Abstract:
OBJECTIVE:T2 white matter hyperintensity (WMH) on magnetic resonance imaging (MRI) is associated with brain atrophy. Some previous studies examined the relation between the WMH and cortical atrophy, however, little is known about how the WMHs affect the pattern of cortical atrophy. Recent studies have revealed that patho-physiological role of WMH in affecting cortical atrophy may be different between hyperintensities in basal ganglia and thalami (B&T) and those in other regions. Based on a longitudinal study up to 5 years, we attempt to examine the temporal relation between the WMHs and cortical atrophy with special attention to the hyperintensities in the B&T. METHODS:We evaluated the temporal pattern of cortical atrophy in 74 cognitively normal subjects lacking hyperintensities in B&T (first analysis) and 13 cognitively normal subjects with hyperintensities in B&T (second analysis). The relationship between the baseline WMH severity and the cortical volume change during the observation period (mean: 3.8 years) was voxel basically evaluated on the images. RESULTS:The first analysis showed fairly axisymmetrical atrophy pattern in parietal, occipital, and precentral cortices, while the findings gained from the second appear to lack such systematic orderliness of the atrophy. CONCLUSION:This result shows that WMH may affect atrophy in multiple cerebral cortices even in cognitively normal subjects. Understanding the impact of WMH on the shrinkage shown in the brains of cognitively healthy older individuals is an important base for assessing the temporal pattern of atrophy of the individual with neurodegenerative disorder like AD.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Ota M,Nemoto K,Sato N,Mizukami K,Yamashita F,Asada Tdoi
10.1002/gps.2618subject
Has Abstractpub_date
2011-09-01 00:00:00pages
886-92issue
9eissn
0885-6230issn
1099-1166journal_volume
26pub_type
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