Abstract:
OBJECTIVE:The Lewy body dementias (LBD, dementia with Lewy bodies and Parkinson's disease dementia) are the second most common cause of neurodegenerative dementia but remain under-recognised, with long delays from initial assessment to diagnosis. Whilst validated instruments have been developed for key symptoms, there is no brief instrument for overall diagnostic assessment suitable for routine practice. We here report the development of such assessment toolkits. METHODS:We developed the LBD assessment toolkits in three stages. First, we conducted a systematic search for brief validated assessments for key symptoms and combined these into draft instruments. Second, we obtained feedback on acceptability and feasibility through two rounds of interviews with our patient and public involvement group. This led to modification of the toolkits. Finally, we piloted the toolkits in a feasibility study in routine dementia and Parkinson's disease services to produce final instruments suitable for routine clinical practice. RESULTS:Eleven clinicians, working in both dementia/memory assessment and Parkinson's disease/movement disorder services, consented to pilot the assessment toolkits and provide feedback on their feasibility. Clinicians worked in routine health service (not academic) settings and piloted the draft toolkits by integrating them into their regular clinical assessments. Feedback obtained informally, by written comments and through qualitative interviews led to modifications and production of final acceptable versions. CONCLUSIONS:We were able to address an important need, the under-diagnosis of LBD, by developing toolkits for improving the recognition and diagnosis of the LBD, which were acceptable to clinicians working in routine dementia and Parkinson's disease services. © 2016 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Thomas AJ,Taylor JP,McKeith I,Bamford C,Burn D,Allan L,O'Brien Jdoi
10.1002/gps.4609subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1280-1304issue
12eissn
0885-6230issn
1099-1166journal_volume
32pub_type
杂志文章abstract:OBJECTIVE:Apathy is a prominent and disabling symptom in Parkinson's disease (PD) and is a multidimensional behaviour, but which dimensions are specifically affected is unclear. Therefore, the aim of this preliminary study was to determine the psychometric properties of the Dimensional Apathy Scale (DAS) and explore th...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4697
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Research has highlighted the influence of psychosocial factors on the wellbeing of carers of people with dementia. This study aimed to investigate the interrelationships between life events, depression and social support in carers of people with dementia. METHOD:Participants were 72 carers of people with de...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1136
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Psychiatric illness is common in older people in general hospitals, but little is known of the service models operating in the UK, or of the views of old age psychiatrists regarding service provision in this area. We set out to determine the range of UK old age psychiatry service models for older people in g...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.911
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are a common feature of Alzheimer's disease (AD), resulting in particular AD endophenotypes. The common AD genetic risk factor apolipoprotein E (APOE) has been suggested underlying these AD endophenotypes. METHODS:APOE genotyping, a comprehensive geriatric assessment (CGA), a...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2644
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To investigate a presumed correlation between clock drawing ratings and linear measurements of computerized tomography (CT) studies in demented patients. DESIGN:Blinded evaluations of clock drawing tests and CT studies of elderly dementia patients were conducted by a geriatric psychiatrist and a neuroradiol...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/1099-1166(200012)15:12<1130::aid-gps259>3.
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:An economic evaluation of dementia-related interventions from a societal perspective should take account of informal caregiving. We assessed informal caregiving time and report our findings on the validity and stability of our results. METHODS:Within the German IDA study ('Dementia Care Initiative in Primary...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2103
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Apathy is defined as an important loss of motivation in all domains of daily functioning. Especially in old age, apathy might be a specific neuropsychiatric syndrome separate from depression. There are indications that apathy in elderly subjects is related to vascular disease. OBJECTIVE:To assess the relati...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1872
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:Parental death during childhood, and offspring and spouse death during adulthood have individually been associated with faster cognitive decline and higher Alzheimer's disease (AD) risk in late life. However, the cumulative effect of childhood and adulthood family deaths on AD risk among different age cohort...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4319
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Depression is a frequent problem in stroke patients but, all too often, the problem goes unrecognized. How depression-like symptoms in post-stroke depression (PSD) should be interpreted is still subject to debate. If PSD has a distinct symptom profile of depression accompanying other chronic vascular somatic...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2236
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To compare the scores on the Relative Stress Scale (RSS) with those on the General Health Questionnaire (GHQ) and the Geriatric Depression Scale (GDS), and to establish a cut-off score for RSS in order to distinguish carers with symptoms of psychiatric disorders from those without. METHODS:One hundred and ni...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1660
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Among dementia professionals in several European countries, it is believed that dementia is under-diagnosed and under-treated to a greater extent among ethnic minorities than in the native population. It is unknown whether this belief holds true. The objective of this study was to compare the prevalence of re...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2650
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:Dementia is the most common neurological disease in older adults; headaches, including migraines, are the most common neurological disorder across all ages. The objective of this study was to explore the relationship between migraines and dementia, including Alzheimer's disease (AD) and vascular dementia (Va...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5180
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Little evidence is available about how quality of life (QoL) changes as dementia progresses. OBJECTIVES:We explored QoL trajectories over a 20-month period and examined what predicted change in QoL. METHOD:Fifty-one individuals with a diagnosis of Alzheimer's, vascular or mixed dementia (people with dement...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4044
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of persons suffering from Alzheimer's disease (AD). METHOD:Screening 5,092 elderly residents (90% of the population aged 65 and older) of Cache County, Utah, for dementia, we identified 198 persons wi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.448
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVES:Suicide in older adults is a major public health issue. Past research across the US adult population has linked prescription medication misuse with suicidal ideation. No work has evaluated associations between prescription opioid or benzodiazepine misuse and suicidal ideation in older adults, and this work a...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4999
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:T2 white matter hyperintensity (WMH) on magnetic resonance imaging (MRI) is associated with brain atrophy. Some previous studies examined the relation between the WMH and cortical atrophy, however, little is known about how the WMHs affect the pattern of cortical atrophy. Recent studies have revealed that pat...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2618
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Several studies have found that low grip strength is associated with dementia in Western populations. However, there have been few studies in Asian populations. This cross-sectional study aimed to examine whether grip strength is independently associated with dementia after controlling for other related fact...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2742
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Cross-sectional studies indicate that, in comparison to younger patients, older schizophrenic patients have a higher risk for neuroleptic-induced Parkinsonism and tardive dyskinesia (TD). It has been suggested, therefore, that older patients with schizophrenia could be maintained on reduced doses of conventi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.740
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is a common and disabling condition following a traumatic event. Despite its high prevalence rates, relatively little is known about the manifestation and course of the disorder in older adults. Moreover, there has been little evaluation of the efficacy of psychotherapeuti...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.2725
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:The number of older adults with severe mental health problems such as schizophrenia is likely to double in the next 20 years. The needs of this patient group change across the life course, but difficulties with social functioning persist into older age. Poorer social functioning is associated with poorer out...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5264
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:In this study, we explored association between hypertension and depression in the very elderly using a sample ranged in age from 90 to 108 years. METHODS:A cross-sectional study. RESULTS:The sample included 687 unrelated Chinese nonagenarians/centenarians (67.4% women, mean age 93.51 years). The mean depressi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2364
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:We investigated cognitive dysfunction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) who present hemispheric asymmetries of cerebral metabolic rate of glucose (CMRglc) decrease on (18) F-fluorodeoxyglucose positron emission tomography. METHODS:Based on the hemispheric...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4287
更新日期:2016-01-01 00:00:00
abstract::Divalproex is now commonly used to treat bipolar disorder in older patients. However, it has yet to be systematically studied in this population. This report describes six older bipolar patients treated with divalproex. Of the six, five showed some improvement with divalproex alone or in combination with other agents....
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199906)14:6<494::aid-gps96
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the short-term tolerability of two titration schedules of sublingual asenapine in older patients with psychosis, not associated with organic brain disease, and to compare asenapine pharmacokinetics in older patients versus younger adults with schizophrenia. METHODS:Patien...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/gps.2737
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To determine the rate of psychiatric symptoms among elderly people with learning disabilities who have dementia. DESIGN:Survey. SETTING:The general community of a county in the UK. PARTICIPANTS:The whole population of people with learning disabilities who were 65 years or over. The total population was 143...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To identify which specific depressive symptoms predict remission to aripiprazole augmentation in late-life treatment resistant depression. METHODS:This is a secondary analysis of data from a late-life treatment resistant depression trial examining the safety and efficacy of aripiprazole augmentation. Partici...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.4813
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:To compare directly, in the same patient cohort, the ease of use and tolerability of donepezil and galantamine in the treatment of Alzheimer's disease (AD), and investigate the effects of both treatments on cognition and activities of daily living (ADL). METHODS:Patients with mild to moderate AD from 14 Eur...
journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/gps.1038
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To gain insight into caregivers' understanding of the causes of behaviours they find problematic in people with Alzheimer's disease in order to inform the development of educational strategies. METHODS:A qualitative, semi-structured interview was used. Participants were 205 caregivers for a person with Alzhe...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1118
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:There is much variation in the services provided for older people with mental health problems. In England, the National Service Framework for Older People (NSFOP) sought to address these inconsistencies and improve care. This study describes the situation three years after its publication. METHODS:A postal ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1662
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Apathy-the most common behavioral disturbance in idiopathic normal pressure hydrocephalus (iNPH)-is associated with poor gait, but the role of apathy on gait improvement after cerebrospinal fluid (CSF) tapping has not been studied yet. This study aims to compare gait improvement after CSF tapping in iNPH pati...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4847
更新日期:2018-05-01 00:00:00