-aged adults (69....
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/1099-1166(200009)15:9<831::aid-gps208>3.0.
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:To analyse the relationship between mental disorders and mortality rates in the elderly community of Zaragoza, Spain. METHODS:Baseline, cross-sectional study (two-stage screening) of a representative, stratified sample (N=1080) of the elderly (65+ years) living in the community. Follow-up study (4.5 years). ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199912)14:12<1031::aid-gps
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVE:to investigate the relationship between pre-morbid personality and behavioural and psychological symptoms of dementia (BPSD). METHODS:we studied 58 subjects with dementia and depression and/or psychosis residing in 11 Sydney nursing homes cross-sectionally. Informal caregivers completed ratings of residents'...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.697
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVE:This study examined the attribution of mild cognitive impairment (MCI) etiology assigned by individuals with MCI and their care partners, and the extent to which the dyads agreed on the attribution of MCI etiology. METHODS:We conducted secondary analyses of cross-sectional data from a cohort of individuals w...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4028
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of the DementiAbility Methods: The Montessori Way (DMMW) on agitation in long-term care home residents with dementia. The activities using the DMMW are hypothesized to reduce agitation in terms of its frequency and disruptiveness to greater extent than structured social activities as...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5063
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:The pattern of neural damage in dementia with Lewy Bodies (DLB) led us to hypothesize that patients with DLB would be particularly impaired on parallel ('pop-out') search tasks, relative to serial search tasks, and that this would serve to distinguish DLB from other forms of neurodegenerative disease, partic...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1159
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:The aim of the study is to investigate the performance of the clock drawing test as a screening tool for cognitive impairment in Huntington's disease (HD) mutation carriers. METHODS:The performance of the clock drawing test was assessed in 65 mutation carriers using the Shulman and the Freund scoring system...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4412
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to compare the impact of nortriptyline to sertraline on change in cognitive functioning in depressed older adults. METHODS:We used pre-post neuropsychological data collected as part of a 12-week medication trial comparing sertraline to nortriptyline in the treatment of older adults ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.2783
更新日期：2012-08-01 00:00:00
abstract：AIM:To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline. METHODS:Thirty-two SNCI subjects, 16 with mild cognitive impairment (MCI) and 27 control subjects had clinical assessment and magnetic...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2440
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVES:A screening strategy composed of three-item temporal orientation and three-word recall has been increasingly used for detecting cognitive impairment. However, the intervening task administered between presentation and recall has varied. We evaluated six brief tasks that could be useful as intervening distrac...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4282
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) share clinical features like cognitive decline, motor disturbances en psychiatric symptoms. Overlapping symptoms may cause physicians to mistake DLB for CJD. METHODS:Clinical data of 12 patients with autopsy-confirmed DLB who had been clini...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1602
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVE:In an earlier report, response inhibition predict antidepressant non-response in late-life depression (Sneed et al., 2007). The purpose of this study was to ascertain whether this effect is specific to response inhibition or whether impairment in other cognitive domains also predicts non-response. METHOD:Old...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1002/gps.1889
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:This study explored whether patients with late-onset major depressive disorder showed higher carotid artery intima-medium thickness (IMT) and investigated the relationship between the IMT and white matter hyperintensities on magnetic resonance imaging (MRI) among patients. METHODS:Fourteen elderly patients ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1420
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:Impaired insight into illness is a prevalent feature of schizophrenia, which negatively influences treatment adherence and clinical outcomes. Little is known about the effects of aging on insight impairment. We aimed to review the available research literature on the effects of aging on insight into illness ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.4154
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:The Lewy body dementias (LBD, dementia with Lewy bodies and Parkinson's disease dementia) are the second most common cause of neurodegenerative dementia but remain under-recognised, with long delays from initial assessment to diagnosis. Whilst validated instruments have been developed for key symptoms, there ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4609
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:We investigated cognitive dysfunction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) who present hemispheric asymmetries of cerebral metabolic rate of glucose (CMRglc) decrease on (18) F-fluorodeoxyglucose positron emission tomography. METHODS:Based on the hemispheric...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4287
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:Apathy is one of the most frequent symptoms of dementia, whose underlying neurobiology is not well understood. The objective was to analyze the correlations of apathy and its dimensions with gray and white matter damage in the brain of patients with advanced Alzheimer's disease (AD). METHODS:The setting of t...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4548
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:To compare the frequency and clinical correlates of neuropsychiatric symptoms in patients with Parkinson's disease (PD) with and without dementia and in those with dementia with Lewy bodies (DLB). METHODS:Neuropsychiatric symptoms during the month prior to assessment were assessed in clinically diagnosed PD...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.389
更新日期：2001-05-01 00:00:00
abstract：:The views of GPs about psychiatric services for dementia were obtained by questionnaire survey. Provision of adequate long term care, together with support for both family carers and healthcare workers were strongly stated needs. Other needs were rapid access to care, clear diagnosis, special needs of young patients w...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/1099-1166(200008)15:8<758::aid-gps295>3.0.
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVES:The purpose of this study is to identify risk factors for nursing home placement of cognitively-impaired elderly, with special attention to the role of psychosocial factors such as the caregiver's preference for institutionalization and the quality of the dyadic relationship. METHODS:Partners, children and ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.484
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Vascular dementia (VaD) is associated with impairments in cognitive, motor, and functional domains. Patients with VaD display diverse cognitive and motor deficits, however, and relationships between these impairments and independent living abilities remain unclear. OBJECTIVES:The purpose of the present stud...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.539
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Cerebromicrovascular disease (CMVD) strikes 87% of the population older than 65 years and is linked to an increased risk of ischemic stroke, depression, cognitive impairment, and Alzheimer's disease. Despite the wealth of knowledge on the consequences to the body stemming from poor vascular health, little fo...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.4046
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:This study aimed to: (i) replicate previous findings that women experience more strain and distress than men when caring for dementing spouses; (ii) explore what factors underlie this sex difference. DESIGN:Two closely matched subsamples of spouse carers, husbands and wives respectively, were selected and th...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:This study aims to determine the long-term effect of a stepped care cognitive behavioral therapy prevention program for depression in older people and the factors predicting or moderating outcome. METHODS:In a randomized controlled trial, 136 participants, aged 55 years or older, who had been treated for dep...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.4010
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:Several potentially modifiable risk factors for cognitive decline and dementia have been identified, including low educational attainment, smoking, diabetes, physical inactivity, hypertension, midlife obesity, depression, and perceived social isolation. Managing these risk factors in late midlife and older ag...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4790
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:Fear of falling (FoF) is common and associated with poorer functional outcomes after hip fracture. We sought to differentiate patterns of FoF at 4 and 12 weeks after surgical repair for hip fracture and examine predictors of FoF. METHODS/DESIGN:Secondary analysis of existing data from a 52-week prospective ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5261
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To determine the national prevalence of psychotropic use and association with neuropsychiatric symptoms among patients with dementia. METHODS:Participants diagnosed with dementia (n = 414) in the Aging, Demographics, and Memory Study, a nationally representative survey of US adults >70 years old. Diagnosis w...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4452
更新日期：2017-02-01 00:00:00
